Glomerular function and hyperuricaemia in sickle cell disease.

Morgan, A G; Ceulaer, Karel De; Gr, Serjeant

doi:10.1136/jcp.37.9.1046

Cited by 12 publications

(8 citation statements)

References 10 publications

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“…Values for creatinine in both Hb AS and Hb SS with out enzyme deficiency were lower than in normal control (p < 0.05). These values are in close agreement with those reported elsewhere [6,13]. However, in Hb AS and Hb SS subjects with G6PD deficiency, the mean levels of creati nine were significantly higher than in subjects without enzyme deficiency (p < 0.05).…”

Section: Hb S S Saudi Subjectssupporting

confidence: 82%

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Uric Acid, Creatinine and Urea in Normal, Glucose-6-Phosphate Dehydrogenase-Deficient and Hb SS Saudi Subjects

et al. 1995

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Section: Hb S S Saudi Subjectssupporting

confidence: 82%

“…Hyperuricemia has been reported to be a common fea ture of homozygous sickle cell disease, occurring in 41% of patients [13][14][15]. This has been attributed to the mark edly increased red cell turnover and decreased renal Values are the mean ± SD.…”

Section: Hb S S Saudi Subjectsmentioning

confidence: 99%

Uric Acid, Creatinine and Urea in Normal, Glucose-6-Phosphate Dehydrogenase-Deficient and Hb SS Saudi Subjects

et al. 1995

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“…Earlier study has shown that an otherwise clinically stable adult SCD patient NS not significant, Y yes, N no, M male, F female, PAH pulmonary arterial hypertension, UA uric acid, PASP pulmonary artery systolic pressure, SS Hemoglobin SS, SC Hemoglobin SC maintains normouricemia by increasing renal UA clearance [16]. Additionally, SCD patients with tubular proteinuria did not have significantly higher UA concentrations than others [17]. Therefore, an elevated UA in SCD patients could point toward its pathophysiological importance.…”

Section: Discussionmentioning

confidence: 90%

Uric Acid as a Potential Biomarker of Pulmonary Arterial Hypertension in Patients with Sickle Cell Disease

Joshi

Anjum

Gowda

et al. 2011

Indian J Hematol Blood Transfus

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Serum uric acid (UA) is emerging as a strong and independent marker for pulmonary arterial hypertension (PAH). PAH is well recognized as a life threatening complication of sickle cell disease (SCD). However, the association between UA and PAH in SCD is unknown. We reviewed electronic medical records (EMR) of 559 consecutive adult SCD patients from Kings County Hospital Center (KCHC) between January 2005 and February 2010. Patients (n = 96) with measurement of UA in close temporal proximity to the transthoracic echocardiography (TTE) were identified. PAH was defined as pulmonary artery systolic pressure (PASP) C30 mm Hg. Patients (n = 16) with other risk factors which may cause PAH and chronic renal insufficiency were excluded. In 18 patients, TTE could not measure PASP. Finally, 62 patients were selected. Statistical analysis was performed using Student t tests, Pearson correlation coefficient and multivariate regression analysis. Out of 62 patients, 30 had PAH. Patients with PAH had a higher UA level (8.67 ± 4.8 vs. 5.35 ± 2.1, P = 0.001). We found strong positive correlation between the UA level and PASP (r = 0.71; P \ 0.0001). This correlation was independent of diuretic use. UA could be a potential marker for PAH in SCD. However, its' prognostic and pathophysiologic role in SCD patients with PAH needs to be further investigated.

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“…This finding contrasts with previous studies (Manfredini et al , ; Alsultan et al , ) and could result from the higher level of plasma antioxidant power found in SCA patients, which could have mitigated the AOPP‐specific production pathway in situ (Pialoux et al , ). The greater level of FRAP found in the SCA group compared to healthy subjects may be partly explained by the hyperuricaemia described in SCA patients (Morgan et al , ). Similarly to the FRAP results, and in agreement with the data reported by Manfredini et al () and Rusanova et al (), the activity of the GPX anti‐oxidant enzyme was significantly higher in our SCA patients.…”

Section: Discussionmentioning

confidence: 92%

Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation

et al. 2013

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SummaryVery few studies have investigated the effects of exercise on the biological parameters involved in vaso-occlusive events in sickle cell anaemia (SCA). The aim of this study was to test how a mild-moderate endurance exercise modulates oxidative stress, nitric oxide bioavailability and endothelial activation in SCA patients and healthy individuals. Eleven patients with SCA and 15 healthy subjects completed a 20-min duration submaximal cycling exercise at %45 Watts. Plasma markers of oxidative stress, antioxidant activity, endothelial activation and nitric oxide bioavailability were investigated before and after the exercise. Nitric oxide levels, anti-oxidant capacity, soluble (s)E-selectin and sP-selectin did not change in response to this exercise. Except for the malondialdehyde levels, which increased in the two groups, the other markers of oxidative stress remained unchanged in both groups in response to exercise. Soluble vascular cell adhesion molecule 1 levels were increased at the end of exercise in both groups. sL-selectin decreased and soluble intercellular adhesion molecule 1 increased with exercise in SCA patients only. The present data suggest that patients with SCA may undertake mild-moderate physical activities without any acute clinical complications, but care should be taken because oxidative stress and endothelial activation significantly increased in some patients.

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Glomerular function and hyperuricaemia in sickle cell disease.

Abstract: SUMMARY Renal insufficiency is common in adults with homozygous sickle cell disease, and the contribution of glomerular failure to the hyperuricaemia which is often a feature of the disease has therefore been investigated. In a study of 64

Cited by 12 publications

References 10 publications

Uric Acid, Creatinine and Urea in Normal, Glucose-6-Phosphate Dehydrogenase-Deficient and Hb SS Saudi Subjects

Uric Acid, Creatinine and Urea in Normal, Glucose-6-Phosphate Dehydrogenase-Deficient and Hb SS Saudi Subjects

Uric Acid as a Potential Biomarker of Pulmonary Arterial Hypertension in Patients with Sickle Cell Disease

Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation

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