Glucagon-like peptides 1 and 2

Gastrointestinal mucositis is a complex inflammatory reaction of the mucous membranes, a side effect of both chemotherapy and radiotherapy. Currently, assessment scales are used to diagnose mucositis. However, a biomarker which would determine whether there is mucositis and thereby establish the severity objectively would be very useful. This will give the opportunity to evaluate studies, to determine risk factors and incidence, and it will make it possible to compare studies. Moreover, this biomarker might improve clinical management for patients. In this paper, we reviewed studies concerning potential biomarkers in blood samples and fecal samples, and potential tests in breath samples and urine samples. We include biomarkers and tests studied in animal models and/or in clinical trials, and discuss the validity, diagnostic accuracy, and applicability.

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“…We speculate that future studies should determine the usefulness of one of these hormones as a biomarker for mucositis [67]. …”

Section: Discussionmentioning

confidence: 99%

Biomarkers and non-invasive tests for gastrointestinal mucositis

Kuiken

Rings

Blijlevens

et al. 2017

Support Care Cancer

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“…Mucositis is commonly believed to primarily impact the oral cavity, although it can also affect the entire GI tract [79][80][81]. GI toxicity may impair vital GI functions, resulting in microbial translocation with inflammatory and infectious consequences [79,[82][83][84][85][86]. Consequently, multiple studies have shown links between oral and intestinal toxicity generated by chemotherapy and unfavorable treatment outcomes, such as fever, severe infections, and overall death [78,82,87,88].…”

Section: Bc For Chemotherapy-induced Gi Toxicity In Acute Lymphoblast...mentioning

confidence: 99%

Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities

et al. 2022

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Worldwide, the incidence of cancer is on the rise. Current cancer treatments include chemotherapy, radiation therapy, and surgery. Chemotherapy and radiation treatment are typically associated with severe adverse effects and a decline in patients’ quality of life. Anti-cancer substances derived from plants and animals need to be evaluated therapeutically as it is cost-effective, have fewer side effects, and can improve cancer patients’ quality of life. Recently, bovine colostrum (BC) has attracted the interest of numerous researchers investigating its anti-cancer potential in humans. Dressings loaded with BC are beneficial in treating chronic wounds and diabetic foot ulcers. Lactoferrin, a glycoprotein with potent anti-oxidant, anti-inflammatory, anti-cancer, and anti-microbial effects, is abundant in BC. The BC pills successfully promote the regression of low-grade cervical intraepithelial neoplasia when administered intravaginally. The biological, genetic, and molecular mechanisms driving BC remain to be determined. Oral BC supplements are generally well-tolerated, but some flatulence and nausea may happen. To evaluate the therapeutic effects, long-term safety, and appropriate dosages of BC drugs, well-designed clinical trials are necessary. The purpose of this article is to emphasize the anti-cancer potential of BC and its constituents.

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“…(6-13) Important insight has also been provided on weight loss as well as nutrition support options for patients in need of supportive and palliative care. (14) (15, 16) Investigators and clinicians have also shared their valuable knowledge on novel approaches to understanding therapy related intestinal toxicities including symptom clustering(17), physiologic approaches(18), pathophysiologic mechanisims(19-22), new measurement tools/approaches(23-27) and understanding of therapy specific toxicities. (28, 29)…”

mentioning

confidence: 99%

Advances in understanding and improving gastrointestinal symptoms during supportive and palliative care

Ciorba

2016

Current Opinion in Supportive &Amp; Palliative Care

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Glucagon-like peptides 1 and 2

Cited by 14 publications

References 86 publications

Biomarkers and non-invasive tests for gastrointestinal mucositis

Biomarkers and non-invasive tests for gastrointestinal mucositis

Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities

Advances in understanding and improving gastrointestinal symptoms during supportive and palliative care

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