Glomerular deposition of tumor antigen in membranous nephropathy associated with colonic carcinoma

Couser, William G.; Wagonfeld, James B.; Spargo, Benjamin H.; Lewis, Edmund J.

doi:10.1016/0002-9343(74)90176-4

Cited by 136 publications

(53 citation statements)

References 31 publications

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“…However, remission of NS is not always achieved despite an uneventful course of antineoplastic therapy [3,6], as in our patient. Thus, rather than always treating the malignant tumor first when both of these conditions are present, full consideration should also be given to the need for corticosteroids to treat secondary MN.…”

Section: Discussioncontrasting

confidence: 48%

Response of paraneoplastic nephrotic syndrome to corticosteroids combined with chemotherapy for advanced lung cancer: a case report and literature review

et al. 2012

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Paraneoplastic nephrotic syndrome is a rare manifestation associated with various malignancies, the most common of which is lung cancer. In practice, no reports have yet supported the notion that corticosteroids combined with cancer therapy for the syndrome would confer a benefit. We describe a female patient in whom advanced lung cancer associated with membranous nephropathy reached partial remission under chemotherapy, whereas proteinuria in the nephrotic range did not improve. Subsequently the patient was started on corticosteroids, which abolished the proteinuria and improved her performance status. The clinical course suggested that eliminating urinary protein using antineoplastic therapy alone in patients with advanced lung cancer for whom treatment such as chemotherapy was indicated and little could be expected from curative resection tended to be difficult. Therefore, we recommend treating advanced lung cancer and nephrotic syndrome with corticosteroids as well as anticancer agents.

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Section: Discussioncontrasting

confidence: 48%

Response of paraneoplastic nephrotic syndrome to corticosteroids combined with chemotherapy for advanced lung cancer: a case report and literature review

et al. 2012

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“…Dis Chest 56: [19][20][21][22][23]1969 29. Rutherford RB, Rhodes BA, Wagner NH: The distribution of extremity blood flow before and after vagectomy in a patient with hypertrophic pulmonary osteoarthropathy.…”

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confidence: 99%

Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma. A clinical and pathologic study

Schumacher

1976

Arthritis & Rheumatism

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Eight patients with bronchogenic carcinoma presented with painful joint effusions as part of the syndrome of hypertrophic osteoarthropathy. Elevated sedimentation rates and symptomatic relief with aspirin were common, but synovial fluids all had leukocyte counts less than 500/mm3. Synovial microvascular injury was found in all patients, and electron-dense deposits in synovial vessel walls were identified in 5 cases. These vascular deposits suggest a role for circulating materials in pathogenesis.Painful swelling around knees, ankles, wrists, and occasionally fingers may be the presenting manifestation of hypertrophic pulmonary osteoarthropathy (HPO) but can easily be mistaken clinically for rheumatoid arthritis (1,2). Clubbing may be subtle but is rarely absent. Because HPO may be an important early clue to the diagnosis of bronchogenic carcinoma and other pulmonary mass lesions, this report describes 8 cases and emphasizes some characteristics of the arthropathy that should help raise the possibility of a diagnosis of HPO. ~_ _ _ _From the Veterans Administration Hospital and the University of Pennsylvania.

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“…Antígenos tumorales como el antígeno carcinoembrionario, antígeno prostático específico y antígenos de melanoma se han encontrado en asociación a GPNP, sin embargo, su rol causal no se ha demostrado 13 . Excepcionalmente se han recuperado antígenos tumorales en los depósitos existentes en los glomérulos 9,20 . Se ha postulado que el depósito de las diferentes subclases de IgG en la membrana basal glomerular es diferente en las NM idiopáticas respecto a las NM PNP y que ello pudiera orientar en la sospecha de la existencia de un cáncer asociado al SN 21 .…”

Section: Discussionunclassified

Remisión completa de síndrome nefrótico asociado a carcinoma cervicouterino luego de tratamiento del tumor: Comunicación de 2 casos

2012

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Glomerular deposition of tumor antigen in membranous nephropathy associated with colonic carcinoma

Cited by 136 publications

References 31 publications

Response of paraneoplastic nephrotic syndrome to corticosteroids combined with chemotherapy for advanced lung cancer: a case report and literature review

Response of paraneoplastic nephrotic syndrome to corticosteroids combined with chemotherapy for advanced lung cancer: a case report and literature review

Articular manifestations of hypertrophic pulmonary osteoarthropathy in bronchogenic carcinoma. A clinical and pathologic study

Remisión completa de síndrome nefrótico asociado a carcinoma cervicouterino luego de tratamiento del tumor: Comunicación de 2 casos

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