Glucagon-Like Peptide-2 and Short-Chain Fatty Acids: A New Twist to an Old Story

Tappenden, Kelly A.; Albin, David M.; Bartholome, Anne L.; Mangian, Heather

doi:10.1093/jn/133.11.3717

Cited by 80 publications

(62 citation statements)

References 24 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most surprisingly, this can even be observed on parenteral administration of SCFAs (111)(112)(113)(114)(115)(116). As such, it has been shown that parenteral SCFA administration stimulates glucagon-like peptide 2 from enteroendocrine cells (117). Glucagon-like peptide 2 has been credited as a driver of intestinal proliferation and differentiation (118).…”

Section: Modulation Of Gastrointestinal Physiology By Colonic Fermentmentioning

confidence: 99%

Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides

Oozeer¹,

Limpt²,

Ludwig³

et al. 2013

The American Journal of Clinical Nutrition

148

131

View full text Add to dashboard Cite

Human milk is generally accepted as the best nutrition for newborns and has been shown to support the optimal growth and development of infants. On the basis of scientific insights from human-milk research, a specific mixture of nondigestible oligosaccharides has been developed, with the aim to improve the intestinal microbiota in early life. The mixture has been extensively studied and has been shown to be safe and to have potential health benefits that are similar to those of human milk. The specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides has been found to affect the development of early microbiota and to increase the Bifidobacterium amounts as observed in human-milk-fed infants. The resulting gut ecophysiology is characterized by high concentrations of lactate, a slightly acidic pH, and specific short-chain fatty acid profiles, which are high in acetate and low in butyrate and propionate. Here, we have summarized the main findings of dietary interventions with these specific oligosaccharides on the gut microbiota in early life. The gut ecophysiology in early life may have consequences for the metabolic, immunologic, and even neurologic development of the child because reports increasingly substantiate the important function of gut microbes in human health. This review highlights major findings in the field of early gut colonization and the potential impact of early nutrition in healthy growth and development.Am J Clin Nutr 2013;98(suppl):561S-71S.

show abstract

Section: Modulation Of Gastrointestinal Physiology By Colonic Fermentmentioning

confidence: 99%

Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides

Oozeer¹,

Limpt²,

Ludwig³

et al. 2013

The American Journal of Clinical Nutrition

148

131

View full text Add to dashboard Cite

show abstract

“…166 It was responsive to enteral nutrition, 167 specific nutrients, 168 and products of fermentation. 169 In addition, circulating GLP-2 concentrations were correlated with bowel length, tolerance to enteral feeds, and nutrient absorptive capacity in infants with intestinal dysfunction. 170 …”

Section: Future Opportunities and Needsmentioning

confidence: 98%

Role of human milk components in gastrointestinal development: Current knowledge and future NEEDS

Donovan¹

2006

The Journal of Pediatrics

View full text Add to dashboard Cite

“…This primarily was due to the discovery that enteric peptides, such as glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide, and peptide YY, play key roles in the regulation of appetite, energy metabolism [15][16][17], and gut function [18][19][20], making them targets for managing prevalent human diseases of obesity and diabetes. As knowledge has continued to grow, the potential to improve gut function and health of food animals through the manipulation of enteric peptide secretion has become increasingly more apparent [21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals

Connor

Evock‐Clover

Wall³

et al. 2016

Domestic Animal Endocrinology

View full text Add to dashboard Cite

Numerous endocrine cell subtypes exist within the intestinal mucosa and produce peptides contributing to the regulation of critical physiological processes including appetite, energy metabolism, gut function, and gut health. The mechanisms of action and the extent of the physiological effects of these enteric peptides are only beginning to be uncovered. One peptide in particular, glucagon-like peptide 2 (GLP-2) produced by enteroendocrine L cells, has been fairly well characterized in rodent and swine models in terms of its ability to improve nutrient absorption and healing of the gut after injury. In fact, a long-acting form of GLP-2 recently has been approved for the management and treatment of human conditions like inflammatory bowel disease and short bowel syndrome. However, novel functions of GLP-2 within the gut continue to be demonstrated, including its beneficial effects on intestinal barrier function and reducing intestinal inflammation. As knowledge continues to grow about GLP-2's effects on the gut and its mechanisms of release, the potential to use GLP-2 to improve gut function and health of food animals becomes increasingly more apparent. Thus, the purpose of this review is to summarize: (1) the current understanding of GLP-2's functions and mechanisms of action within the gut; (2) novel applications of GLP-2 (or stimulators of its release) to improve general health and production performance of food animals; and (3) recent findings, using dairy calves as a model, that suggest the therapeutic potential of GLP-2 to reduce the pathogenesis of intestinal protozoan infections.

show abstract

Glucagon-Like Peptide-2 and Short-Chain Fatty Acids: A New Twist to an Old Story

Cited by 80 publications

References 24 publications

Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides

Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides

Role of human milk components in gastrointestinal development: Current knowledge and future NEEDS

Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals

Contact Info

Product

Resources

About