“…The lipolysis, lipogenesis, and adipogenesis needed to create a Cushingoid distribution of white adipose tissue were hypothesized to contribute to this pattern of uptake Hwang, Catholic Kwandong University College of Medicine, Korea (2016) (Hwang et al 2016 ) | 1 (1) | 61-year-old woman with diffuse large B-cell lymphoma | Abnormal FDG biodistribution was hypothesized to be due to the prednisone given during R-CHOP treatment or herbal treatments that contain corticosteroids |
Kong, British Columbia Children's Hospital, Canada (2018) (Kong and Nadel 2018 ) | 1 (1) | 9-year-old girl with chronic Epstein-Barr virus infection | Chronic corticosteroid treatment was thought to be the cause of altered FDG biodistribution |
Caton, Brigham and Women's Hospital, USA (2018) (Caton et al 2018 ) | 1 (0) | 62-year-old man with HIV on HAART | Diffuse FDG localization to subcutaneous and visceral fat was found to be consistent with HIV-associated lipodystrophy |
Wong, C. S. Mott Children’s Hospital, USA (2020) (Wong et al 2020 ) | 13 (8) | Children and young adults (range: 7–23 years old), most of whom were diagnosed with leukemia or lymphoma except one patient diagnosed with Ewing sarcoma and another patient diagnosed with neuroblastoma | All identified patients with altered biodistribution received induction treatment which included corticosteroids. Areas of active disease were obscured by white fat activity, and repeat imaging one week later resulted in relatively normalized biodistribution sufficient to detect previously hidden lesions |
Staack, Mayo Clinic, Arizona, USA (2020) (Staack et al 2020 ) | 1 (1) | 59-year-old woman with lymphoma | In addition to chemotherapy, her treatment regimen also included dexamethasone to prevent cerebral edema. Therefore, altered FDG biodistribution was ascribed to glucocorticoid-induced Cushing syndrome |
Young, Yale New Haven Hospital, USA (2021) (Young et al 2021 ) | 1 (0) | 13-year-old boy with T-cell lymphoblastic lymphoma | Although the patient received high dose corticosteroids with induction chemotherapy, the authors hypothesized that L-asparaginase, which was administered only three hours prior to FDG-PET/CT, may have been responsible for diffuse white adipose uptake |
Kapoor, University of Kentucky Chandler Medical Center, USA (2021) (Kapoor et al 2... |
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