Glucagon Inhibition of Secretin and Combined Secretin and Cholecystokinin Stimulated Pancreatic Exocrine Secretion in Health and Disease

Clain, Jonathan E.; Barbezat, G. O.; Waterworth, M M; Bank, Sarbashri

doi:10.1159/000198089

Cited by 16 publications

(7 citation statements)

References 7 publications

(8 reference statements)

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“…In dog pancreas, glucagon mainly inhibits water and bicarbonate secretion in response to a meal (Singer et al 1978). However, results of studies conducted on human subjects are contradictory (Fontana et al 1975;Clain et al 1978). Presently, it is impossible to establish whether these effects are due to the direct binding of glucagon to duct cells or to a modulating action exerted on the pancreatic nervous system.…”

Section: Islet Influence On Pancreatic Duct Secretionmentioning

confidence: 99%

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Bertelli

Bendayan

2005

J Histochem Cytochem.

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S U M M A R YTraditional histological descriptions of the pancreas distinguish between the exocrine and the endocrine pancreas, as if they were two functionally distinct glands. This view has been proven incorrect and can be considered obsolete. Interactions between acinar and islet tissues have been well established through numerous studies that reveal the existence of anatomical and functional relationships between these compartments of the gland. Less attention, however, has traditionally been paid to the relationships occurring between the endocrine pancreas and the ductal system. Associations between islet tissue and ducts are considered by most researchers as only a transient epiphenomenon of endocrine development. This article reviews the evidence that has emerged in the last 10 years demonstrating the existence of stable, close, and systematic relationships between these two pancreatic compartments. Functional and pathophysiological implications are considered, and the existence of an "acinar-duct-islet" axis is put forward. The pancreas appears at present to be an integrated organ composed of three functionally related components of well-orchestrated endocrine and exocrine physiological responses.

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Section: Islet Influence On Pancreatic Duct Secretionmentioning

confidence: 99%

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Bertelli

Bendayan

2005

J Histochem Cytochem.

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“…On the one hand, an inhibition of the exogenously or endogenously stimulated volume and enzyme secretion has been observed in animals [16,23,34] and in man [4,6,14]. On the other hand, an increase in these parameters was also noted [21,23,26].…”

Section: Discussionmentioning

confidence: 95%

“…The conflicting observations concerning the effect of acetylcholine [9,13,22,27,31], gastrin [3,5,11,12,24,28,30,32], and glucagon [4,6,14,16,21,23,26,34] on the pancreas may be caused by the fact that these conditions were not or only partly fulfilled. Therefore, this study was directed to determine the action of these stimuli given alone or in combination with secretin (S) and cholecystokinin (CCK) in the isolated perfused pancreas and by use of dose-response curves.…”

Section: Introductionmentioning

confidence: 99%

Effect of acetylcholine, gastrin, and glucagon alone and in combination with secretin and cholecystokinin on the secretion of the isolated perfused rat pancreas

Sommer

Kasper

1981

Res. Exp. Med.

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Dose-response curves of acetylcholine (ACh), gastrin, and glucagon given alone or in combination with a submaximal dose of secretin (S;' 5.0 U/h) plus cholecystokinin (CCK; 1.0 U/h) were studied in the isolated perfused rat pancreas. ACh (25 x 10-9 mol/h) increased the basal secretory flow ( mean +/- SEM: 1.19 +/- 0.22 microliter/min) by 693% and protein output (2.7 +/- 0.2 microgram/min) by 1726%. The protein secretion evoked by S plus CCK was further increased by ACh to a maximum of 26% whereas the volume secretion remained unaltered. Gastrin (100 ng/h) stimulated the protein output by 352% and, when combined with S and CCK, up to further 23% and the secretory flow by 37%. Glucagon evoked a significant (P less than 0.005) increase of the protein output, but decreased the volume as well as the protein output (by 43% and 32%, respectively; P less than 0.05) when it was combined with the tested doses of S and CCK.

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“…The effect of glucagon on exocrine secretion has not yet been fully elucidated. Some studies have demonstrated inhibitory effects of glucagon on secretin- and cholecystokinin-stimulated pancreatic protein but not on bicarbonate secretion 5 , 6 , others showed that glucagon inhibits both postprandial protein and bicarbonate secretion 5 , 7 . However, more recent studies indicate that the effect of glucagon on isolated pancreatic acini appears to be direct and stimulatory, instead of inhibitory, suggesting complex action at the cellular versus physiological levels, with the inhibitory effects perhaps involving somatostatin release 5 , 8 .…”

Section: Introductionmentioning

confidence: 99%

Glucose homeostasis dependency on acini–islet–acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus

Pierzynowski

Gregory²,

Filip

et al. 2018

Nutr & Diabetes

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Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion independently of their digestive functions, both from the gut lumen and probably from the blood. As a result we would like to introduce here the concept of acini–islet–acinar (AIA) axis communication (feedback), which could play an important role in the development of obesity and diabetes type 2. The AIA feedback links the endocrine and exocrine parts of the pancreas and emphasizes the essential role that the pancreas plays, as a single organ, in the regulation of glucose homeostasis by amylase most probably in gut epithelium and by insulin and glucagon in peripheral blood.

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Glucagon Inhibition of Secretin and Combined Secretin and Cholecystokinin Stimulated Pancreatic Exocrine Secretion in Health and Disease

Cited by 16 publications

References 7 publications

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Effect of acetylcholine, gastrin, and glucagon alone and in combination with secretin and cholecystokinin on the secretion of the isolated perfused rat pancreas

Glucose homeostasis dependency on acini–islet–acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus

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