Glomeruloid Hemangioma and POEMS Syndrome

Red Nodule on the Scalp in a Healthy Young Man

“…Clinically, GH presents as multiple, small, red papules on the trunk and limbs, with a rapid onset of days or few weeks. 6,7 In contrast, PH presents in adults as a solitary tumor on the head and neck. Additionally, GH is considered to be a hallmark finding of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes) 6 and TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly) syndromes.…”

“…6,7 In contrast, PH presents in adults as a solitary tumor on the head and neck. Additionally, GH is considered to be a hallmark finding of POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes) 6 and TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly) syndromes. PH has no associated underlying diseases.…”

“…GH is the most important PH histopathological differential diagnosis because both conditions show a proliferation of capillary vessels within a dilated vascular structure and hyaline globules; however, its clinical presentation and associated diseases differ. Clinically, GH presents as multiple, small, red papules on the trunk and limbs, with a rapid onset of days or few weeks . In contrast, PH presents in adults as a solitary tumor on the head and neck.…”

“…On dermoscopic examination, GH displays red lacunae and/or red-white backgrounds, linear irregular vessels, and red rounded structures . In the present case, PH dermoscopic findings showed red lacunae without septa, white structureless areas, and irregular vessels.…”

Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?

“…Estos últimos son específicos de POEMS, se producirían por altos niveles de VEGF, y se manifiestan como pápulas o placas angiomatosas múltiples, firmes, cupuliformes y diseminadas en tronco y raíz de extremidades. A la histopatología, se caracterizan por nidos de capilares sanguíneos dentro de vasos dérmicos dilatados, que recuerdan a los glomérulos renales 44 . Otras manifestaciones cutáneas incluyen hipertricosis, cambios esclerodermiformes, plétora facial, acrocianosis, fenómeno de Raynaud, flushing y leuconiquia 5 .…”