Glomerular filtration rate estimated by X-ray fluorescence technique in children: comparison between the plasma disappearance of 99Tcm-DTPA and iohexol after urography

Stake, G; Monn, E.; Rootwelt, K; Grönberg, T.; Monclair, T.

doi:10.3109/00365519009089148

Cited by 19 publications

(11 citation statements)

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“…The classical reference method for estimation of GFR is the renal clearance of inulin, but this method is not useful in equids routine clinical practice because it requires constant IV infusion, water loading, and bladder catheterization to ensure accurate urine collection [5][6][7] The use of inulin in clinical setting was replaced by radiolabeled compounds [3,4,[8][9][10][11][12][13][14][15][16][17], although particular facilities are required to work with radioactive tracers. Iohexol (IOX) is a nonionic low-osmolarity contrast medium widely used in many species because of its low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Determination of Glomerular Filtration Rate in Adult Horses and Donkeys by Single IV Administration of Iohexol

Meucci¹,

Sgorbini²,

Bonelli³

et al. 2015

Journal of Equine Veterinary Science

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Section: Introductionmentioning

confidence: 99%

Determination of Glomerular Filtration Rate in Adult Horses and Donkeys by Single IV Administration of Iohexol

Meucci¹,

Sgorbini²,

Bonelli³

et al. 2015

Journal of Equine Veterinary Science

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“…168,172 Studies describing the accuracy of the estimate show that approximately 75% of Schwartz formula estimates of GFR are within 30% of the measured GFR by inulin clearance. 124,170,171,[176][177][178][179][180] Comparable studies of the Counahan-Barratt formula show 70% to 86% of Counahan-Barratt estimates fall within 30% of GFR measured by 51 Cr-EDTA.…”

Section: K/doqi National Kidney Foundation Part 5 Evaluationmentioning

confidence: 99%

Evaluation of Renal Function Estimation Formulas Specific to Dynamic Renal Function for Drug Dosing in Critically Ill Patients

Xiong¹,

Lu²,

Quidley³

et al. 2018

Southern Medical Journal

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These guidelines are based upon the best information available at the time of publication. They are designed to provide information and assist decision making. They are not intended to define a standard of care, and should not be construed as doing so. Neither should they be interpreted as prescribing an exclusive course of management.Variations in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every healthcare professional making use of these guidelines is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation.The recommendations for research contained within this document are general and not meant to imply a specific protocol.

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“…Stake et al [36] injected 2 ml/kg body weight of iohexol 350 mg I/ml in children who underwent a routine intravenous urography. In order to examine whether the GFR was affected by the contrast medium, Tc-99m DTPA clearance was estimated both 2 days before and simultaneously with the iohexol study without detecting any change in the GFR after the contrast medium was given.…”

Section: Nonionic Monomeric Contrast Media As Gfr Markersmentioning

confidence: 99%

“…The radiation dose to pregnant women and children can be decreased by using a non-radioactive GFR marker whose concentration in plasma and urine is easy to determine with the aforementioned methods [35,36,37]. 3.…”

Section: Choice Of Gfr Markermentioning

confidence: 99%

Contrast media as markers of GFR

Frennby

Sterner

2001

Eur Radiol

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Determination of the glomerular filtration rate (GFR) is generally considered as the most important parameter of quantifying renal function. The GFR is determined as renal or plasma clearance of an ideal filtration marker which is freely filtered by the kidney, does not undergo metabolism, tubular secretion or absorption. Markers that fulfil these demands are inulin, 51Cr-EDTA, 99mTc-DTPA, labelled or unlabelled contrast media. The renal clearance of inulin is the classic reference method for estimation of the GFR. This method is however not practical for routine clinical purposes. Radionucleids have therefore been used as alternative filtration markers since the 60s. Drawbacks related to radiation exposure especially in children and pregnant women and the safety in handling radiolabelled markers have led to an increasing interest in using non-radioactive markers. The development of simple and reliable methods to determine the concentration of contrast media in plasma and urine, such as high-performance liquid chromatography (HPLC) and X-ray fluorescence analysis have made this possible. The non-ionic low osmolar contrast medium iohexol has become the most commonly used contrast medium for GFR measurements in Europe. However, other contrast media with similar pharmacokinetics may be equally suitable as GFR markers.

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Glomerular filtration rate estimated by X-ray fluorescence technique in children: comparison between the plasma disappearance of 99Tcm-DTPA and iohexol after urography

Cited by 19 publications

References 0 publications

Determination of Glomerular Filtration Rate in Adult Horses and Donkeys by Single IV Administration of Iohexol

Determination of Glomerular Filtration Rate in Adult Horses and Donkeys by Single IV Administration of Iohexol

Evaluation of Renal Function Estimation Formulas Specific to Dynamic Renal Function for Drug Dosing in Critically Ill Patients

Contrast media as markers of GFR

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