Abstract:Glucagon‐like peptide‐1 (GLP‐1) can improve cardiac function and cardiovascular outcomes in diabetic cardiomyopathy; however, the beneficial effect of GLP‐1 on human diabetic cardiomyocytes (DCMs) and its mechanism have not been fully elucidated. Here, the DCMs model by human‐induced pluripotent stem cells‐derived cardiomyocytes is developed. Two subtypes of GLP‐1, GLP‐17–36 and GLP‐19‐36, are evaluated for their efficacy on the DCMs model. Diabetogenic condition is sufficient to induce most characteristics of… Show more
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