Glomerular Filtration Rate in Children with Advanced Chronic Renal Failure: Methods of Determination and Clinical Applications

Chan, James C.M.; Sharpe, Alton R.

doi:10.1159/000166584

Cited by 10 publications

(1 citation statement)

References 37 publications

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“…Her cre atinine clearance was 19 ml/min/1.73 m2 which is at the lower limit of normal for this age [44], The kidney still suffers from inability to concentrate with specific gravity at 1.004-1.005.…”

Section: Dr James CM Chanmentioning

confidence: 84%

Dehydration, Renal Vein Thrombosis and Hyperkalemic Renal Tubular Acidosis in a Newborn

Glassock¹,

Duffee²,

Kodroff³

et al. 1983

Am J Nephrol

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Section: Dr James CM Chanmentioning

confidence: 84%

Dehydration, Renal Vein Thrombosis and Hyperkalemic Renal Tubular Acidosis in a Newborn

Glassock¹,

Duffee²,

Kodroff³

et al. 1983

Am J Nephrol

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Nutritional management of children with chronic renal failure

et al. 1987

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Current information on the adaptations to progressive loss of renal function is presented. The assessment of renal function in infants and children using serum creatinine concentration and its derivatives is considered as are various methods for assessment of growth. Children with creatinine clearances less than 50% of normal, who do not have uremic symptoms (and who are not on dialysis), should be ingesting diets providing close to 100% of the RDA for calories with 8% of the calories as protein. Recommendations for nutritional management of children on chronic peritoneal dialysis are also presented.

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Vitamin E therapy in IgA nephropathy: a double-blind, placebo-controlled study

Chan

Mahan

Trachtman

et al. 2003

Pediatric Nephrology

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IgA nephropathy is the world's most common primary glomerulonephropathy. Recent evidence in a rat model implicated excessive production of oxygen-free radicals in the pathogenesis and suggested that vitamin E-treatment ameliorated progression. We studied this antioxidant therapy on the glomerular filtration rate (GFR), proteinuria and hematuria in biopsy-proven IgA nephropathy in children. The duration of treatment or placebo was 2 years, with vitamin E treatment consisting of 400 IU/day in children weighing <30 kg, and twice that dose for those >30 kg. We measured GFR at entry, midpoint and exit. At baseline and at 4-month intervals after randomization, urinary protein/creatinine ratios and urinalysis were examined. The mixed model procedure with log transformation was used in data analysis to test treatment difference as well as the potential time effect. Fifty-five patients were randomized and 38 completed at least 1 year of follow-up. At entry, the clinical characteristics were not different between the treatment and placebo groups. There was a trend toward better preservation of GFR in vitamin E-treated versus placebo patients, 127+/-50 vs. 112+/-31 ml/min/1.73 m(2), respectively ( P=0.09). The urinary protein/creatinine ratio was significantly lower in the vitamin E-treated group vs. placebo; 0.24+/-0.38 vs. 0.61+/-1.37 ( P<0.013). However, there was no difference in the prevalence of hematuria between the groups. Vitamin E treatment in our study patients was associated with significantly lower proteinuria, but no effect on hematuria. While there was a trend toward stabilization of GFR in the vitamin E-treated patients, long-term treatment and follow-up are needed to determine whether antioxidant therapy is associated with preservation of renal function in IgA nephropathy.

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Glomerular Filtration Rate in Children with Advanced Chronic Renal Failure: Methods of Determination and Clinical Applications

Cited by 10 publications

References 37 publications

Dehydration, Renal Vein Thrombosis and Hyperkalemic Renal Tubular Acidosis in a Newborn

Dehydration, Renal Vein Thrombosis and Hyperkalemic Renal Tubular Acidosis in a Newborn

Nutritional management of children with chronic renal failure

Vitamin E therapy in IgA nephropathy: a double-blind, placebo-controlled study

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