GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota

Greiner, Thomas U.; Koh, Ara; Peris, Eduard; Bergentall, Mattias; Johansson, Malin E.V.; Hansson, Gunnar C.; Drucker, Daniel J.; Bäckhed, Fredrik

doi:10.1016/j.molmet.2024.101924

Molecular Metabolism

2024

DOI: 10.1016/j.molmet.2024.101924

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GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota

Thomas U. Greiner,

Ara Koh,

Eduard Peris

et al.

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2024

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Cited by 4 publications

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Vitamin A influences the incretin hormone profiles by activating the retinoic acid receptor β

Yu,

Chen,

Wang

et al. 2024

Journal of Diabetes and its Complications

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Vitamin A influences the incretin hormone profiles by activating the retinoic acid receptor β

Yu,

Chen,

Wang

et al. 2024

Journal of Diabetes and its Complications

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Immunomodulation and inflammation: Role of GLP-1R and GIPR expressing cells within the gut

Morrow,

Morissette,

Mulvihill

2024

Peptides

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Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

de Lima,

Moretti,

Torres Pomini

et al. 2024

Biology

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Glycolipid metabolic disorders (GLMDs) are various metabolic disorders resulting from dysregulation in glycolipid levels, consequently leading to an increased risk of obesity, diabetes, liver dysfunction, neuromuscular complications, and cardiorenal vascular diseases (CRVDs). In patients with GLMDs, excess caloric intake and a lack of physical activity may contribute to oxidative stress (OxS) and systemic inflammation. This study aimed to review the connection between GLMD, OxS, metainflammation, and the onset of CRVD. GLMD is due to various metabolic disorders causing dysfunction in the synthesis, breakdown, and absorption of glucose and lipids in the body, resulting in excessive ectopic accumulation of these molecules. This is mainly due to neuroendocrine dysregulation, insulin resistance, OxS, and metainflammation. In GLMD, many inflammatory markers and defense cells play a vital role in related tissues and organs, such as blood vessels, pancreatic islets, the liver, muscle, the kidneys, and adipocytes, promoting inflammatory lesions that affect various interconnected organs through their signaling pathways. Advanced glycation end products, ATP-binding cassette transporter 1, Glucagon-like peptide-1, Toll-like receptor-4, and sphingosine-1-phosphate (S1P) play a crucial role in GLMD since they are related to glucolipid metabolism. The consequences of this is system organ damage and increased morbidity and mortality.

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GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota

Cited by 4 publications

References 54 publications

Vitamin A influences the incretin hormone profiles by activating the retinoic acid receptor β

Vitamin A influences the incretin hormone profiles by activating the retinoic acid receptor β

Immunomodulation and inflammation: Role of GLP-1R and GIPR expressing cells within the gut

Glycolipid Metabolic Disorders, Metainflammation, Oxidative Stress, and Cardiovascular Diseases: Unraveling Pathways

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