Glomerulopathy Associated with Parasitic Infections

Velthuysen, Marie‐Louise F. van; Florquin, Sandrine

doi:10.1128/cmr.13.1.55-66.2000

Cited by 69 publications

(45 citation statements)

References 64 publications

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“…The main renal diseases associated with parasitic infections are mesangioproliferative glomerulonephritis or tubular necrosis; minimalchange disease or focal segmental glomerulosclerosis are found more rarely 19,20 . The majority of reports about renal lesions associated with toxoplasmosis refer to acute renal failure due to the deposition of sulfadiazine crystals in the urinary tract after treatment with this drug 20 .…”

Section: Discussionmentioning

confidence: 99%

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Nephrotic syndrome associated with toxoplasmosis: report of seven cases

Toporovski

Romano

Hartmann

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYThe concomitance of nephrotic syndrome and acute infection by Toxoplasma gondii is a rare occurrence in humans. In this paper seven cases of children, ranging from 11 months to 7 year-old, with concomitant nephrotic syndrome and asymptomatic acute T. gondii infection are reported. In one of those patients only the administration of anti-Toxoplasma therapy was enough to control the clinical and laboratory manifestations of the disease. In the other patients it was necessary to introduce corticosteroids or other immunosuppressant drugs. Three patients had complete clinical and laboratory improvement and the remaining showed only a partial response.

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Section: Discussionmentioning

confidence: 99%

“…The majority of reports about renal lesions associated with toxoplasmosis refer to acute renal failure due to the deposition of sulfadiazine crystals in the urinary tract after treatment with this drug 20 . However, the mechanisms of renal injury in the association of nephrotic syndrome and toxoplasmosis are not well understood.…”

Section: Discussionmentioning

confidence: 99%

Nephrotic syndrome associated with toxoplasmosis: report of seven cases

Toporovski

Romano

Hartmann

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…Renal involvement with peripheral eosinophilia can occur in a number of conditions like drugs [16], myeloproliferative disorders [17], parasitic manifestation [18], cholesterol embolization [19] or necrotizing vasculitis. No such cause was obvious from history and investigations in our case.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria

Shah¹,

Koul²,

Shah³

et al. 2013

OJNeph

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Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized by increased eosinophil count (eosinophilia) along with organ dysfunction secondary to organ infiltration of eosinophils and release of inflammatory markers [1][2][3][4], with no obvious cause for eosinophilia. The onset of symptoms is insidious in most of the cases and eosinophilia is detected incidentally. However, in others, the initial manifestations are severe and life-threatening due to the rapid evolution of cardiac or neurologic complications [5]. Renal involvement is rarely reported [6] in IHES. Herein we reported a case of IHES with predominant renal involvement as nephrotic syndrome with focal necrotizing IgA nephropathy.Keywords: Idiopathic Hypereosinophilic Syndrome; Eosinophilia; Renal Involvement; Nephrotic Syndrome Case ReportA 50-year old male presented with a 3-week history of a non-productive cough, associated with intermittent low grade fever, periorbital puffiness and lower extremity edema. Patient denied any history of breathlessness, chest-pain, hemoptysis, orthopnea, paroxysmal nocturnal dyspnea, drop in urine output, skin rash or arthritis. His past history was insignificant and he denied any history of drug intake.Hisexamination revealed mild pallor, with periorbitalpuffiness, lower extremity pitting edema and mild splenomegaly. He had hemoglobin of 11 g/dL with a total leucocyte count of 9.2 × 10 9 /cumm and an ESR of 23 mmhr. His differential count included 46% polymorphs 11% lymphocytes and 41% eosinophils with AEC count of 3800 which repeatedly was high and ranged from 3800 to 5500. A peripheral blood film showed features of normochromic normocytic anaemia with no abnormal cells. His serum creatinine was 1.7 mg/dL with a creatinine clearance of 44 ml/min. Liver functions showed hypoporoteinemia with hypoalbuminemia. He had an active urinary sedimentand urine which showed presence of eosinophils on wright's staining. 24 hours urinary protein was 5.04 g/24hours which was reproduced twice. Repeated stool examination for the presence of ova/parasite was negative.Radiograph of the chest was normal. High resolution computerized tomography of the chest did not reveal any abnormality. His electrocardiograph and echocardiography were normal. Ultrasonography of abdomen was normal as well.Patient was investigated further to look for eosinophilic infiltration of other organ systems in view of persistant hypereosinophilia.Patient was subjected to bronchoscopy to obtain bronchoalveolar lavage for eosinophils which revealed 62% eosinophils. Bone marrow aspiration and biopsy revealed 56% eosinophils with no dysplasia and blasts. p-ANCA andc-ANCA were within normal limits. Serum tryptase levels were within normal limits.Patient was subjected to percutaneous renal biopsy to look for the etiology of nephrotic range proteinuria. Renal biopsy revealed, marked interstitial edema and patchy inflammation including aggregates of eosinophils admixed with mononuclear cells and occasional neutrophils. An eosinophilic infiltrate wa...

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“…1 The most common manifestation is proteinuria, with or without nephrotic syndrome. Several histopathological types have been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…Several histopathological types have been demonstrated. [1][2][3] The pathogenesis of glomerular disease in patients with hydatid disease is not well understood, with most supporting an immune complex-mediated mechanism. Echinococcal antigen and corresponding antibody in the glomeruli have been demonstrated by immunoperoxidase studies.…”

Section: Discussionmentioning

confidence: 99%

Reversible nephrotic syndrome secondary to pulmonary hydatid disease

et al. 2010

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Development Goals or other campaigns. While facilitylevel staff are often urged to 'improve' performance, they have difficulty assessing quantitatively how their facility should contribute to the intended outcome of each strategic initiative. The tool uses data that are readily available to district managers for the purpose of setting targets, measuring progress and optimising resources at each facility.

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Glomerulopathy Associated with Parasitic Infections

Cited by 69 publications

References 64 publications

Nephrotic syndrome associated with toxoplasmosis: report of seven cases

Nephrotic syndrome associated with toxoplasmosis: report of seven cases

Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria

Reversible nephrotic syndrome secondary to pulmonary hydatid disease

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