Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria

Sun, Jun; Li, Mengfei; Zhu, Qianshen; Jia, Yuanyuan; Tian, Jing; Zhang, Chao

doi:10.1080/0886022x.2023.2188088

Cited by 1 publication

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sun et al . have reported that a high level of glomerulosclerosis was an independent risk factor for the prognosis of patients with pMN [ 20 ]. The deposition of subepithelial immune complexes in the glomerulus can affect podocyte and basement membrane attachment, and the detachment of epithelial cells and the GBM can cause glomerulosclerosis [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…The ability of FETP to predict the risk of renal failure remained unchanged when known risk factors, such as age, PCR, eGFR and treatment, were considered in the multivariate analysis. Clinical factors, such as older age [ 1 , 2 , 38 ], male sex [ 1 ], serum creatinine levels [ 1 , 2 , 3 ], the severity of proteinuria [ 2 , 38 , 39 ] and hypertension [ 39 ], and histological factors, such as the degree of tubulointerstitial damage [ 39 ] and glomerulosclerosis [ 20 ], have been reported as risk factors for renal prognosis in patients with pMN. Among all the predictive variables reported in previous studies, the most frequently used and reliable indicators were proteinuria and renal function variables [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…The exclusion criteria were as follows: age <18 years; unavailable clinical data; fewer than six glomeruli in kidney biopsy specimens; not first-onset pMN; follow-up time <6 months [ 1 ]; other diseases treated with prednisolone (PSL) or other immunosuppressants at that time or previously; and presence of secondary factors, including malignant tumors, rheumatic diseases, lupus erythematous, and hepatitis B or C virus infection as confirmed by blood testing, computed tomography and endoscopy [ 1 , 20 ].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Fractional excretion of total protein predicts renal prognosis in Japanese patients with primary membranous nephropathy

Kuno,

Kanzaki,

Sasaki

et al. 2024

Clinical Kidney Journal

View full text Add to dashboard Cite

Background Primary membranous nephropathy (pMN) is one of the most common types of glomerulonephritis, with a third of patients progressing to renal insufficiency. Various prognostic factors have been reported, of which urinary protein and renal function are the most critical parameters. Fractional excretion of total protein (FETP) indicates protein leakage that accounts for creatinine kinetics and serum protein levels. In this study, we investigated the association between FETP and renal prognosis in pMN. Methods We retrospectively identified 150 patients with pMN. FETP was calculated as follows: (serum creatinine × urine protein)/(serum protein × urine creatinine) %. We divided the patients into three groups according to FETP values and compared the clinicopathological findings. The primary outcome was an estimated glomerular filtration rate (eGFR) decrease of ≥ 30% from the baseline level. Results FETP was associated with urinary protein and renal function, Ehrenreich and Churg stage, and global glomerulosclerosis. The primary outcome was observed in 38 patients (25.3%), and the frequency of the primary outcome was higher in the higher FETP group (P = 0.001). FETP is higher than protein–creatinine ratio (PCR) in the area under the curve. In the multivariate analysis adjusted for age, eGFR, PCR, and treatment, FETP was significantly associated with primary outcome (adjusted hazard ratio, 8.19; P < 0.019). Conclusions FETP is a valuable indicator that can reflect the pathophysiology and is more useful than PCR as a predictor of renal prognosis in patients with Japanese pMN.

show abstract

Section: Discussionmentioning

confidence: 99%