Global uptake of fertility preservation by women undergoing cancer treatment: An unmet need in low to high-income countries

Ojo, A. O.; Lipscombe, Christina; Araoye, Mojisola O.; Akinyemi, Oluwasegun

doi:10.1016/j.canep.2022.102189

Cited by 6 publications

(13 citation statements)

References 62 publications

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“…Comprehensive fertility counselling and optimal care should be provided by a multidisciplinary team of health providers, including 'oncologists, reproductive endocrinologists, mental health counsellors and clinical researchers' [24]. Addressing the need for fertility preservation requires a close and strong collaborative effort of all relevant stakeholders [3,19,20,[24][25][26][27].…”

Section: Discussionmentioning

confidence: 99%

“…In the context of onco-fertility, the provision of information should be combined with 'appropriate and effective fertility-related' psychological support (fertility counselling) [27]. Nevertheless, onco-fertility counselling is 'under-utilized' for female patients for various reasons [3,11,25,29,[33][34][35]. Indeed, 'only a small part of young cancer patients received fertility preservation services' [11].…”

Section: Discussionmentioning

confidence: 99%

“…A retrospective study has shown that 'of all the 918 surveyed cancer survivors who had potential reproductively toxic cancer treatments, 61% of them were counseled by an oncologist about their infertility risk, but only 5% of them visited a fertility specialist and 4% of them ultimately chose to preserve their fertility' [3]. Ojo et al state that in a study… 'half of the young women with cancer in a study received no information from oncologic health care providers about their cancer diagnosis and fertility, and many more received no referral for fertility preservation services' for a variety of reasons [25].…”

Section: Discussionmentioning

confidence: 99%

“…In this study, data analysis implicates physicians' lack of knowledge about cancer-related fertility preservation. Health providers should be updated and prepared to discuss fertility preservation options with their female patients facing a new cancer diagnosis and/or to refer them properly as soon as possible [22,25,34]. 'The level of knowledge of fertility preservation by oncology care providers has a signi cant impact on patient education and the subsequent choices they make' [25].…”

Section: Discussionmentioning

confidence: 99%

“…'Embryo cryopreservation has slightly higher success than oocyte cryopreservation in achieving pregnancy' [42]. Embryo cryopreservation is considered 'the most widely available option', which requires the existence of a partner or the woman's openness to sperm donation [25,30]. While embryo cryopreservation is a long-established and preferred fertility preservation option, the fact that the embryos would be the joint property of the couple can give rise to di cult questions such as who gets the frozen embryo if the relationship ends [19,30].…”

Section: Discussionmentioning

confidence: 99%

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Perceptions and experiences of fertility preservation in Greek female cancer patients

Taniskidou

Voultsos

Tarlatzis

et al. 2023

Preprint

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Background As advances in oncology have led to remarkable and steady improvements in the survival rates of cancer patients and anticancer treatment can cause premature ovarian failure in women, fertility preservation has become a global public health concern and an integral part of the care for women diagnosed with cancer during reproductive age. However, for various reasons, fertility preservation remains underutilized for cancer patients. There are substantial gaps in our knowledge about women’s experience and perceptions on the issue. This study aims to contribute to bridging that gap. Methods This prospective qualitative study was conducted from March 2018 to February 2023. A combination of purposive and snowball sampling was used. Data were collected by semi-structured interviews with nineteen reproductive-age women with a recent cancer diagnosis. Data were classified and analyzed by a thematic analysis approach. Results A variety of distinct themes and subthemes emerged from the analysis of the interview data. The cancer diagnosis emerged as a factor that considerably affects the women’s attitudes towards biological parenthood: It can further increase their (strong) previous desire or decrease their previous (weak) desire. Women with a recent cancer diagnosis did not receive adequate and multidisciplinary counselling, including clear and sufficient information. However, participants felt satisfied from the information they received because they either received the information they requested or remained in denial to get informed (i.e. because they felt overwhelmed after the cancer diagnosis). Embryo cryopreservation emerged as a less desirable fertility preservation option for women with cancer. Participants showed respect for human embryos, not always for religious reasons. Surrogacy emerged as the last resort for most participants. Religious, social or financial factors did play a secondary (if any) role in women’s decision making about fertility preservation. Finally, male partners’ opinions played a secondary role in most participants’ decision-making about fertility preservation. If embryo cryopreservation was the selected option, partners would have a say because they were involved with their genetic material. Conclusions The findings that emerged from data analysis were partly consistent with prior literature. However, we identified some interesting nuances that are of clinical importance. The results of this study may serve as a starting point for future research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Perceptions and experiences of fertility preservation in Greek female cancer patients

Taniskidou

Voultsos

Tarlatzis

et al. 2023

Preprint

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Behavior, attitude, perception, and knowledge regarding fertility preservation among Chinese pediatric oncologists: a survey in China

Shan,

Xu,

Cai

et al. 2024

J Assist Reprod Genet

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Distinct characteristics of the DNA damage response in mammalian oocytes

Leem,

Lee,

Choi

et al. 2024

Exp Mol Med

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DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary for extended periods, are particularly susceptible to DNA damage. The occurrence of DNA damage in oocytes can result in genetic abnormalities, potentially leading to infertility, birth defects, and even abortion. Therefore, understanding how oocytes detect and repair DNA damage is of paramount importance in maintaining oocyte quality and preserving fertility. Although the fundamental concept of the DDR is conserved across various cell types, an emerging body of evidence reveals striking distinctions in the DDR between mammalian oocytes and somatic cells. In this review, we highlight the distinctive characteristics of the DDR in oocytes and discuss the clinical implications of DNA damage in oocytes.

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Global uptake of fertility preservation by women undergoing cancer treatment: An unmet need in low to high-income countries

Cited by 6 publications

References 62 publications

Perceptions and experiences of fertility preservation in Greek female cancer patients

Perceptions and experiences of fertility preservation in Greek female cancer patients

Behavior, attitude, perception, and knowledge regarding fertility preservation among Chinese pediatric oncologists: a survey in China

Distinct characteristics of the DNA damage response in mammalian oocytes

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