Objectives: From the beginning of the COVID-19 pandemic, clinical practice and research, globally, have centered on the prevention of transmission and treatment of the disease. The pandemic has had a huge impact on the economy and stressed the health care systems worldwide. The present study estimates Disability-Adjusted Life Years (DALYs), Years of Potential Productive Life Lost (YPPLL), and Cost of Productivity Lost (CPL) due to premature mortality and absenteeism, secondary to COVID-19 in Kerala state, India. Setting: Details on sociodemography, incidence, death, quarantine, recovery time, etc were derived from public sources and CODD-K for Kerala. The working proportion for 5-year age-gender cohorts and corresponding life expectancy were obtained from the Census of India 2011. Primary and secondary outcome measures: The impact of disease on various age-gender cohorts have been analyzed. Sensitivity Analysis has been conducted by adjusting six variables across 21 scenarios. In addition, the estimates have been updated till June 10, 2021. Results: Severity of infection and mortality were higher among the older cohorts, with males being more susceptible than females in most sub-groups. The DALYs for males and females were 15954.5 and 8638.4 till November 15, 2020, and 83853.0 and 56628.3 till June 10, 2021. The corresponding YPPLL were 1323.57 and 612.31 till November 15, 2020, and 6993.04 and 3811.57 till June 10, 2021. CPL (premature mortality) for males and females were 263780579.94 and 41836001.82 till November 15, 2020, and 1419557903.76 and 278275495.29 till June 10, 2021. Conclusions: Most of the COVID-19 disease burden was contributed by YLL. Losses due to YPPLL were reduced as the impact of COVID-19 infection was relatively lesser among productive cohorts. CPL values for 40-49 year-olds were the highest. . These estimates provide the figures and data necessary to policymakers to work on, in order to reduce the economic burden of COVID-19 in Kerala.