Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome

Phillips, Julie A.; Dixon, Julie; Richardson, Jeffrey B.; Fabré, Vilma C.; Callen, Jeffrey P.

doi:10.1016/j.jaad.2006.02.036

Cited by 27 publications

(29 citation statements)

References 26 publications

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“…9,22 Glomeruloid hemangiomas, histologically distinctive cutaneous angiomas associated with POEMS syndrome, have been reported as a specific marker for POEMS. 23 Our patient's biopsy specimen was consistent with that of a capillary angioma and lacked glomeruloid features.…”

Section: Discussionmentioning

confidence: 99%

IgM-λ paraproteinemia with associated cutaneous lymphoplasmacytic infiltrate in a patient who meets diagnostic criteria for POEMS syndrome

Colaco

Miller

Ruben

et al. 2008

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

IgM-λ paraproteinemia with associated cutaneous lymphoplasmacytic infiltrate in a patient who meets diagnostic criteria for POEMS syndrome

Colaco

Miller

Ruben

et al. 2008

Journal of the American Academy of Dermatology

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“…A review of the pertinent literature revealed 25 previously published cases, 16 of which were associated with the syndrome, while in 5 cases Castleman's disease was also present. [2][3][4][5][6][7][8][9] In one case, a diagnosis of Castleman's disease was made but the minimum criteria for a diagnosis of POEMS syndrome were not present; however, the patient continued to be monitored. 4 GH may sometimes precede the other signs and symptoms of this syndrome, permitting an early diagnosis to be reached or constituting a link between a constellation of clinical findings that, in principle, may appear to be unrelated to each other.…”

Section: Hemangiomas In Poems Syndromementioning

confidence: 99%

Hemangioma glomeruloide e a síndrome POEMS: relato de dois casos e revisão da literatura

Jeunon

Sampaio

Caminha

et al. 2011

An. Bras. Dermatol.

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O hemangioma glomeruloide caracteriza-se por enovelados capilares contidos em espaços vasculares dilatados reminiscentes de glomérulos renais, sendo fortemente associado à síndrome POEMS (polineuropatia, organomegalia, endocrinopatia, gamopatia monoclonal e alterações cutâneas). Relatamse dois casos da síndrome associados a hemangiomas glomeruloides e faz-se uma revisão da literatura. O primeiro é uma paciente feminina, 63 anos, internada para investigação de ascite, hepatoesplenomegalia, dificuldade de deambulação e hemangiomas cutâneos. A histopatologia de uma dessas lesões estabeleceu o diagnóstico de hemangioma glomeruloide e direcionou a investigação, que revelou polineuropatia sensitivo-motora, plasmocitoma kappa-positivo em L4 e Diabetes mellitus, permitindo o diagnóstico da síndrome. O segundo caso é de uma paciente feminina, 39 anos, com edema, ascite, derrame pleural, hemangiomas glomeruloides e linfonodomegalias (doença de Castleman). Havia um componente monoclonal de IgG-lambda e lesões blásticas no ilíaco direito e em L4, assim como lesão desmielinizante sensitivo-motora nos quatro membros, compondo o diagnóstico de síndrome POEMS.

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“…[7][8][9][10] Still, in the setting of polyneuropathy, big organs, myeloma protein production, and the specified range of skin changes, GHs have been regarded as a specific marker for POEMS syndrome. 4,5,11,12 The first case of GH not associated with POEMS syndrome was described in 2005 13 ; 3 more were reported in 2007. 14 In addition, 11 recently reported histologically identical cases were designated as papillary hemangioma, 6 all without association with POEMS syndrome.…”

Section: Introductionmentioning

confidence: 99%

Eosinophilic Globules in 3 Cases of Glomeruloid Hemangioma of the Head and Neck: A Characteristic Offering More Evidence for Thanatosomes With or Without POEMS

Lee

Meier

Chan

et al. 2008

The American Journal of Dermatopathology

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Glomeruloid hemangiomas (GHs) are glomeruli-like capillary tufts lined by endothelial cells that contain periodic acid-Schiff (PAS) positive eosinophilic globules (EGs). These hemangiomas are characteristic cutaneous manifestation of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, and Skin changes). Hemangiomas histologically identical to GHs but not associated with POEMS have recently been designated as papillary hemangiomas. In this report, we present solitary head and neck GHs in 3 patients, 2 without POEMS, with particular attention to the characteristic EGs. We performed immunostains for hemoglobin A, kappa and lambda light chains, factor VIII-related antigen, CD31 and CD34, PAS stain after diastase digestion (PASD), and electron microscopic examinations on routinely fixed tissues containing EGs. Eosinophilic globules stained uniformly positive for PASD but only peripherally positive for hemoglobin and light chains on surfaces, with interiors negative for antigens. Factor VIII-related antigen and CD31 and CD34 confirmed cells containing EGs to be endothelial. Electron microscopic examination suggested that EGs are enlarged secondary lysosomes (thanatosomes). These features fail to support red blood cells or immunoglobulins as EG constituents. Glomeruloid hemangiomas may be vascular proliferations stimulated by endothelial cells' protein phagocytosis but not by phagocytosis of either hemoglobin-containing red blood cells or immunoglobulins. The vascular lesions in POEMS syndrome appear identical to papillary hemangioma in cases without the other syndromic manifestations.

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Glomeruloid hemangioma leading to a diagnosis of POEMS syndrome

Cited by 27 publications

References 26 publications

IgM-λ paraproteinemia with associated cutaneous lymphoplasmacytic infiltrate in a patient who meets diagnostic criteria for POEMS syndrome

IgM-λ paraproteinemia with associated cutaneous lymphoplasmacytic infiltrate in a patient who meets diagnostic criteria for POEMS syndrome

Hemangioma glomeruloide e a síndrome POEMS: relato de dois casos e revisão da literatura

Eosinophilic Globules in 3 Cases of Glomeruloid Hemangioma of the Head and Neck: A Characteristic Offering More Evidence for Thanatosomes With or Without POEMS

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