Glomerular Filtration Rate and Albumin Excretion After Maximal Exercise in Aging Sedentary and Active Men

Poortmans, Jacques; Ouchinsky, Michel

doi:10.1093/gerona/61.11.1181

Cited by 33 publications

(35 citation statements)

References 22 publications

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“…The method employs source-induced fragmentation, designed to obviate the need for trypsin digestion and potential issues with incomplete digestion. Similar results were obtained using either 15 N-labeled human serum albumin prepared in a yeast expression system (125 ) or less expensive bovine serum albumin (126 ) as internal standards. Calibration was based on a charcoal-stripped urine supplemented with commercial human serum albumin whose concentration was quantified by the molar absorptivity [38553 L/(molcm)] at 280 nm (127 ).…”

Section: Albuminsupporting

confidence: 70%

Current Issues in Measurement and Reporting of Urinary Albumin Excretion

et al. 2009

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BACKGROUND: Urinary excretion of albumin indicates kidney damage and is recognized as a risk factor for progression of kidney disease and cardiovascular disease. The role of urinary albumin measurements has focused attention on the clinical need for accurate and clearly reported results. The National Kidney Disease Education Program and the IFCC convened a conference to assess the current state of preanalytical, analytical, and postanalytical issues affecting urine albumin measurements and to identify areas needing improvement. CONTENT:The chemistry of albumin in urine is incompletely understood. Current guidelines recommend the use of the albumin/creatinine ratio (ACR) as a surrogate for the error-prone collection of timed urine samples. Although ACR results are affected by patient preparation and time of day of sample collection, neither is standardized. Considerable intermethod differences have been reported for both albumin and creatinine measurement, but trueness is unknown because there are no reference measurement procedures for albumin and no reference materials for either analyte in urine. The recommended reference intervals for the ACR do not take into account the large intergroup differences in creatinine excretion (e.g., related to differences in age, sex, and ethnicity) nor the continuous increase in risk related to albumin excretion. DISCUSSION:Clinical needs have been identified for standardization of (a) urine collection methods, (b) urine albumin and creatinine measurements based on a complete reference system, (c) reporting of test results, and (d) reference intervals for the ACR.

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Section: Albuminsupporting

confidence: 70%

Current Issues in Measurement and Reporting of Urinary Albumin Excretion

et al. 2009

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“…In previous studies, we showed that in healthy subjects strenuous exercise had a major effect on kidney function, namely reducing GFR and enhancing albumin excretion rate 16–19. We emphasised the importance to accurately evaluate GFR in exercising healthy individuals using both Crn serum concentration and urine Crn output,17 from children20 to seniors 16.…”

Section: Introductionmentioning

confidence: 99%

“…We emphasised the importance to accurately evaluate GFR in exercising healthy individuals using both Crn serum concentration and urine Crn output,17 from children20 to seniors 16. Also, we stressed the importance of GFR evaluation in diabetic patients,17 21 heart and kidney transplant recipients22–24 involved in exercise training sessions.…”

Section: Introductionmentioning

confidence: 99%

Limitations of serum values to estimate glomerular filtration rate during exercise

Poortmans¹,

Gulbis

Bruyn

et al. 2012

Br J Sports Med

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“…This induces a decrease in renal blood flow, in accordance with the exercise intensity, and consequently a transitory deterioration in the renal hemodynamic as well as a stimulation of the electrolytes and proteins excretion (Poortmans, 1995). Works on the interaction between exercise and kidney are scarce and most of them were undertaken in developed countries with moderate climate (Lippi, Banfi, Salvagno, Franchini, & Guidi, 2008b;Poortmans & Ouchinsky, 2006). The majority of studies related to renal function, undertaken in Africa and particularly in developing countries, were about the epidemiological aspects of renal affections (Naicker, 2009;Gnionsahe, Lagou, & Tia, 2007).…”

Section: Introductionmentioning

confidence: 99%

Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

Tonon¹,

Agboton²,

Falola³

et al. 2012

APE

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This study aims at assessing the modifications of renal parameters with 13 female players of the same Benin team-amateur Division 1, during two consecutive handball games played 26 hours apart. The players are divided into two groups: starters (ST: N = 7) and nonstarters (NS: N = 6). The estimated glomerular filtration rate (eGFR) with Cockcroft-Gault and MDRD formulas, the fractional excretion of sodium (FeNa), the plasma haemoglobin (Hb) and albumin (Alb) were assayed at rest and at the end of each game. At the end of the first game, only eGFR decreased significantly by at least 16.30% (p < 0.05) in ST only. At the end of the second game, the average reductions of eGFR are significant in both the ST and NS groups (p < 0.05), but they are less important than those recorded at the end of the first (p > 0.05). FeNa varied in no group, neither after the first game, nor after the second (p > 0.05). But a cumulative reduction is observed between the values before the first and those recorded at the end of the second game in both ST and NS groups. The status of the players (ST or NS) did not influence the results. Two games of handball played 26 hours apart in the sub-Saharan environment of Cotonou caused in girls, a transitory decrease in eGFR without a cumulative effect. FeNa decreased too, but with a cumulative effect which indicates large sodium retention.

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Glomerular Filtration Rate and Albumin Excretion After Maximal Exercise in Aging Sedentary and Active Men

Cited by 33 publications

References 22 publications

Current Issues in Measurement and Reporting of Urinary Albumin Excretion

Current Issues in Measurement and Reporting of Urinary Albumin Excretion

Limitations of serum values to estimate glomerular filtration rate during exercise

Renal Responses to a Series of Handball Games Played in Sub-Saharan Environment by Amateur Division 1 of Female Players

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