Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

Spinks, Ruth; Nopoulos, Peg; Ward, Julie; Fuller, Rebecca; Magnotta, Vincent A.; Andreasen, Nancy C.

doi:10.1016/j.schres.2004.05.020

Cited by 36 publications

(25 citation statements)

References 18 publications

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“…These correlations persisted even after accounting for antipsychotic dose, duration of treatment, age, age at onset, and duration of illness. A later study of neuroleptic-naïve SCZ patients found a negative correlation between global symptom severity and globus pallidus volume but did not find a significant correlation between severity of specific psychotic symptom domains (i.e., positive, negative, and disorganized) and globus pallidus volume (Spinks et al, 2005). Other basal ganglia structures, including the caudate, were not examined in the study.…”

Section: Discussionmentioning

confidence: 93%

Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder

Womer

Wang

Alpert

et al. 2014

Psychiatry Research: Neuroimaging

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In this study, we examined the morphology of the basal ganglia and thalamus in bipolar disorder (BP), schizophrenia-spectrum disorders (SCZ-S), and healthy controls (HC) with particular interest in differences related to the absence or presence of psychosis. Volumetric and shape analyses of the basal ganglia and thalamus were performed in 33 BP individuals [12 without history of psychotic features (NPBP) and 21 with history of psychotic features (PBP)], 32 SCZ-S individuals [28 with SCZ and 4 with schizoaffective disorder], and 27 HC using FreeSurfer-initiated large deformation diffeomorphic metric mapping. Significant volume differences were found in the caudate and globus pallidus, with volumes smallest in the NPBP group. Shape abnormalities showing inward deformation of superior regions of the caudate were observed in BP (and especially in NPBP) compared with HC. Shape differences were also found in the globus pallidus and putamen when comparing the BP and SCZ-S groups. No significant differences were seen in the nucleus accumbens and thalamus. In summary, structural abnormalities in the caudate and globus pallidus are present in BP and SCZ-S. Differences were more apparent in the NPBP subgroup. The findings herein highlight the potential importance of separately examining BP subgroups in neuroimaging studies.

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Section: Discussionmentioning

confidence: 93%

Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder

Womer

Wang

Alpert

et al. 2014

Psychiatry Research: Neuroimaging

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“…Finally, all five studies examining the globus pallidus failed to detect size differences in this region as compared to healthy controls [23,[25][26][27]31]. Spinks et al found a negative correlation between global symptom severity and the volume of the external segment of the pallidum.…”

Section: Studies On 1st Episode Patientsmentioning

confidence: 98%

Strukturelles Neuroimaging der Basalganglien bei Schizophrenie: ein Review

Brandt

Bonelli

2008

Wien Med Wochenschr

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The basal ganglia structures have quickened interests in schizophrenia research for several reasons: On the one hand, schizophrenic patients are successfully treated with neuroleptics acting on dopamine receptors, which are highly concentrated in the basal ganglia structures. On the other hand, basal ganglia play an important role in higher cognitive functions such as attention, working memory and goal-directed behavior, which are impaired in schizophrenia. Magnetic resonance imaging allows non-invasive in vivo volumetric measurement of these brain structures. In this review, we studied all available papers on MRI research of the basal ganglia in schizophrenic patients. We found a possibly decreased caudate volume in first-episode schizophrenic patients, whereas studies on chronic patients mostly reveal volume increases in caudate, putamen and pallidum. Data from longitudinal studies suggest on the one hand that typical and atypical neuroleptics may produce different effects on brain morphology and on the other hand, that these changes are dynamic and might be reversible. Further studies are warranted for a better understanding of the mechanisms, which may lead to structural basal ganglia abnormalities, with medication effects demanding particular attention.

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“…Functional striatal subcompartments, including sensorimotor striatum (SMST), associative striatum (AST), and limbic striatum (LST) were automatically segmented (Rusjan et al, 2006a) bilaterally as per the method described in (Martinez et al, 2003a). The globus pallidus (GP) delineation procedure used in this study was described elsewhere (Rusjan et al, 2006b); briefly, this method, which creates a probability map of gray matter voxels within the GP (in normal space), models on the procedural steps described in the study by Rusjan et al (2006a) with the exception that the segmentation algorithm (SPM2) focuses on classifying tissues in an area limited to GP, striatum and the surrounding white matter and uses the known volume of GP (3.7 cc; (Spinks et al, 2005)) as the targeted final volume of interest. Midbrain gray matter voxels within the substantia nigra (SN) region were identified using the automated procedure described in (Rusjan et al, 2006a).…”

Section: Roi Analysismentioning

confidence: 99%

Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans

Foll

Guranda

Wilson

et al. 2013

Neuropsychopharmacol

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Positron emission tomography (PET) has convincingly provided in vivo evidence that psychoactive drugs increase dopamine (DA) levels in human brain, a feature thought critical to their reinforcing properties. Some controversy still exists concerning the role of DA in reinforcing smoking behavior and no study has explored whether smoking increases DA concentrations at the D3 receptor, speculated to have a role in nicotine's addictive potential. Here, we used PET and]oxazin-9-ol) to test the hypothesis that smoking increases DA release (decreases [ 11 C]-( þ )-PHNO binding) in D2-rich striatum and D3-rich extra-striatal regions and is related to craving, withdrawal and smoking behavior. Ten participants underwent [ 11 C]-( þ )-PHNO scans after overnight abstinence and after smoking a cigarette. Motivation to smoke (smoking topography), mood, and craving were recorded. Smoking significantly decreased self-reported craving, withdrawal, and [ 11 C]-( þ )-PHNO binding in D2 and D3-rich areas ( À 12.0 and À 15.3%, respectively). We found that motivation to smoke (puff rate) predicted magnitude of DA release in limbic striatum, and the latter was correlated with decreased craving and withdrawal symptoms. This is the first report suggesting that, in humans, DA release is increased in D3-rich areas in response to smoking. Results also support the preferential involvement of the limbic striatum in motivation to smoke, anticipation of pleasure from cigarettes and relief of withdrawal symptoms. We propose that due to the robust effect of smoking on [ 11 C]-( þ )-PHNO binding, this radiotracer represents an ideal translational tool to investigate novel therapeutic strategies targeting DA transmission.

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Globus pallidus volume is related to symptom severity in neuroleptic naive patients with schizophrenia

Cited by 36 publications

References 18 publications

Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder

Basal ganglia and thalamic morphology in schizophrenia and bipolar disorder

Strukturelles Neuroimaging der Basalganglien bei Schizophrenie: ein Review

Elevation of Dopamine Induced by Cigarette Smoking: Novel Insights from a [11C]-(+)-PHNO PET Study in Humans

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