In this paper, we investigate the Cauchy problem of the nonlinear wave equation @ 2 t u C u D V.u/u, .t, x/ 2 R R n , where V.u/ D j j juj 2 , 2 R n f0g, 0 < < min.4, n/ and n 3. We prove small data global well-posedness for the radial data and for the general data with angular regularity. We also give an improved result of the Hartree equation with negative critical regularity.The well-posedness theory for the wave equation with Hartree-type nonlinearity was first studied by Menzala and Strauss [3]. They proved the local well-posedness for the H 1 .R n / L 2 .R n / solution of (HNLW) when 0 < < 3 for n D 3 and 0 < Ä 3 for n 4. Mochizuki [4] showed by using the mixed norm estimates of Pecher that the small P H 1 .R n / L 2 .R n / solution of (HNLW) with D 4 < n scatters. Later, Mochizuki and Motai [5] extended the range of to 2 C 2 3.n 1/ < < n. In [6], Hidano proved that small data scattering holds for > 2 in some weighted space of P H 1 .R n / L 2 .R n / when n 3. In this paper, we shall establish the small data global well-posedness for (HNLW) in P H s c P H s c 1 with 0 < s c < 1. More precisely, the main result is the following. 99-112Thus, there exists a unique solution to (HNLW). This completes the proof of Theorem 1(b).