2020
DOI: 10.1002/1873-3468.13751
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Glucagon‐like peptide‐1 receptor undergoes importin‐α‐dependent nuclear localization in rat aortic smooth muscle cells

Abstract: Edited by Lukas Alfons HuberGlucagon-like peptide 1 receptor (GLP-1R) belongs to the family B of G protein-coupled receptors (GPCRs) and has antidiabetic and cardioprotective effects. Classical GLP-1R at the plasma membrane undergoes desensitization and internalization and is recycled back to the plasma membrane under the control of GLP-1 in islet b-cells. However, the subcellular localization of GLP-1R in the vascular system remains unclear. Here, we find that GLP-1R is localized in the nucleus of rat aortic … Show more

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Cited by 5 publications
(1 citation statement)
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“…By promoting the activity of growth factor receptors EGFR and HGFR, the α2-adrenergic receptor (α2-AR) promotes the proliferation of SMCs cells ( 20 ). Furthermore, the Glucagon-like peptide 1 receptor (GLP-1R) is located in the nucleus of rat SMCs, and artificially keeping it in the cytoplasm can promote the proliferation of SMCs ( 83 ). Together, these studies show that GPCRs are of profound significance to the occurrence and development of atherosclerosis, and the development of drugs targeting GPCRs to treat atherosclerosis is very necessary.…”
Section: Gpcrs In Vascular Function and Diseasementioning
confidence: 99%
“…By promoting the activity of growth factor receptors EGFR and HGFR, the α2-adrenergic receptor (α2-AR) promotes the proliferation of SMCs cells ( 20 ). Furthermore, the Glucagon-like peptide 1 receptor (GLP-1R) is located in the nucleus of rat SMCs, and artificially keeping it in the cytoplasm can promote the proliferation of SMCs ( 83 ). Together, these studies show that GPCRs are of profound significance to the occurrence and development of atherosclerosis, and the development of drugs targeting GPCRs to treat atherosclerosis is very necessary.…”
Section: Gpcrs In Vascular Function and Diseasementioning
confidence: 99%