Glomerular Filtration Rate Measured by Using Triphasic Helical CT with a Two-Point Patlak Plot Technique

Hackstein, Nils; Wiegand, Cornelia; Rau, W. S.; Langheinrich, Alexander C.

doi:10.1148/radiol.2301021266

Cited by 57 publications

(39 citation statements)

References 17 publications

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“…onstrated that GFR can be measured accurately with triphasic CT (4). In addition, Patlak et al developed a model for determining tissue function based on contrast transfer between tissues; this technique has been extrapolated to renal function in several studies (5).…”

Section: Clinical Urolo�y Clinical Urolo�ymentioning

confidence: 99%

Renal parenchyma thickness: a rapid estimation of renal function on computed tomography

et al. 2009

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Purpose: To define the relationship between renal parenchyma thickness (RPT) on computed tomography and renal function on nuclear renography in chronically obstructed renal units (ORUs) and to define a minimal thickness ratio associated with adequate function. Materials and Methods: Twenty-eight consecutive patients undergoing both nuclear renography and CT during a six-month period between 2004 and 2006 were included. All patients that had a diagnosis of unilateral obstruction were included for analysis. RPT was measured in the following manner: The parenchyma thickness at three discrete levels of each kidney was measured using calipers on a CT workstation. The mean of these three measurements was defined as RPT. The renal parenchyma thickness ratio of the ORUs and non-obstructed renal unit (NORUs) was calculated and this was compared to the observed function on Mag-3 lasix Renogram. Results: A total of 28 patients were evaluated. Mean parenchyma thickness was 1.82 cm and 2.25 cm in the ORUs and NORUs, respectively. The mean relative renal function of ORUs was 39%. Linear regression analysis comparing renogram function to RPT ratio revealed a correlation coefficient of 0.48 (p < 0.001). The linear regression equation was computed as Renal Function = 0.48 + 0.80 * RPT ratio. A thickness ratio of 0.68 correlated with 20% renal function. Conclusion: RPT on computed tomography appears to be a powerful predictor of relative renal function in ORUs. Assessment of RPT is a useful and readily available clinical tool for surgical decision making (renal salvage therapy versus nephrectomy) in patients with ORUs.

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Section: Clinical Urolo�y Clinical Urolo�ymentioning

confidence: 99%

Renal parenchyma thickness: a rapid estimation of renal function on computed tomography

et al. 2009

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“…This method has been shown to be useful for quantification of blood flow, blood volume, and permeability in other organs. [32][33][34] The Patlak plot method 35,36 is based on a two-compartment pharmacokinetic model and permits the calculation of K1, which is the first-order transfer constant from LV blood to myocardium. The Patlak plot method plots the change in myocardial attenuation on the y-axis versus the area under the arterial blood pool TAC (Figure 4).…”

Section: Dynamic Ct Perfusion Imagingmentioning

confidence: 99%

Quantitative and qualitative analysis and interpretation of CT perfusion imaging

Valdiviezo

Ambrose

Mehra

et al. 2010

Journal of Nuclear Cardiology

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Coronary artery disease (CAD) remains the leading cause of death in the United States. Rest and stress myocardial perfusion imaging has an important role in the non-invasive risk stratification of patients with CAD. However, diagnostic accuracies have been limited, which has led to the development of several myocardial perfusion imaging techniques. Among them, myocardial computed tomography perfusion imaging (CTP) is especially interesting as it has the unique capability of providing anatomic- as well as coronary stenosis-related functional data when combined with computed tomography angiography (CTA). The primary aim of this article is to review the qualitative, semi-quantitative, and quantitative analysis approaches to CTP imaging. In doing so, we will describe the image data required for each analysis and discuss the advantages and disadvantages of each approach.

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“…Functional techniques that have been described include MR renography (3,(9)(10)(11)(12)(13)(14), the arterio-venous extraction (A/V) technique (13,(15)(16)(17)(18)(19), the Rutland-Patlak plot techniques (20,21), the MR gadolinium slope clearance measurement technique (22) and the dynamic MR perfusion functional assessment (23,24). Since the iodinated contrast media and gadolinium contrast media in current use are nearly identical in their pharmacokinetics and renal handling, either CT or MR provide competitive utilization.…”

Section: Reviewmentioning

confidence: 99%

MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: feasibility and preliminary report

Katzberg

Buonocore

Low

et al. 2009

Contrast Media & Molecular

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This study was conducted to demonstrate the feasibility of quantifying single kidney glomerular filtration rate (skGFR) by magnetic resonance (MR) by comparison to the clinical estimates of GFR in volunteer subjects with a single kidney. Seven IRB-approved subjects with a solitary kidney, stable serum creatinine (SCr) and a 24 h creatinine clearance (CrCl) volunteered to undergo an MR examination that determined renal extraction fraction (EF) with a breathhold inversion recovery echo planar pulse sequence and renal blood flow with a velocity encoded phase imaging sequence. The product of EF and blood flow determines GFR. These values were compared with the 24 h CrCl, estimated GFR by the modification of diet in renal disease (MDRD) regression analysis and the Cockroft-Gault (CG) determination of CrCl. The mean and standard deviation of differences between the MR GFR, MDRD and CG vs the 24 h CrCl were 12.3+/-35.7, -8.9+/-18.5 and 1.2+/-19.6, respectively. The Student t-test showed that none of the mean differences were statistically significant between techniques. This clinical investigation shows that MR can be used for skGFR determination in human subjects with comparable values to those derived from clinically used serum-based GFR estimation techniques.

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Glomerular Filtration Rate Measured by Using Triphasic Helical CT with a Two-Point Patlak Plot Technique

Abstract: Total GFR can be measured accurately with minimally extended triphasic CT in patients without acute renal disorder by using a two-point Patlak plot technique.

Cited by 57 publications

References 17 publications

Renal parenchyma thickness: a rapid estimation of renal function on computed tomography

Renal parenchyma thickness: a rapid estimation of renal function on computed tomography

Quantitative and qualitative analysis and interpretation of CT perfusion imaging

MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: feasibility and preliminary report

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