Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study

Mulder, Renée L.; Knijnenburg, Sebastiaan L.; Geskus, Ronald B.; Dalen, Elvira C. van; Pal, Helena J.H. van der; Koning, Caro C.E.; Bouts, Antonia H.; Caron, Huib N.; Kremer, Leontien C. M.

doi:10.1158/1055-9965.epi-13-0036

Cited by 50 publications

(61 citation statements)

References 36 publications

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“…Most neuroblastoma patients typically require adjuvant chemotherapy, stem-cell treatment and abdominal radiation, all of which can impair function of the remaining kidney[11, 12]. Mulder et al reported early and persistent impaired glomerular function in childhood cancer survivors treated with ifosfamide, high doses of cisplatin and nephrectomy[13]. Thus, identifying risk of nephrectomy prior to resection will aid in planning future therapy and management.…”

Section: Discussionmentioning

confidence: 99%

Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection

Lim

Goldman

Farber

et al. 2016

Journal of Pediatric Surgery

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Background Although nephrectomy rates are higher in children with neuroblastoma who have image-defined risk factors and/or high-risk disease who undergo resection prior to chemotherapy, no published data outline the key radiographic and clinical characteristics associated with nephrectomy. Methods With IRB approval, imaging studies of children undergoing primary resection of intra-abdominal neuroblastoma between 2000 and 2014 were retrospectively reviewed. Fisher’s exact and Wilcoxon rank-sum tests were used to compare categorical and continuous variables, respectively, with p-values adjusted for multiple testing using the false discovery rate approach. Results Twenty-seven of 380 consecutive patients with CT imaging obtained prior to primary neuroblastoma resection underwent partial or total nephrectomy. On preoperative imaging, renal vessel narrowing and encasement and tumor invasion of the renal hilum, pelvis, and/or parenchyma were present significantly more frequently among patients undergoing nephrectomy. Delayed renal excretion of contrast, hydronephrosis, and tumors with MYCN amplification were also more prevalent in the nephrectomy group. Conclusion Encasement and narrowing of renal vessels, delayed excretion, and tumor invasion into the kidney, particularly pelvis and capsule invasion, are significantly associated with partial or total nephrectomy at initial neuroblastoma resection. These observations provide valuable information for surgical planning as well as presurgical discussions with families prior to neuroblastoma resection.

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Section: Discussionmentioning

confidence: 99%

Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection

Lim

Goldman

Farber

et al. 2016

Journal of Pediatric Surgery

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“…In our opinion, from the viewpoint of renal function and long-term survival among uninephrectomized WT patients, the above statement is neither certain nor obvious. There are few long-term studies that evaluate the renal function in adult WTS , and we do not have sufficient scientific evidence that confirms the validity of this thesis (4,(32)(33)(34). Certainly, solitary kidney is a risk factor for the progression of CKD.…”

Section: Chronic Kidney Disease In Wtsmentioning

confidence: 84%

“…Signs of kidney damage may indicate the risk of deterioration of kidney function in the future. Long-term monitoring of renal function in WTS will facilitate the identification of those with treatmentrelated impairment of function.WTS are at risk of deterioration of renal function and CKD because of the following: decreased number of nephrons -after nephrectomy, nephrotoxic side effects of chemotherapy (carboplatin, cisplatin, ifosfamide, cyclophosphamide) or radiation therapy -if solitary kidney was in the field of radiation (3,4,26,27). According to Daw et al (3), the most severe reduction in GFR, measured by 99Tc-DTPA (technetium-99m-diethylenetriamine pentaacetic acid) clearance, occurs after nephrectomy.…”

Section: Chronic Kidney Disease In Wtsmentioning

confidence: 99%

“…The number of survivors who have completed this treatment is increasing. All treatments can have potential long-term influence on the renal function of WT survivors (WTS) (2)(3)(4). A wide range of defects in kidney structure and function, from end-stage renal disease (ESRD) to varying degrees of chronic kidney disease (CKD), have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…A wide range of defects in kidney structure and function, from end-stage renal disease (ESRD) to varying degrees of chronic kidney disease (CKD), have been reported. CKD is associated with an increased risk of cardiovascular events, hospitalization and higher mortality (4,5). The incidence and causes of renal dysfunctions vary depending on distinct clinical situations: sporadic (nonsyndromic) unilateral WT (UWT), sporadic bilateral WT (BWT) and WT arising in patients with genetic predisposition syndromes.…”

Section: Introductionmentioning

confidence: 99%

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Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

Stefanowicz

Kosiak

et al. 2016

Wilms Tumor

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Licence: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Users are allowed to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material for any purpose, even commercially), as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. AbstractCurrently, the treatment of Wilms tumour (WT) is successful in approximately 90% of cases, and consists of chemotherapy, nephrectomy, and, in some cases, radiation therapy. All treatments have potential long-term influence on the function of solitary kidneys in WT survivors (WTS). Severe reduction in glomerular filtration rate occurs after nephrectomy. All patients who underwent surgical treatment for WT could be considered to have 132a risk of chronic kidney disease (CKD) because they lack a kidney. End-stage renal disease is rare (1.8% of National Wilms Tumour Study patients). Recent studies have revealed that patients with CKD have a greater risk of cardiovascular events and death. Most of the WTS have lower stages or no CKD. Regular biochemical studies and ultrasound examination at follow-up visits should be considered as indispensible elements of long-term care in uninephrectomized WTS. The evaluation of a single kidney function should be frequent, consisting of the assessment of estimated glomerular filtration rate (eGFR), assessment of albumin urine excretion, urine sediment analysis to detect abnormalities, ultrasound examination and measurements of blood pressure. According to Kidney Disease Improving Global Outcomes (KDIGO) recommendation and suggestions, GFR should be assessed using GFR-estimating equations that include serum creatinine and cystatin C concentrations. Cystatin C can be a more sensitive marker of kidney filtration function than creatinine, especially in diseases characterized by a mild decrease in glomerular filtration. This will facilitate the detection of early kidney impairment and assessment of the progression of CKD in WTS.

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Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer

Kooijmans

Bökenkamp

Tjahjadi

et al. 2019

Cochrane Database of Systematic Reviews

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Glomerular Function Time Trends in Long-Term Survivors of Childhood Cancer: A Longitudinal Study

Cited by 50 publications

References 36 publications

Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection

Image-defined risk factors for nephrectomy in patients undergoing neuroblastoma resection

Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

Early and late adverse renal effects after potentially nephrotoxic treatment for childhood cancer

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