Glomerular filtration rate estimation based on a single blood sample.

Fisher, M.; Veall, N.

doi:10.1136/bmj.2.5970.542

Cited by 59 publications

(16 citation statements)

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“…Several studies have suggested limited plasma sampling after bolus clearance techniques to make the procedure less cumbersome (27)(28)(29)(30)(31). The scientific rationale offered by these studies is that limited sampling technique and full study are highly correlated, therefore limited sampling technique provides good information.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Iothalamate Plasma Clearance

Agarwal¹,

Bills²,

Yigazu³

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Measurement of GFR is important for the management of chronic kidney disease (CKD).Although bolus administration of radiocontrast agents is commonly used to measure GFR, the optimal duration of sampling to assess their plasma clearance is unknown. The purpose of this study was to evaluate whether the duration of plasma sampling influences precision and estimation of GFR.Design, setting, participants, & measurements: GFR was measured by sampling plasma 12 times over 5 h in 56 patients with CKD (mean age 64 yr, 98% men, 79% Caucasian, 34% diabetics, estimated GFR 31.8 ؎ 14.2 ml/min/1.73 m 2 ). In a subset of 12 patients we measured GFR by sampling plasma 17 times over 10 h.Results: Short sampling intervals considerably overestimated GFR measured using total plasma iothalamate clearance, especially in larger patients. In the higher estimated GFR group (>30 ml/min/1.73m2 ), the 5-h GFR was 17% higher and 2-h GFR 54% higher compared with the 10-h GFR, which averaged 40.3 ml/min/1.73 m 2 . In the lower estimated GFR group (<30 ml/min/1.73m2 ), the 5-h GFR was 36% higher and 2-h GFR 126% higher compared with the 10-h GFR, which averaged 22.2 ml/min/1.73 m 2 . Short sampling duration also reduced the precision of the estimated GFR from 1.67% for 10-h GFR, to 3.48% for 5-h GFR, and to 7.07% for 2-h GFR.Conclusions: GFR measured over a longer duration with multiple plasma samples spanning the distribution and elimination phases may improve precision and provide a better measure of renal function.

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Section: Discussionmentioning

confidence: 99%

Assessment of Iothalamate Plasma Clearance

Agarwal¹,

Bills²,

Yigazu³

et al. 2009

Clinical Journal of the American Society of Nephrology

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“…This simplification introduced systematic errors in the values of GFR obtained and various methods of correction have been derived [4][5][6]. The methodology underwent even further simplification by reducing the number of samples to one [7,8]. Empirical relationships between the apparent volume of distribution and GFR were derived which allow GFR to be estimated from a single sample concentration with reasonable precision [9,10].…”

Section: Introductionmentioning

confidence: 99%

Guidelines for the measurement of glomerular filtration rate using plasma sampling

Fleming¹,

Zivanovic²,

Blake³

et al. 2004

Nuclear Medicine Communications

274

315

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“…On the other hand, when the terminal slope-intercept method is used to minimize the number of blood samples, clearance could be overestimated since the first exponential component is ignored. Most authors (Br6chner-Mortensen 1972; Fisher and Veall 1975;Constable et al 1979;Growth and Aasted 1981;Jacobsson 1983;Christensen and Groth 1986;Tauxe 1986) have developed an empirical evaluation of plasma clearance which necessitates only one or few blood samples.…”

Section: Introductionmentioning

confidence: 99%

Estimation of chromium-51 ethylene diamine tetra-acetic acid plasma clearance: a comparative assessment of simplified techniques

Picciotto¹,

Cacace²,

Cesana

et al. 1992

Eur J Nucl Med

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Chromium-51 ethylene diamine tetra-acetic acid (51Cr-EDTA) total plasma clearance was evaluated using a multi-sample method (i.e. 12 blood samples) as the reference compared with several simplified methods which necessitated only one or few blood samples. The following 5 methods were evaluated: terminal slope-intercept method with 3 blood samples, simplified method of Bröchner-Mortensen and 3 single-sample methods (Constable, Christensen and Groth, Tauxe). Linear regression analysis was performed. Standard error of estimate, bias and imprecision of different methods were evaluated. For 51Cr-EDTA total plasma clearance greater than 30 ml.min-1, the results which most approximated the reference source were obtained by the Christensen and Groth method at a sampling time of 300 min (inaccuracy of 4.9%). For clearances between 10 and 30 ml.min-1, single-sample methods failed to give reliable results. Terminal slope-intercept and Bröchner-Mortensen methods were better, with inaccuracies of 17.7% and 16.9%, respectively. Although sampling times at 180, 240 and 300 min are time-consuming for patients, 51Cr-EDTA total plasma clearance can be accurately calculated for values greater than 10 ml.min-1 using the Bröchner-Mortensen method. In patients with clearance greater than 30 ml.min-1, single-sample techniques provide a good alternative to the multi-sample method; the choice of the method to be used depends on the degree of accuracy required.

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Glomerular filtration rate estimation based on a single blood sample.

Cited by 59 publications

References 1 publication

Assessment of Iothalamate Plasma Clearance

Assessment of Iothalamate Plasma Clearance

Guidelines for the measurement of glomerular filtration rate using plasma sampling

Estimation of chromium-51 ethylene diamine tetra-acetic acid plasma clearance: a comparative assessment of simplified techniques

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