Glucocorticoid-induced osteopenia in adolescent heart transplant recipients

Osteoporosis in Adult Survivors of Adolescent Cardiac Transplantation May Be Related to Hyperparathyroidism, Mild Renal Insufficiency, and Increased Bone Turnover

“…In a study of 19 adolescents evaluated an average of 19 months after cardiac transplantation, BMD was 12% lower at the LS and 13% lower at the FN than published norms matched for sex and age. 13 Another study of 20 adults who had undergone renal transplantation during childhood found spinal osteoporosis in 30%, and LS BMD was inversely correlated with cumulative prednisone dose. 21 Although a high fracture prevalence has been reported in pediatric liver transplant recipients, 22 we did not observe an increased prevalence of fractures in this study.…”

“…13 Because the patients were not followed into adulthood, it was not clear whether these deficits in bone mass improved with time.…”

Therapeutic Drug Monitoring of Prednisolone After Lung Transplantation

“…[25][26][27][28] Although some studies have failed to demonstrate an association between cumulative steroid dose and development of osteoporosis 27,28 the majority of studies have clearly demonstrated cumulative steroid dose to be a predictor of decreased bone mineral density in renal, liver, heart, lung and bone marrow transplant recipients. 29 -36 Cumulative steroid dose is also associated with increased bone metabolism post-transplant 37,38 and risk of osteoporotic fracture.…”

Osteoporosis in chronically ill children

“…These show a high rate of osteopenia or apparent osteoporosis in a significant proportion of transplant recipients (38,39). BMD decreases significantly during the first 6 months after transplantation, despite normal graft function and growth (40).…”