Globalisierung konkret: Puma als Fallbeispiel - sachliche und didaktische Vorüberlegungen zu einer Unterrichtseinheit

Evaluation of different vascular access ways in an extracorporeal circulation model for quantitative determination of dual PET/MRI arterial input functions in mice

“…Ziel/Aim Image-derived measurements of the dynamic arterial blood concentration (arterial input function, AIF) for pharmacokinetic modeling (PKM) are challenging for both PET and MRI in mice. Alternatively, an extracorporeal circulation approach can be used 1 . We evaluated the quantitative precision of extracorporeally measured AIFs of MRI contrast agent (CA) and its radioactive analog by dual recordings and compared dispersion effects in two different vascular access ways.…”