Glomerulonephritis Associated with Inflammatory Demyelinating Polyradiculoneuropathy: A Case Report and Review of the Literature

Abstract

A patient developed relapsing inflammatory demyelinating polyradiculoneuropathy associated with nephrotic syndrome. Renal biopsy showed focal-segmental glomerulosclerosis. The review of the literature disclosed that glomerulonephritis with and without nephrotic syndrome seems to be not uncommon in inflammatory demyelinating polyradiculoneuropathy, such as Guillain-Barré syndrome. Membranous glomerulonephritis is the most frequent histologic diagnosis while minimal change nephropathy, ‘acute glomerulonephritis’ and postinfectious type glomerulonephritis are not often present. This is the first case of inflammatory demyelinating polyradiculoneuropathy associated with nephrotic syndrome due to focal-segmental glomerulosclerosis. Larger prospective studies are necessary and may contribute to the understanding of the pathogenesis of both, glomerulonephritis and inflammatory demyelinating polyradiculoneuropathy.

Guillain‐Barré syndrome patient weaned off ventilation after 22 months

“…8 On the other hand, the relationship between GBS and focal segmental glomerulonephritis seems anecdotal with only two case reports from the 1990s documenting this relationship between GBS and FSGS. 9,10 Our patient behaved similarly to these cases, showing improvement in the kidney function as he recovered from his GBS. Eventually, the deterioration in both renal and neurological states led to the patient's death.…”

Guillain-Barré Syndrome Associated with Minimal Change Glomerulopathy and Tubular Dysfunction – Related to Acetone-Based Organic Solvent?

“…The most prevalent histological characteristic in these cases is membranous glomerulopathy [8], while minimal change nephrotic syndrome or focal segmental glomerulosclerosis with Guillain-Barré syndrome has also occasionally been reported [9][10][11]. The neuritis and nephrosis are apparently related and may be mediated by disordered immunoregulations [8,9].…”

“…Reviewing pertinent literatures reveals that the simultaneous occurrence of Guillain-Barré and nephrotic syndrome has previously been reported [8][9][10][11]. The most prevalent histological characteristic in these cases is membranous glomerulopathy [8], while minimal change nephrotic syndrome or focal segmental glomerulosclerosis with Guillain-Barré syndrome has also occasionally been reported [9][10][11].…”

Minimal change nephrotic syndrome with Guillain-Barr� syndrome

“…Only a few cases of glomerulonephritis have been reported in the adult and pediatric literature [3,4,5]. We present the first case of an adolescent with GBS associated with minimal change nephrotic syndrome (MCNS) responsive to prednisone.…”