Glomangiopericytoma causing oncogenic osteomalacia

Abstract

A 47-year-old woman suffered from gait disturbance due to back pain and muscle weakness. Laboratory data showed serum hypophosphatemia, elevated alkaline phosphatase, and a normal level of ionized calcium. Radiological examinations revealed multiple pathologic fractures in the ribs and pubic rami. She had had no episode of familial or any other notable disorder, and so she was initially treated with medication for adult-onset osteomalacia. However, 19 years later (when she was 66 years old), she noticed a soft-tissue tumor in her buttock. The tumor was excised. The histological features were those of glomangiopericytoma characterized by both glomus tumor-like and hemangiopericytoma-like structures. After removal of the tumor, her symptoms disappeared immediately. Laboratory data normalized 8 months later. To our knowledge, this is the first report of oncogenic osteomalacia caused by glomangiopericytoma.

Spontaneous deep vein thrombosis of the upper arm due to an intravascular myopericytoma: A case report and literature review

“…[11] Myopericytomas are closely related to myofibromas, glomus tumors, and angioleiomyomas; however, their distinctive feature is the presence of perivascular, concentric, multi-layered, oval-to-spindle cells. [1] Most of these tumors are benign [12,13] ; however, multiple malignant tumors may develop and have been found to be related to the acquired immunodeficiency syndrome. [14,15] The main limitation of the present case report is that it does not present any unique laboratory values; however, it has described a case involving spontaneous deep vein thrombosis, a previously unreported clinical feature of intravascular myopericytomas.…”

“…[ 11 ] Myopericytomas are closely related to myofibromas, glomus tumors, and angioleiomyomas; however, their distinctive feature is the presence of perivascular, concentric, multi-layered, oval-to-spindle cells. [ 1 ] Most of these tumors are benign [ 12 , 13 ] ; however, multiple malignant tumors may develop and have been found to be related to the acquired immunodeficiency syndrome. [ 14 , 15 ]…”

Sinonasal Glomangiopericytoma Causing Oncogenic Osteomalacia

“…Among the causes listed, hypophosphatemia, normal or slightly low serum calcium, normal PTH, elevated alkaline phosphatase, normal 25-hydroxyvitamin D3 and low 1,25-dihydroxyvitamin D3 levels are the usual characteristics of oncogenic osteomalacia. These biochemical abnormalities are normalized by tumor removal [3]. …”