Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.

Dighe, Rajan R.; Rojas, Fausto; Birnbaumer, Lutz; Garber, Alan J.

doi:10.1172/jci111286

Cited by 44 publications

(50 citation statements)

References 51 publications

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“…Such a loss of responsiveness is in agreement with similar data reported by other researchers in liver plasma membranes (Dighe et al, 1984), hepatocytes (Bathena et al, 1978 andChamras et al, 1980), hepatic slices (Yamashita et al, 1980) and cardiac membranes (Michel et al, 1985). One mechanism probably involved in the process could be the decreased number of glucagon receptors/cell detected by us in these animals, although a glucagoninduced desensitization of adenylate cyclase (Noda et al, 1984;Rich et al, 1984 andYamauchi andHashizume 1986) might also be involved.…”

Section: Discussionsupporting

confidence: 93%

“…and in liver plasma membranes (Allgayer et al, 1982 andDighe et al, 1984), although exceptions have also been observed (Davidson and Kaplan, 1977;Soman and Felig, 1978;Chamras et al, 1980 andSamson et al, 1982). Furthermore, the decrease in glucagon binding was higher than could be expected with a down-regulation process alone.…”

Section: Discussionmentioning

confidence: 85%

“…A decrease in adenylate cyclase activity stimulated by glucagon has been observed in liver plasma membranes (Dighe et al, 1984) hepatocytes (Bathena et al, 1978 andChamras et al, 1980), hepatic slices (Yamashita et al, 1980) and cardiac membranes (Michel et al, 1985). On the other hand, an increase in glucagon-stimulated adenylate cyclase activity was detected in liver plasma membranes (Soman andFelig., 1978 andAllgayer et al, 1982), and tivity to glucagon in the adipocytes of the diabetic rats as compared to the controls.…”

Section: Contradictorymentioning

confidence: 96%

“…In this sense, Ailgayer et al (1982) and Dighe et al (1984) observed a decrease in glucagon binding in liver plasma membranes of streptozotocindiabetic rats; Soman and Felig (1978) reported an increase; and Davidson and Kaplan (1977) described no alterations. Unaltered glucagon binding has been described in the hepatocytes of streptozotocindiabetic rats (Samson et al, 1982 andChamras et al, 1980) though Bathena et al (1978) detected a decrease.…”

Section: Contradictorymentioning

confidence: 96%

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Glucagon Binding and Lipolytic Response in Isolated Adipocytes from Streptozotocin-diabetic Rats.

Mayor

Calle

1988

Endocrinol Japon

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Evidence for pre-receptor, receptor and post-receptor glucagon defects was investigated in adipocytes from streptozotocin-diabetic rats. For this purpose male Wistar rats were injected by cardiac puncture with streptozotocin (65 mg/Kg body-weight) or saline solution and sacrificed after 7 and 15 days of drug administration.Increased glucagon levels and increased glucagon degradation in serum together with a decrease in glucagon binding were found in both groups of diabetic rats. The decrease in glucagon binding was related to a decrease in the number of glucagon receptors/cell rather than to a change in receptor affinity. The lipolytic response of glucagon was increased. However, the ability of glucagon to increase basal or theophylline-stimulated cAMP accumulation in the incubation medium of adipocytes from diabetic rats was decreased. Such alterations could represent a counter-regulatory mechanism of the hyperglucagonemia detected in streptozotocin-diabetic rats.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 85%

Section: Contradictorymentioning

confidence: 96%

Section: Contradictorymentioning

confidence: 96%

See 2 more Smart Citations

Glucagon Binding and Lipolytic Response in Isolated Adipocytes from Streptozotocin-diabetic Rats.

Mayor

Calle

1988

Endocrinol Japon

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“…It was reported that the accelerated proteolysis of uncontrolled diabetes is due to the deranged glucagon-mediated regulation of cAMP formation. 46) These are reflected by a considerable increase in the serum creatinine levels. The amount of serum creatinine is used to assess the renal function and to detect treatment-related toxic effects of compounds on the renal function of experimental rats.…”

Section: Discussionmentioning

confidence: 99%

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Al-Ali

Fatah

El‐Badry

2016

Biological & Pharmaceutical Bulletin

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Ultrasound-assisted extraction of curcumin from Curcuma longa was performed in an ultrasonic bath at 30°C using ethanol for 40 min. A successful attempt has been made to prepare curcumin-zinc (Zn) complex using a simple chemical procedure. The complex formation and its stoichiometry were characterized using elemental analysis, Fourier transform (FT)-IR and UV spectroscopy which revealed the interaction of Zn(II) ion (M) with curcumin (ligand, L) to proceed via (ML) complex type formation. Oral administration of curcumin-Zn complex at a concentration of 150 mg/kg body weight/rat/d for 45 d in streptozotocin-induced diabetic rats in comparison to curcumin and/or Zn administration exerted a hypoglycemic effect. A significant reduction in blood glucose, glycosylated hemoglobin (Hb)A1c, and lipid profile parameters with an excellent improvement in plasma insulin levels have been attained. Also, the reduced activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine in the diabetic rats treated with the complex exhibited the non-toxic nature of the curcumin-Zn complex. Finally, the larger extent of the complex in hyperglycemic improvement in comparison to curcumin and/or Zn supplementation was interpreted by its dual action on glucose and insulin maintenance.Key words diabetes; curcumin-zinc complex; dual action; curcumin; zinc metal; diabetes complication Diabetes mellitus, the most common endocrine disorder characterized by a state of chronic hyperglycemia and insulin resistance. Type 2 Diabetes Mellitus (T2DM) is projected to rise over 215 million people worldwide by the year 2010.

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Interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise

Wasserman

Vranić

1986

Diabetes Metab. Rev.

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Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus.

Cited by 44 publications

References 51 publications

Glucagon Binding and Lipolytic Response in Isolated Adipocytes from Streptozotocin-diabetic Rats.

Glucagon Binding and Lipolytic Response in Isolated Adipocytes from Streptozotocin-diabetic Rats.

Dual Effect of Curcumin–Zinc Complex in Controlling Diabetes Mellitus in Experimentally Induced Diabetic Rats

Interaction between insulin and counterregulatory hormones in control of substrate utilization in health and diabetes during exercise

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