Glomerular Filtration Rate and Coronary Artery Disease Burden in Patients with Acute Coronary Syndrome

Nunes, José Pedro L.; Faria, Maria do Sameiro; Garcia, J.M. Mota; Gonçalves, Francisco Rocha

doi:10.1002/clc.20145

Cited by 8 publications

(13 citation statements)

References 27 publications

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“…In the present study eGFR value in CAD patients differed significantly from that of patients with normal coronaries on CAG (80.8 ± 22.9, 91.3 ± 28.9, p < 0.001),CAD patients tend to have low eGFR (Table 2). In a study by Jos'e Pedro L et al [29], a relatively weak but significant negative correlation was found between eGFR and CAD burden on angiography (r = −0.26, p = 0.006), this is in agreement with the observed negative correlation of eGFR with CAD in present study (r = −0.148, p < 0.02) ( Table 3). World Journal of Cardiovascular Diseases Though the strength of correlation is small, the increase in the HbA1c, CIMT values and decrease in the glomerular filtration rate predicted CAD on angiography as explained by Spearman correlation analysis (Table 3).…”

Section: Discussionsupporting

confidence: 92%

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Kapil¹,

Rajasekhar²,

Vanjakshamma³

et al. 2018

WJCD

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Background: Pre-diabetic state, renal function, atherosclerosis burden are the major predictors for development of coronary artery disease (CAD). Present study aims to analyze the role of carotid intima-media thickness (CIMT), glomerular filtration rate (eGFR) and serum glycosylated hemoglobin (HbA1c) levels in predicting CAD on coronary angiography in non-diabetic patients. Methods: CAD and its severity according to SYNTAX score (SX score) was evaluated in 450 non-diabetic patients hospitalized with acute coronary syndrome or stable angina and underwent coronary angiography. CIMT, eGFR, and serum HbA1c values were obtained during admission. Spearman correlation and linear regression were used in the analysis of the data. Receiver operating characteristic (ROC) curve was constructed to calculate cutoff values, area under curve (AUC), sensitivity and specificity. Results: Statistically significant positive correlation was observed between HbA1c (r: 0.242, p = 0.001); CIMT (r: 0.231, p = 0.001), patient's age (r: 0.148, p = 0.002) and SX score, whereas eGFR was negatively correlated (r: −0.148, p = 0.002). On regression analysis, CIMT, eGFR, HbA1c and patient's age collectively predicted 36% of change in the SYNTAX score. Patient's age > 56 years (AUC = 0.622), CIMT > 0.86 mm (AUC = 0.642), HbA1c > 6 (AUC = 0.620), eGFR < 92 ml/min/1.73 m 2 (AUC = 0.601) were the cutoff values on ROC curve analysis.CIMT, HbA1c had relatively high specificity (88.5%, 90.2% respectively) and eGFR had relatively high sensitivity (71.3%) among the studied variables in predicting CAD in present study. Conclusions: CIMT, HbA1c, eGFR and patient's age at the time of admission predict CAD in non-diabetic patients undergoing coronary angiography.

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Section: Discussionsupporting

confidence: 92%

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Kapil¹,

Rajasekhar²,

Vanjakshamma³

et al. 2018

WJCD

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“…In a cohort previously studied, including 110 patients with acute coronary syndrome, relatively weak but significant correlations were seen between CADB and decreased renal function, on the one hand, and plasma calcium, on the other hand [2].…”

Section: Introductionmentioning

confidence: 91%

“…More recently, a decrease in renal function was also noted to be associated to coronary artery disease [2].…”

Section: Introductionmentioning

confidence: 99%

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Systemic Correlates of Angiographic Coronary Artery Disease

Nunes

Silva

2009

PLoS ONE

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Coronary angiography allows a direct evaluation of coronary anatomy. The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters. A group of 116 patients (80 male, 36 female) with coronary heart disease diagnosed by angiography, aged 62.0±10.5 years, was the subject of an observational study. Correlation and linear regression analysis using coronary artery disease burden (CADB - sum of the percentage of the luminal stenosis encountered in all the lesions of the coronary arterial trees) as dependent variable, and age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index as independent variables, were carried out. Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p<0.001). Linear regression analysis, yielding a global significance level of 0.002, showed a significant value for glucose (p 0.018) and for sex (0.008). In conclusion, among several systemic parameters studied, plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.

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“…Coronary artery disease increases in prevalence with lower eGFR and is the leading cause of mortality in patients with CKD . Among patients referred for coronary angiography, those with CKD have a higher prevalence of severe coronary artery disease, often have significant coronary artery lesions amenable to angioplasty, and more frequently have high‐risk coronary anatomy, including left main or 3‐vessel coronary disease, compared to those without CKD . These observations suggest that coronary revascularization has the potential to improve outcomes of patients with CKD, including symptoms of coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

Kidney Function Does Not Modify the Favorable Quality of Life Changes Associated With Revascularization for Coronary Artery Disease: Cohort Study

James

Wilton

Clement

et al. 2016

JAHA

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BackgroundAlthough patients with kidney disease have potential to benefit from revascularization, they are also at higher risk of complications, which may affect quality of life.Methods and ResultsWe studied a cohort of 8198 adults who underwent coronary angiography in Alberta, between 2004 and 2008, and completed health‐related quality‐of‐life (HR‐QOL) surveys. Changes in HR‐QOL measures were most favorable among patients who received coronary artery bypass graft (CABG), but did not significantly differ by kidney function within groups of patients who received CABG, percutaneous coronary intervention (PCI), or medical therapy (P value for interaction between estimated glomerular filtration rate [eGFR] and revascularization status >0.10 for all outcomes). Among those who received CABG, the adjusted mean EuroQol 5 dimensions (EQ‐5D) utility score for those with eGFR >90 mL/min per 1.73 m2 increased by 0.11 (95% CI, 0.09–0.14) and for those with eGFR <30 mL/min per 1.73m2 by 0.13 (95% CI, 0.05–0.21). The adjusted mean EQ‐5D utility score also increased similarly at all levels of eGFR for those who received PCI and for those who received medical management. Mean changes in Seattle Angina Questionnaire (SAQ) scores were also similar across all levels of eGFR within each treatment group for the quality of life, angina frequency, angina stability, physical limitations, and treatment satisfaction domains of the SAQ. Among those who received CABG, the adjusted mean SAQ quality of life score for those with eGFR >90 mL/min per 1.73m2 increased by 22.1 (95% CI, 18.5–25.7) and for those with eGFR <30 mL/min per 1.73m2 by 14.0 (95% CI, 2.31–25.63).ConclusionsChanges in HR‐QOL do not vary by kidney function among patients selected for CABG, PCI, or medical management of coronary disease.

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Glomerular Filtration Rate and Coronary Artery Disease Burden in Patients with Acute Coronary Syndrome

Cited by 8 publications

References 27 publications

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Role of CIMT, eGFR, and Serum HbA1c in Predicting CAD in Non-Diabetic Patients Undergoing Elective Coronary Angiography

Systemic Correlates of Angiographic Coronary Artery Disease

Kidney Function Does Not Modify the Favorable Quality of Life Changes Associated With Revascularization for Coronary Artery Disease: Cohort Study

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