Glomus tumor of the liver presenting as a cystic lesion

Kihara, Atsushi; Fukushima, Junichi; Horiuchi, Hajime

doi:10.1111/pin.12169

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…Folpe et al analyzed only three cases of visceral organ tumors (two in the lungs and one in the stomach), but did not analyze those without histological atypia [ 13 ]. Therefore, in agreement with Kihara et al [ 12 ], we believe that liver glomus tumors cannot be classified as malignant on the basis of their location and size alone, and that histological evaluation described in the other two criteria (ii) and (iii) should be of value. None of the five hepatic glomus tumor cases reported thus far have displayed histological abnormalities [ 7 – 12 ]; this is the first case arising in the liver with histological atypical features.…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, in agreement with Kihara et al [ 12 ], we believe that liver glomus tumors cannot be classified as malignant on the basis of their location and size alone, and that histological evaluation described in the other two criteria (ii) and (iii) should be of value. None of the five hepatic glomus tumor cases reported thus far have displayed histological abnormalities [ 7 – 12 ]; this is the first case arising in the liver with histological atypical features. In the atypical-looking lesion, mitotic figures were frequently seen (35/50 HPFs), but nuclear atypia was not higher than a typical malignant glomus tumor [ 14 ].…”

Section: Discussionsupporting

confidence: 90%

“…Glomus tumors arising in the liver are extremely rare. To our knowledge, only six cases have been reported in the English literature, including the case presented herein [ 7 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the glomus tumors reported in the liver to date are much larger than ordinary cutaneous glomus tumors (usually less than 1 cm). Kihara et al stated that glomus tumors arising in visceral organs may be diagnosed belatedly because they have less intense symptoms and are less palpable [ 12 ]. Folpe et al analyzed only three cases of visceral organ tumors (two in the lungs and one in the stomach), but did not analyze those without histological atypia [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

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Atypical glomus tumor arising in the liver: a case report

et al. 2015

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BackgroundGlomus tumors typically occur in the subcutaneous tissue of distal extremities, but rarely in visceral organs. Most glomus tumors are benign, while others have been reported to have malignant potential. Herein, a unique case of a liver glomus tumor with atypical histological features is reported.Case presentationA 39-year-old man felt fullness in the epigastrium, and an enhanced computed tomography (CT) scan of the abdomen and pelvis revealed a 21-cm solid and cystic mass in the left liver lobe. The patient underwent a left hepatic lobectomy, and the tumor was pathologically identified as a glomus tumor with atypical histological features in the liver. This case is unique for three reasons. First, cases of glomus tumors in the liver are extremely rare. Second, this is the first report of a hepatic glomus tumor with histologically atypical features. Third, immunohistochemical staining showed focal positivity for synaptophysin. A literature review revealed that glomus tumors in visceral organs positive for synaptophysin show histological atypical features in most cases.ConclusionsThis is the first case of a glomus tumor with atypical histological features arising in the liver. This unique case and literature review yielded interesting findings and enabled us to postulate that synaptophysin positivity may be indicative of atypical histological features in glomus tumors arising in visceral organs.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

“…Glomus tumors arising in the liver are extremely rare. To our knowledge, only six cases have been reported in the English literature, including the case presented herein [ 7 – 12 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Atypical glomus tumor arising in the liver: a case report

et al. 2015

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“…Seventy-five percent are subungual, however, these may pose a difficult diagnosing these tumors[3]. Although frequently found in the dermis, glomus tumors may occur in deep soft tissue or visceral sites throughout the body including lung, gastrointestinal, and liver[4,5]. Hypertrophy of a glomus body, an innervated, coiled, arteriovenous dermal shunt that normally controls skin temperature, is evident this tumor.…”

Section: Discussionmentioning

confidence: 99%

Glomus tumors of the fingers: Expression of vascular endothelial growth factor

Honsawek¹,

Kitidumrongsook²,

Luangjarmekorn³

et al. 2016

WJO

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Glomus tumors are uncommon, benign, small neurovascular neoplasms derived from glomus bodies in the reticular dermis. Glomus bodies are found throughout the body to regulate body temperature and skin circulation; however, they are concentrated in the fingers and the sole of the foot. The typical presentation is a solitary nodule in the subungual or periungual area of the distal phalanx. The primary treatment of choice is surgical removal. We investigated expression of vascular endothelial growth factor (VEGF) using immunohistochemistry in glomus tumors of the fingers. All five glomus tumor samples were positive for VEGF expression. VEGF immunoreactivity was largely localized to the cytoplasm of tumor cells, suggesting a contribution of VEGF to the vascularization of glomus tumors.

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Glomus Tumor and Glomangiopericytic Tumors of the Liver

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Glomus tumor of the liver presenting as a cystic lesion

Cited by 8 publications

References 6 publications

Atypical glomus tumor arising in the liver: a case report

Atypical glomus tumor arising in the liver: a case report

Glomus tumors of the fingers: Expression of vascular endothelial growth factor

Glomus Tumor and Glomangiopericytic Tumors of the Liver

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