Glomerular diseases associated with hematopoietic neoplasms: an expanding spectrum

Haas, Mark; VanBeek, Christine

doi:10.1038/ki.2011.176

Cited by 7 publications

(6 citation statements)

References 15 publications

(5 reference statements)

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“…Recently, Said et al (14) reported that MPNrelated glomerulopathy was a late complication of neoplasms with a generally poor renal outcome. Hass et al (15) questioned whether earlier recognition of MPN-related glomerulopathy might have resulted in better renal outcomes, yet evidence from other primary and secondary glomerular diseases suggests that this is not unreasonable. The present case did not exhibit either globally sclerotic glomeruli or moderate/severe tubulointerstitial scarring, which is different from the patients described by Said et al (14).…”

Section: Discussionmentioning

confidence: 99%

“…Hematologic malignancies can lead to glomerular insults, such as matrix/abnormal protein accumulation, proliferative GN/hypercellular glomeruli, and podocytopathy (15). Plasma-cell dyscrasias, podocyte injury caused by neoplastic cells, and released cytokines/permeability factors might be causes of GN, but the exact mechanism is still unclear (16,17).…”

Section: Discussionmentioning

confidence: 99%

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Nephrotic Syndrome Related to Chronic Neutrophilic Leukemia

et al. 2014

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Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm. We herein describe the case of a 41-year-old woman who was admitted with nephrotic syndrome (NS) and severe neutrophilia and underwent a splenectomy due to splenomegaly. Peripheral blood tests revealed a Janus kinase 2 (JAK2) V617F mutation without the Philadelphia chromosome, BCR-ABL fusion transcripts, or FIP1 L1-platelet-derived growth factor (PDGF)a. A kidney biopsy showed focal segmental glomerulosclerosis (FSGS) with interstitial neutrophil infiltration and with a JAK2 V617F mutation. Hydroxyurea was initiated for first three months, followed by hydroxyurea plus interferon, and a subsequent improvement in leukocytosis and completely remission of FSGS-NS was immediately noted. This is the first case reported in which NS was related to CNL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nephrotic Syndrome Related to Chronic Neutrophilic Leukemia

et al. 2014

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“…However, no randomized-controlled study has been performed to evaluate the prevalence of renal alterations. To date, the most well-recognized and well-established associations with glomerular disorders have been in people with hematopoietic cancers [ 19 ] and solid tumor carcinomas [ 8 ]. One group has used a rat model (nude rat F344/NJcl-run) to study cancer related glomerulopathy [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Glomerulopathies in Canine Mammary Carcinoma

et al. 2016

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The incidence and prevalence of paraneoplastic glomerulopathy, especially associated with carcinoma, are a matter of debate and the causal link between cancer and glomerular diseases remains unclear. The aim of this study was to evaluate renal biopsies of selected bitches with spontaneous mammary gland carcinoma. We hypothesized that dogs with mammary carcinomas would show histologic evidence of glomerular pathology. A prospective study was performed in dogs with naturally occurring mammary carcinoma that were undergoing tumor resection and ovariohysterectomy. We evaluated renal biopsies of 32 bitches with spontaneous mammary gland carcinoma and 11 control dogs without mammary gland neoplasia. Samples were obtained from the left kidney and the biopsy material was divided for light microscopy (LM), immunofluorescence (IF) and transmission electron microscopy (TEM). Light microscopy abnormalities were identified in 78.1% of dogs with mammary carcinoma (n = 25) and in none of the dogs in the control group. Focal glomerular mesangial matrix expansion was the most common alteration (n = 15, 60.0%), but mesangial cell proliferation (n = 9, 36.0%) and focal segmental glomerulosclerosis (n = 9, 36.0%), synechiae (n = 7, 28.0%), and globally sclerotic glomeruli (n = 6, 24.0%) were also frequent in dogs with malignancy. Immunofluorescence microscopy revealed strong IgM staining was demonstrated in 64.3% (n = 18) of carcinoma dogs. Transmission electron microscopy from dogs with carcinoma revealed slight changes, the most frequent of which was faint sub-endothelial and mesangial deposits of electron-dense material (78%). Mesangial cell interpositioning and segmental effacement of podocyte foot processes were identified in some specimens (45%). Changes in the glomerulus and proteinuria are common in dogs with naturally occurring mammary carcinoma and this condition appears to provide an excellent large animal model for cancer-associated glomerulopathy in humans.

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“…Rarely, immunotactoid glomerulopathy, cryoglobulinemic MPGN, amyloidosis, monoclonal immunoglobulin deposit disease and necrotizing pauci-immune crescentic glomerulonephritis have been described. [ 3 15 19 20 21 22 23 ] Autoimmune mechanisms and T-lymphocyte dysfunction are implicated in the pathogenesis. [ 20 ] In 5 patients of our series with NP range proteinuria, 3 had MPGN, 1 had FSGS and another 1 had DN.…”

Section: Discussionmentioning

confidence: 99%

“…Paraneoplastic glomerulopathies are increasingly recognized. [ 2 3 ] Most cases with renal function derangement respond to effective treatment of underlying neoplasm. The aim of this study was to compile clinical and histologic lesion of underlying malignancies, indication for biopsy, and characteristics of nephropathies.…”

Section: Introductionmentioning

confidence: 99%

Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases

et al. 2015

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Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of “native” renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.

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Glomerular diseases associated with hematopoietic neoplasms: an expanding spectrum

Cited by 7 publications

References 15 publications

Nephrotic Syndrome Related to Chronic Neutrophilic Leukemia

Nephrotic Syndrome Related to Chronic Neutrophilic Leukemia

Prevalence of Glomerulopathies in Canine Mammary Carcinoma

Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases

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