Gloves and socks lymphangitis associated with acute parvovirus B19 infection

Eijnden, Serge Vanden; Carlier, F.R.I.C. Gwendoline I.M.; Beers, Danielle Van; Dangoisse, Chantal; Laet, Corinne De

doi:10.1046/j.1525-1470.2003.20221_4.x

Cited by 12 publications

(4 citation statements)

References 5 publications

(5 reference statements)

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“…Variants in the stereotypical pattern of cutaneous eruption (416)(417)(418)(419) have attracted the attention of dermatologists, usually as "glove-and-socks" syndromes (420,421). The characteristic distribution of glove and socks can be seen with papular, petechial, pustular, and bullous morphologies (422)(423)(424)(425)(426)(427)(428), even desquamation (429); concurrently in family members (430); and with oral lesions (431), lymphangitis (432), and vasculitic features (see below). Lymphadenopathy is present in some children with fifth disease (433)(434)(435), and presentation with enlarged lymph nodes and hepatosplenomegaly can mimic mononucleosis (436,437).…”

Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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Parvovirus B19 (B19V) and human bocavirus 1 (HBoV1), members of the large Parvoviridae family, are human pathogens responsible for a variety of diseases. For B19V in particular, host features determine disease manifestations. These viruses are prevalent worldwide and are culturable in vitro, and serological and molecular assays are available but require careful interpretation of results. Additional human parvoviruses, including HBoV2 to -4, human parvovirus 4 (PARV4), and human bufavirus (BuV) are also reviewed. The full spectrum of parvovirus disease in humans has yet to be established. Candidate recombinant B19V vaccines have been developed but may not be commercially feasible. We review relevant features of the molecular and cellular biology of these viruses, and the human immune response that they elicit, which have allowed a deep understanding of pathophysiology.

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Section: Clinical Manifestations Diseases Caused By B19v Infectionmentioning

confidence: 99%

Human Parvoviruses

2017

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“…Chlamydia suis when inoculated into weanling pigs produced a transmural enteritis with large lymphohistiocytic aggregates in the submucosa and lymphocytic aggregates that coursed through muscle coats and into the subserosa 34. Though not well appreciated, viruses can induce similar changes—for example, herpes viruses,35 adenoviruses36 and parvoviruses 37. In chronic hepatitis C, large aggregates of lymphocytes, often in a follicular pattern, occur in the portal tracks (lymphatics there)—a virus-induced lesion similar to those of the submucosa in Crohn’s disease 38.…”

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confidence: 99%

The forgotten role of lymphangitis in Crohn's disease

Kruiningen

Colombel

2007

Gut

119

109

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Research into Crohn's disease has recently been focused on the genetics of the patient, the gastrointestinal flora, the gut epithelium and mucosal immune responses. For over 60 years pathologists have reported that the fundamental alteration in Crohn's disease occurs in regional lymphatics of the intestine--the disease is a lymphocytic and granulomatous lymphangitis. At an earlier time, experimental sclerosis of regional intestinal lymphatics of the pig produced a chronic segmental enteritis with many features of Crohn's disease, including lymphocytic and granulomatous lymphangitis of the bowel wall and enteroenteric and enterocutaneous fistulas. In Crohn's disease, differences in the anatomic distribution of vasa recta appear to explain long-segment disease of the ileum and short-segment disease of the more proximal intestine. A variety of bacteria and viruses cause lymphangitis, suggesting that microorganisms may be at the centre of the basic changes in Crohn's disease. Dietary antigens and lipids are worthy of consideration as well. Now that antibodies to label lymphatics are available, attention should be directed at defining the initial damage to lymphatic endothelium and agents that might be responsible.

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“…723-727 A Degos-like presentation has been reported; it resulted from an underlying endothelialitis. 731 This exanthem usually occurs in adults, but childhood cases have been recorded. 729 The papular-purpuric 'gloves-and-socks' syndrome is a self-limited infection characterized by pruritic, erythematous papules with petechiae and edema involving predominantly the hands and feet.…”

Section: Parvovirus B19mentioning

confidence: 99%

Viral diseases

Weedon

2010

Weedon's Skin Pathology

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Gloves and socks lymphangitis associated with acute parvovirus B19 infection

Cited by 12 publications

References 5 publications

Human Parvoviruses

Human Parvoviruses

The forgotten role of lymphangitis in Crohn's disease

Viral diseases

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