GLP and G9a histone methyltransferases as potential therapeutic targets for lymphoid neoplasms
Amandda Évelin Silva-Carvalho,
Luma Dayane Carvalho Filiú-Braga,
Gabriela Muller Reche Bogéa
et al.
Abstract:Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering the chromatin structure. Aberrant activation of HMTs has been widely reported in certain types of neoplastic cells. Among them, G9a/EHMT2 and GLP/EHMT1 are crucial for H3K9 methylation, and their dysregulation has been associated with tumor initiation and progression in different types of cancer. More recently, it has been shown that G9a and GLP appear to play a cr… Show more
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