Globus pallidus plays a critical role in neurotrophic factor induced functional improvements in hemiparkinsonian monkeys

Xin, Tao; Ai, Yi; Gerhardt, Greg A.; Gash, Don M.; Zhang, Zhiming

doi:10.1016/j.bbrc.2008.03.108

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…In the past two decades, our group has extensively used rhesus monkeys for neuroimaging studies (Chen et al, 1999; Andersen et al, 2002; Hardy et al, 2005; Zhang et al 2000a, 2001a, 2006, Luan et al, 2008); biology of aging studies (Andersen et al, 1999; Zhang et al, 2000b; Gerhardt et al, 2002; Maswood et al, 2002; Grondin et al, 2003; Ai et al, 2003; Cass et al, 2007); and Parkinson’s disease related research (Gash et al, 1996; Miyoshi et al, 1997; Zhang et al, 1997, 1999; Gerhardt et al, 1999; Grondin et al, 2002, 2008; Maswood et al, 2004; Xin et al, 2008; Ding et al, 2008). Thus, we have accumulated extensive experience in conducting translational research using nonhuman primates under both anesthetized and awake conditions.…”

Section: Introductionmentioning

confidence: 99%

Improved methods for electroacupuncture and electromyographic recordings in normal and parkinsonian rhesus monkeys

Zhao

Fan

Grondin

et al. 2010

Journal of Neuroscience Methods

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Although acupuncture has been widely and routinely used in healthcare in the USA, its use has been based more on empirical observation than on scientific knowledge. Therefore, there is a great need for better understanding the underlying mechanism(s) of action. A great body of evidence supports that nonhuman primates are a candidate for studying human diseases. However, the use of nonhuman primates in neurophysiological, neuroimaging and neurochemical studies is extremely challenging, especially under fully conscious, alert conditions. In the present study, we developed a protocol for safely performing acupuncture, electro-acupuncture (EA) and electromyography (EMG) in both normal nonhuman primates and animals with parkinsonian-like symptoms. Four normal and four hemiparkinsonian middle-aged rhesus monkeys were extensively trained, behaviorally monitored, and received both EA and EMG for several months. The results demonstrated that (1) all rhesus monkeys used in the study could be trained for procedures including EA and EMG; (2) all animals tolerated the procedures involving needle/electrode insertion; (3) EA procedures used in the study did not adversely alter the animal’s locomotor activities; rather, MPTP-treated animals showed a significant improvement in movement speed; and (4) EMG detected significant differences in muscle activity between the arms with and without MPTP-induced rigidity. Our results support that rhesus monkeys can be used as an experimental animal model to study EA and that EMG has the potential to be used to objectively assess the effects of antiparkinsonian therapies. The results also indicate that animals, especially those with parkinsonian-like symptoms, could benefit from long-term EA stimulations.

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Section: Introductionmentioning

confidence: 99%

Improved methods for electroacupuncture and electromyographic recordings in normal and parkinsonian rhesus monkeys

Zhao

Fan

Grondin

et al. 2010

Journal of Neuroscience Methods

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“…Automated Movement Tracking. The detailed procedures have been described elsewhere (Ding et al, 2008; Luan et al, 2008; Walton et al, 2006; Xin et al, 2008). Briefly, video recording procedures were conducted in specially-designed cages located in a room adjacent to the housing quarters.…”

Section: Methodsmentioning

confidence: 99%

Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques

Quintero

Andersen

et al. 2019

NeuroImage: Clinical

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Identification of Parkinson's disease at the earliest possible stage of the disease may provide the best opportunity for the use of disease modifying treatments. However, diagnosing the disease during the pre-symptomatic period remains an unmet goal. To that end, we used pharmacological MRI (phMRI) to assess the function of the cortico-basal ganglia circuit in a non-human primate model of dopamine deficiency to determine the possible relationships between phMRI signals with behavioral, neurochemical, and histological measurements. Animals with unilateral treatments with the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), that expressed stable, long-term hemiparkinsonism were challenged with the dopaminergic receptor agonist, apomorphine, and structure-specific phMRI blood oxygen level-dependent (BOLD) activation responses were measured. Behavioral, histopathological, and neurochemical measurements were obtained and correlated with phMRI activation of structures of the cortico-basal ganglia system. Greater phMRI activations in the basal ganglia and cortex were associated with slower movement speed, decreased daytime activity, or more pronounced parkinsonian features. Animals showed decreased stimulus-evoked dopamine release in the putamen and substantia nigra pars compacta and lower basal glutamate levels in the motor cortex on the MPTP-lesioned hemisphere compared to the contralateral hemisphere. The altered neurochemistry was significantly correlated with phMRI signals in the motor cortex and putamen. Finally, greater phMRI activations in the caudate nucleus correlated with fewer tyrosine hydroxylase-positive (TH + ) nigral cells and decreased TH + fiber density in the putamen. These results reveal the correlation of phMRI signals with the severity of the motor deficits and pathophysiological changes in the cortico-basal ganglia circuit.

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“…Similar surgical procedures have been recently described elsewhere (Xin et al, 2008). Briefly, the animal was positioned in a MRI-compatible stereotaxic head-frame under general anesthesia induced by Ketamine (150 mg/per animal, i.m.)…”

Section: Methodsmentioning

confidence: 99%

Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype

Stephens

Pomerleau

Huettl

et al. 2010

Journal of Neuroscience Methods

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Commonly used for research studies in the central nervous system, microdialysis has revealed a link between dysregulation of the excitatory neurotransmitter glutamate and ischemia and seizure, however limitations like slow temporal resolution have stalled the advancement of microdialysis as a diagnostic tool. We have developed and extensively characterized an enzyme-based microelectrode array technology for second-by-second in vivo amperometric measurements of glutamate in the mammalian CNS. The current studies demonstrated the ability of a human microelectrode array prototype (SG-2) to measure tonic and phasic glutamate neurotransmission in the putamen of unanesthetized non-human primates. We also showed that the SG-2 remains functional following sterilization. Ability to monitor dynamic changes in glutamate in real-time may assist in the development of clinical algorithms to potentially alert care-providers prior to onset of overt ischemia or seizure, or provide neurosurgeons with real-time measurements of rapid changes in extracellular glutamate which could help guide surgical procedures or aid in interventional strategies.

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Globus pallidus plays a critical role in neurotrophic factor induced functional improvements in hemiparkinsonian monkeys

Cited by 3 publications

References 25 publications

Improved methods for electroacupuncture and electromyographic recordings in normal and parkinsonian rhesus monkeys

Improved methods for electroacupuncture and electromyographic recordings in normal and parkinsonian rhesus monkeys

Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques

Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype

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