Glomus tumor as a cause of oncogenic osteomalacia

Dehghani, Mehdi; Dabbaghmanesh, Mohammad Hossein; Khalafi-Nezhad, Abolfazl; Riazmontazer, N; Dehghanian, Amirreza; Vojdani, Reza; Sasani, Mohammad Reza

doi:10.11138/ccmbm/2017.14.3.359

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…An MRI scan revealed an in-homogenous lesion in the distal area of the left leg, posterior to the tibia. According to histopathological findings, the tumor was diagnosed as a GT [ 34 ]. Frumuseanu et al reported a tumor in the medial aspect of the right knee, on a 10-year-old boy’s leg after a fall.…”

Section: Discussionmentioning

confidence: 99%

Glomus tumors around or in the knee: a case report and literature review

Wang

et al. 2022

BMC Surg

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Background Glomus tumors commonly affect the extremities, especially subungual. And glomus tumors rarely occur around knee, which are often misdiagnosed. A lack of experience with glomus tumors is likely the cause. Case presentation A 42-year-old female presented with continuous dull pain of right knee for the past 7 years. Severe pain was experienced after walking a few hundred meters or climbing up or down stairs. The patient had a slight limp, and the lateral superior aspect of her right knee was tender to palpation. The range of motion and skin around her right knee were normal. Magnetic resonance imaging revealed a well-defined abnormal lesion confluent with the periosteum on the femoral lateral supracondylar. She was finally diagnosed with glomus tumor according to pathological results. After surgery, the pain disappeared, and the patient was discharged three days postoperatively. At the 18-month follow-up visit, the patient reported sustained pain relief, and regular follow-ups were continued. Additionally, 30 published reports documenting 36 cases of glomus tumors around the knee were reviewed, which showed that 20% of all reported cases of glomus tumor around the knee had a history of trauma. The median age for male with glomus tumor was greater than that of female; however, the median duration of illness between the two groups was equivalent. The mean diameters of glomus tumors ranged from 4 to 65 mm, and locations around the knee included the knee joint cavity, soft tissue (e.g. popliteal fossa, patellar tendon, iliotibial band, and Hoffa’s fat pad), distal femur, and proximal tibia. Conclusion Literature review demonstrated that no significant differences were found between male and female with glomus tumor in regard to location (left or right side) and illness duration. It was noting that a history of trauma may be a cause of glomus tumor and approximate 94.4% of glomus tumors was benign. The most effective therapy accepted for glomus tumors is complete surgical excision, and recurrence was rare after complete surgical excision.

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Section: Discussionmentioning

confidence: 99%

Glomus tumors around or in the knee: a case report and literature review

Wang

et al. 2022

BMC Surg

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“…Pain is the most obvious symptom of the disease, usually presenting as spontaneous tingling, extreme pain with the slightest touch, and intolerance to temperature changes[ 5 , 11 ]. In addition to these obvious symptoms, uncommon presentations such as tumor-induced osteomalacia were also reported, but more evidences are needed to support this discovery[ 12 ]. The disease diagnosis depends on clinical tests such as the Love test (point tenderness) and Hildreth's sign (decreased pain on exsanguination of the limb and application of a tourniquet)[ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Unusual glomus tumor of the lower leg: A case report

Wang¹,

Duan²,

Chen³

et al. 2022

WJCC

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BACKGROUND Glomus tumors are rare neoplasms, usually found on the fingers or toes. Glomus tumours that occur in the lower leg are even rarer and is likely to be misdiagnosed or underdiagnosed. This article will document the diagnosis, treatment, and follow-up of a rare glomus tumor of the lower leg, which had been misdiagnosed for up to 15 years. CASE SUMMARY The patient was a A 36-year-old woman who had suffered from localized pain in her left lower leg for 15 years. After a complete physical examination, a glomus tumor on her lower leg was considered and removed surgically. The specimen was pathologically diagnosed as a glomus tumor. There was no relapse at a 4-year follow-up. CONCLUSION Correct diagnosis and complete removal of the glomus tumor is important.

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“…A further MRI revealed an in-homogenous lesion in the distal area of the left leg, posterior to the tibia. The histopathological findings after complete surgical resection led to the definite diagnosis of GT (16). Another reported case was that of a GT in the medial aspect of the right knee, which appeared on the leg of a 10-year-old boy after a fall.…”

Section: Discussionmentioning

confidence: 99%

Glomus tumors associated with the bone and joints: a review of 91 cases

et al. 2020

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Background: Glomus tumors (GTs) commonly affect the subungual soft tissue but rarely affect the bone and joints. Meanwhile, GTs associated with the bone and joints have been misdiagnosed for decades. Methods:The PubMed, Embase, and Web of Science databases were searched, and primary data extracted from selected articles were quantitively analyzed.Results: The number of male and female patients was 52 and 39, respectively, and the right side was more commonly affected than the left. The median age at onset of male and female patients was 43.61±19.20 and 33.16±14.87 years, respectively, and the median illness duration was 3.00 (1.00, 10.00) and 3.00 (0.50, 7.50) years, respectively. The median follow-up time was 12 months, and the median time to recurrence or metastasis was also 12 months. Of the 91 total cases, 3 had a malignant pathological type and 4 had an uncertain malignant potential. Moreover, five cases recurred postoperatively, including two malignant cases, two benign GTs, and one case of glomangiomatosis. Of the 54 patients with recorded data on trauma, 12 reported a definite history of trauma.Conclusions: Interestingly, the history of trauma is an important cause of GTs. The most common site of extra-subungual tissue is the knee, especially in young adults. Surgical removal was the most commonly used treatment method, and radiotherapy and chemotherapy can be combined if necessary. Furthermore, patients should be followed up for at least 2 years postoperatively to monitor for possible recurrence. Fortunately, most patients with GTs have a good prognosis.

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Glomus tumor as a cause of oncogenic osteomalacia

Cited by 5 publications

References 15 publications

Glomus tumors around or in the knee: a case report and literature review

Glomus tumors around or in the knee: a case report and literature review

Unusual glomus tumor of the lower leg: A case report

Glomus tumors associated with the bone and joints: a review of 91 cases

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