Glomerulonefrite aguda após infecção de vias aéreas superiores ou pele: análise descritiva de 82 pacientes entre 14 e 64 anos de idade

Abstract

Introduction: Acute glomerulonephritis (AGN) after infection of the upper airways or skin is a kidney disease usually caused by streptococcal nephritogenic strains and may present with sudden onset of gross hematuria, hypertension, edema and, occasionally, acute renal failure, is common in childhood and little incident in adults and younger individuals. Objective: To analyze, in a descriptive way, data from the initial presentation of GNA after infection of the upper airways or skin in patients over 14 years of age, with emphasis on its epidemiological and clinical aspects. Patients and Methods: We reviewed the clinical data of 82 patients treated at our department during the period 1972-2001, divided into three groups: group 1, with individuals between 14 and 20 years (n = 52), group 2, between 21 and 30 years (n = 19) and group 3, aged ≥; 31 years (n = 11). Results: There was a predominance of the table among younger patients (group 1), male and white, mostly preceded by infection of the skin, appearing most commonly on lower extremity edema and/or face. In some cases, even with nephrotic syndrome, and hypertension, especially in adults over 30 years (group 3), being the least frequent finding of gross hematuria, and rarely, acute renal failure. Conclusion: Our findings underscore the importance of studying the AGN after infection of the upper airways or skin in younger individuals and adults, seeking to better characterize its clinical, mainly because it is a group of patients where the disease is less incident.

Post-infective glomerulonephritis in children: a hospital based study

“…Our study, like others, showed edema, hematuria, hypertension and low complement level in significant number of patients. 7,[12][13][14] The low level of C 3 has been found to be one of the reliable indicators of PIGN. Most of our patients had significantly decreased C 3 level.…”

“…20 Study by Marques et al showed RPGN in 1.2% in age group beyond 14 years. 14 Journal of Patan Academy of Health Sciences. 2017 Jun;4(1):26-31.…”

Clinicopathological features of infection related glomerulonephritis in adult

“…Among their 102 infection related glomerulonephritis cases 56 (54.9%) were male and 46(45.09%) were female. Study conducted by Murmu and associates and Marques and associates [14,15] and Dhanapriya and associated [16] . Among the study population in 36.60% cases site of infection was unknown.…”

Pathological profiles of systemic infections by Panton‐Valentine leukocidin‐positive, methicillin‐resistant Staphylococcus aureus strains in a murine model

“…Considering the analysis of the kidneys in the histopathology examination all groups, it was observed intraglomerular congestion associated with bacterial colonization, a common aspect of infectious glomerulonephritis. Among some factors related to the onset of glomerulonephritis, the deposition of immunoglobulin G (IgG) or immune complexes due to microbial infection may be responsible to the renal failure, since activation of complement and generation of C5a may attract neutrophils to the glomeruli by chemotaxis, and thus prevent the proper function of the nephron (Marques et al 2010). This was more clearly observed in the group inoculated with BC01 PVL + , which also presented the highest counts in the kidney samples (10 7 CFU).…”