Glucagon-like peptide 2 (GLP-2) in bovine colostrum and transition milk

Abstract

Bovine colostrum contains growth factors, cytokines, hormones, and enzymes, which have important roles in stimulating gastrointestinal development of neonatal calves. In the present study, we measured the concentration of glucagon-like peptide 2 (GLP-2), one of the gut-derived peptides secreted from intestinal L-cells, in colostrum and transition milk of Japanese black cattle. All colostrum samples were collected within 24 h after calving (d 0) and transition milk was collected at 24, 48 and 72 h relative to the time at colostrum sampling (d 1, d 2 and d 3, respectively). Concentrations of GLP-2 in colostrum were 5.53 AE 1.07 ng/mL on average (range ¼ 0.94-9.60 ng/ mL) and decreased from d 0 to 3 (P < 0.01). Furthermore, concentrations of GLP-2 in colostrum and transition milk were quadratically decreased with the elapsed time from parturition until colostrum sampling (R 2 ¼ 0.48, P < 0.01). Our results show for the first time that GLP-2 is present in bovine colostrum and transition milk and that concentrations decreased with elapsed time from parturition.

Effect of Ca-octanoate supplementation on concentrations of ghrelin and ghrelin-related hormones in plasma and milk of beef cattle

“…Furthermore, concentrations of acylated ghrelin in colostrum were significantly higher than those in maternal plasma, which has been noted for other colostrum hormones, such as IGF-1 and insulin [ 8 , 39 ]. Higher concentrations of hormones in colostrum are not unusual because we have previously reported that concentrations of glucagon-like peptide 2, a gastrointestinal hormone, was also higher in colostrum than in maternal plasma of Japanese Black cattle [ 40 ]. In this study, concentrations of GH, IGF-1, and insulin in milk decreased with time after parturition.…”

Insights into the Research Trends on Bovine Colostrum: Beneficial Health Perspectives with Special Reference to Manufacturing of Functional Foods and Feed Supplements

“…The concentrations of IgG were 109.88 ± 3.04, 111.68 ± 2.15, and 110.63 ± 1.57 at homogenization levels of 10.34, 13.79, and 17.24 MPa, respectively [ 38 ]. Inabu et al [ 49 ] measured glucagon-like peptide 2 (GLP-2) in bovine colostrum and mature milk by employing solid-phase competition immunoassay. GLP-2 is one of the gut-derived peptides cosecreted with GLP-1 from intestinal L cells in response to nutrient absorption.…”