Glomerular Diseases in Madina Region;

Abstract

Objectives: The study is designed to get useful information and epidemiological data for clinical practice and investigations regarding glomerular disease frequencies in Madina region. Study Design & Setting: Single-center retrospective study at King Fahd Hospital Madina. Period: 01 year (March 2016- March 2017). Methods: All native renal biopsies were studied for the period of 1 year (March 2016- March 2017). Only glomerular disease patterns were analyzed. The diagnosis of each case was based on histological, immunopathological and clinical features. Results: A total of 44 biopsies were Included. Primary glomerular diseases in 52.27% of all biopsies studied. The most common primary disease was Membranous Nephropathy which accounts for 20.45%. Focal and Segmental Glomerulosclerosis (FSGS) (9%), Minimal change disease (4.54%), C3 glomerulopathy (4.54%), IGA Nephropathy (4.54%), Non-IgA Mesangial Proliferative GN(2.27%), Crescentic Glomerulonephritis (GN) (2.27%), Post lnfectlous GN(2.27%), Thin Basement Membrane Nephropathy(2.27%) as primary GN. Secondary glomerular diseases in 47.73%. Lupus Nephritis corresponded to 34.09% of the entire series. Conclusions: FSGS has been the most frequent type of glomerulopathy in Saudi Arabian population according to previously available data from local studies but in our study the cases of Membranous Nephropathy were high .Lupus Nephritis remain above the list as a cause of secondary glomerular disease. The reasons for these findings are unclear but this information is an important contribution towards understanding the prevalence of renal diseases In Saudi Arabia.

Clinicopathologic features, chronic renal damage, and short-term outcomes of glomerular diseases in a middle east tertiary care center

“…This nding is consistent with other studies in Egypt [16,27] and also in Iraq [28] and Oman [29]. This nding is also similar to previous reports in Saudi Arabia [5,30,31], although a recent Saudi study showed that membranous nephropathy (MN) was the most common primary GD [21]. It might be possible that the latter study indicates a changing spectrum of GDs in Saudi Arabia; a notion that awaits con rmation by future research.…”

“…On the other hand, many other published studies showed predominance of primary GDs, whether these studies were carried out in Egypt [15,17] or other countries, e.g. Saudi Arabia [5,21], Taiwan [22] and Bangladesh [23]. The reason for this discrepancy in the frequency of secondary in comparison to primary GDs is not readily explainable; but one possible explanation might reside in misclassi cation of some secondary GDs as primary due to lack of the ability to identify the accompanying disorder.…”

Clinicopathologic Features, Chronic Renal Damage and Short-Term Outcomes of Glomerular Diseases in a Middle East Tertiary Care Center

“…This nding is consistent with other studies in Egypt [16,27] and also in Iraq [28] and Oman [29]. This nding is also similar to previous reports in Saudi Arabia [5,30,31], although a recent Saudi study showed that membranous nephropathy (MN) was the most common primary GD [21]. It might be possible that the latter study indicates a changing spectrum of GDs in Saudi Arabia; a notion that awaits con rmation by future research.…”

“…On the other hand, many other published studies showed predominance of primary GDs, whether these studies were carried out in Egypt [15,17] or other countries, e.g. Saudi Arabia [5,21], Taiwan [22] and Bangladesh [23]. The reason for this discrepancy in the frequency of secondary in comparison to primary GDs is not readily explainable; but one possible explanation might reside in misclassi cation of some secondary GDs as primary due to lack of the ability to identify the accompanying disorder.…”