Glucagon‐producingneuroendocrine tumour associated with hypoaminoacidaemia and skin lesions

Abstract

A nine-year-old neutered female crossbred Bernese mountain dog was diagnosed with superficial necrolytic dermatitis and a glucagon-producing islet cell tumour. Laboratory findings included hyperglucagonaemia and hypoaminoacidaemia. The dog was euthanased because of progression of the disease, and necropsy revealed liver metastases of a neuroendocrine carcinoma with immunohistochemical expression of glucagon and somatostatin. This report represents a case of canine glucagonoma syndrome; the previously reported cases in dogs are also briefly described.

Paraneoplastic Syndromes

“…1,[135][136][137] Marked fissuring, ulceration, and crusting of footpads have also been noted in dogs with SND. 1,[135][136][137] Marked fissuring, ulceration, and crusting of footpads have also been noted in dogs with SND.…”

Pancreas

“…Insulinomas are the most common of the three types of endocrine tumors in dogs. Superficial necrolytic dermatitis also known as hepatocutaneous syndrome or metabolic epidermal necrosis, was reported in several dogs with glucagonomas, 83,[93][94][95] but this syndrome has also been seen in dogs without glucagonomas. They were discovered incidentally during an examination for urinary tract calculi.…”

Necrolytic migratory erythema in a dog

“…In our case serum glucose, ALP, ALT and CK values increased. Anemia seems to be a commom feature of the syndrome in dogs (1). In this case, microcyticnormochromic anemia was determined.…”