Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre‐eclamptic women without fetal growth retardation

Turan, Fahri; İlhan, Nevin; Kaman, Dilara; Ateş, Kadir; Kafkaslı, Ayşe

doi:10.1111/j.1447-0756.2010.01172.x

Cited by 19 publications

(10 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several polymorphisms in NOS3 gene were identified, of which three common functional polymorphisms were studied. These comprise the promoter -786T>C (rs2070744) single-nucleotide polymorphism (SNP) (Aggarwal et al, 2010;Lizbeth et al, 2011;Sandrim et al, 2010), the 4b/4a (rs61722009) variable number of 27 bp-repeat tandem repeats in intron 4 ( Rahimi et al, 2013;Sandrim et al, 2010;Singh et al, 2010), and the functional Glu298Asp (rs1799983) exon 7 variant, G to T substitution at nucleotide position 894 resulting in the replacement of glutamic acid with aspartic acid at codon 298 the Glu298Asp (Rahimi et al, 2013;Turan et al, 2010;Yu et al, 2006). However, conflicting and controversial results were reported among different studies.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

See 1 more Smart Citation

Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

Gannoun

Zitouni

Raguema

et al. 2015

Gene

View full text Add to dashboard Cite

Section: Accepted Manuscriptmentioning

confidence: 98%

“…Guo et al, 1999;Singh et al, 2010;Turan et al, 2010). Insofar as plasma NO levels are dependent on environmental and genetic factors, it was shown that-786T>C, Glu289Asp and 4b/4a NOS3 variants can alter the secretion and function ofNO (Deng et al, 2010; Zdoukopoulos et al, 2011).…”

mentioning

confidence: 95%

Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

Gannoun

Zitouni

Raguema

et al. 2015

Gene

View full text Add to dashboard Cite

“…Of those, seven studies were excluded (Kobashi et al, 2001;Grandone et al, 2003;Tempfer et al, 2004;Chen et al, 2007;Nishizawa et al, 2009;Singh et al, 2010;Sharma et al, 2011), because the distribution of the genotypes in the control group was not in HWE ( p < 0.05). Finally, 18 casecontrol studies were included in this meta-analysis (Yoshimura et al, , 2003Bashford et al, 2001;Tempfer et al, 2001;Hakli et al, 2003;Landau et al, 2004;Serrano et al, 2004;Hillermann et al, 2005;Fatini et al, 2006;Benedetto et al, 2007;Kim et al, 2008;Sandrim et al, 2008Sandrim et al, , 2010bSeremak-Mrozikiewicz et al, 2008;Aggarwal et al, 2010;Turan et al, 2010;Pappa et al, 2011;Salimi et al, 2011). All studies' characteristics and p-value for HWE from each study are listed in Table 1.…”

Section: Study Selectionmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase Gene Polymorphisms (G894T, 4b/a and T-786C) and Preeclampsia: Meta-Analysis of 18 Case–Control Studies

Chen

Zhao

Sun

et al. 2012

DNA and Cell Biology

View full text Add to dashboard Cite

Studies investigating the association between endothelial nitric oxide synthase (eNOS) gene polymorphisms and preeclampsia reported contradictory or nonconclusive results. We performed a meta-analysis of 18 genetic association studies that examined the relationship between preeclampsia and the G894T, 4a/b and T-786C polymorphisms of the eNOS gene. Subgroup analysis by ethnicity and potential sources of heterogeneity and bias were explored. The MEDLINE, EMBASE, and Google Scholar databases were searched to access the relevant genetic association studies up to June 2011. For the allelic analysis of the G894T variant, all studies showed no significant association. For the genotypic analysis, the combined studies of the G allele showed negative significance (odds ratio [OR]=0.56; 95% confidence interval [CI]: 0.33-0.97), all the studies showed positively significance when the T allele was combined (OR=1.17; 95% CI: 1.01-1.36), and results were also positively significant in non-Asian populations (OR=1.20; 95% CI: 1.02-1.43). For the allelic analysis of the 4b/a variant, all studies showed no significant association, but results were negatively significant in non-Asian populations (OR=0.67; 95% CI: 0.46-0.98). For the genotype analysis, combined studies of the b allele showed negative significance (OR=0.55; 95% CI: 0.36-0.84). Moreover, non-Asian studies showed negatively significant results (OR=0.45; 95% CI: 0.28-0.72). For the analysis of the T-786C variant, none of the studies showed significant results. The synthesis of available evidence supports the fact that intron 4a allele, homozygosity for the 894T and intron 4a of eNOS are positively associated with preeclampsia. Large, multiethnic confirmatory, and well-designed studies are needed to determine the relation between preeclampsia and polymorphisms of the eNOS gene.

show abstract

“…Several polymorphisms in NOS3 were identified in this study, among which, three common functional polymorphisms, the promoter -786T>C (rs2070744) SNP (Aggarwal et al, 2010), the 4b/4a (rs61722009) variable number of tandem repeats (27-bp repeat) in intron 4 (Singh et al, 2010;Rahimi et al, 2013), and the functional Glu298Asp (rs1799983) exon 7 variant (a G-to-T substitution at position 894 resulting in the replacement of glutamic acid with aspartic acid at codon 298) (Yu et al, 2006;Turan et al, 2010), were investigated. Recent clinical trials have proven the beneficiary effects of inhaled NO on respiratory syndromes (Schreiber et al, 2003;Ballard et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome

Wei

Wang

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Nitric oxide mediates multiple physiological functions, including neurotransmission, immune regulation, angiogenesis, antiplatelet activity, and surfactant maturation or secretion. Mice deficient in the nitric oxide synthase 3 (NOS3) gene displayed defective lung vascular development and fatal respiratory distress. Polymorphisms in NOS3 have been reported to be associated with respiratory distress syndrome (RDS). The role of NOS3 polymorphisms as a risk factor for pediatric acute respiratory distress syndrome (PARDS) was evaluated by analyzing the possible functional single nucleotide polymorphisms (SNPs) in the regulatory and coding regions of NOS3. Samples from 216 PARDS patients and 225 healthy control subjects were genotyped at 4 SNP loci (rs11771443 and rs3918188 in the promoter region, rs1799983 in exon 7, and rs7830 at the intron24-exon23 boundary). Statistically significant differences were observed in the allelic or genotypic frequencies of the rs1799983 and rs11771443 polymorphisms in NOS3. The T and G alleles of rs1799983 and rs11771443 were associated with a significantly higher risk of PARDS compared to the C allele (P = 0.030) and the T allele (P = 0.004), respectively. Strong linkage disequilibrium was observed in one block (D' > 0.9). Subjects with PARDS displayed significantly fewer T-C haplotypes (P = 0.013) in block 1 (rs1799983-rs11771443). These findings indicate that NOS3 polymorphisms play a definitive role in PARDS, and therefore may be useful for future genetic or neurobiological studies on RDS.

show abstract

Glu298Asp polymorphism of the endothelial nitric oxide synthase gene and plasma concentrations of asymmetric dimethylarginine in Turkish pre‐eclamptic women without fetal growth retardation

Abstract: The results suggested a lack of association between the Glu298Asp gene polymorphism and pre-eclampsia without FGR in the Turkish population. But elevated ADMA and SDMA levels suggest that ADMA has a role in the pathogenesis of PE.

Cited by 19 publications

References 45 publications

Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

Association of common eNOS/NOS3 polymorphisms with preeclampsia in Tunisian Arabs

Endothelial Nitric Oxide Synthase Gene Polymorphisms (G894T, 4b/a and T-786C) and Preeclampsia: Meta-Analysis of 18 Case–Control Studies

Association between functional polymorphisms in the nitric oxide synthase 3 gene and pediatric acute respiratory distress syndrome

Contact Info

Product

Resources

About