Glucocorticoid‐deficient hypoadrenocorticism secondary to intravascular lymphoma in the adrenal glands of a dog

Abstract

This is the first report of intravascular lymphoma causing glucocorticoid-deficient hypoadrenocorticism in a dog.

Suspected bilateral adrenal gland tumour causing primary Addison’s disease in a dog

“…In primary hypoadrenocorticism, destruction of the adrenal cortex is considered to be caused mostly by immune mediated adrenalitis [3][4][5] [6]. Rare mechanisms of hypoadrenocorticism include trauma, neoplasia (e. g. lymphoma [7], granulomatous inflammation, fungal disease, and iatrogenic causes) [8] [9]. One case report described bilateral primary adrenal gland neoplasia as the cause of primary hypoadrenocorticism in a dog, where histology revealed a highly anaplastic bilateral adrenal neoplasia [8].…”

“…One case report described bilateral primary adrenal gland neoplasia as the cause of primary hypoadrenocorticism in a dog, where histology revealed a highly anaplastic bilateral adrenal neoplasia [8]. Another 2 case reports referred to dogs with hypoadrenocorticism due to destruction of the adrenals by lymphoma [7] [9], which was also the reason for hypoadrenocorticism in a cat [10]. In humans, lymphoma is a reported cause of bilateral adrenal neoplasia causing hypoadrenocorticism [11] [12].…”

“…Anuric AKI caused by Addison's disease has not been described in dogs but has been documented sporadically in humans [25]. In addition, Addison's disease caused by bilateral adrenal tumours has only been very rarely described in dogs and cats [7][8] [10].…”

Primary hypoaldosteronism in a dog with pituitary and adrenal T‐cell lymphoma

“…Diagnosing the cause of a marked hyponatraemia and hyperkalaemia can be challenging if the clinical and laboratory findings are not characteristic of primary hypoadrenocorticism. The differential diagnosis should include neoplastic infiltration of the adrenal glands (Kook et al 2010, Buckley et al 2017. Involvement of both the pituitary and adrenal glands is very rare in veterinary medicine, and to our knowledge, has never been reported.…”

In this issue – March 2017

“…A report from the USA describes a case of non-specific weakness, anorexia and weight loss in a German Shepherd dog. 2 After extensive workup, the dog was diagnosed with glucocorticoiddeficient hypoadrenocorticism, based on ACTH stimulation testing. After progressive weakness and worsening of anaemia, approximately 1 month after presentation, the dog was euthanased.…”