Global updates in the treatment of gastric cancer: a systematic review. Part 2: perioperative management, multimodal therapies, new technologies, standardization of the surgical treatment and educational aspects

D’Ugo, Domenico; Agnes, Annamaria; Grieco, Michele; Biondi, Alberto; Persiani, Roberto

doi:10.1007/s13304-020-00771-0

Cited by 20 publications

(13 citation statements)

References 152 publications

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“…Generally, most GC patients were diagnosed at the advanced stage due to the nonspecific symptoms in the early stage of GC, resulting in that this disease was often not diagnosed or ignored [ 4 , 5 ]. Despite advances in treatment over the past few decades, the prognosis for the patients with GC remains poor, with a 5-year survival rate of less than 25% [ 6 , 7 ]. Cisplatin (DDP) is one of the effective chemotherapeutic agents and well known in first-line cancer treatment for various cancers, including GC [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of LINC01857 Increases Sensitivity of Gastric Carcinoma Cells to Cisplatin

Chen

2022

Computational and Mathematical Methods in Medicine

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Background. The critical roles of long noncoding RNAs (lncRNAs) in the carcinogenesis and progression of cancers have been well documented. It was reported that lncRNAs were involved in chemotherapy resistance in various cancers. This study was aimed at clarifying the role of LINC01857 in cisplatin (DDP) resistance in gastric carcinoma (GC). Methods. The Cancer Genome Atlas (TCGA) database was used to analyze the expression of LINC01857 in GC tissues and normal tissues. The expression of LINC01857 in GC cells and DDP-resistant GC cells was detected by qRT-PCR. Cell viability and IC50 value were evaluated using the MTT assay. Moreover, cell apoptosis, migration, and invasion were determined using flow cytometry and Transwell assays, respectively. The expression of apoptosis-related proteins was examined by western blot. Results. TCGA database analysis revealed that LINC01857 expression was elevated in GC tissues compared with the normal tissues. qRT-PCR showed that the expression of LINC01857 was significantly higher in DDP-resistant cells than in GC and normal gastric cells. Knockdown of LINC01857 reduced cell viability in DDP-resistant cells. Moreover, LINC01857 downregulation promoted cell apoptosis and inhibited cell migration and invasion in DDP-resistant GC cells. Conclusions. LINC01857 was highly expressed in GC. Additionally, LINC01857 knockdown could facilitate the sensitivity to DDP and apoptosis and repressed cell migration and invasion in DDP-resistant GC cells, which provided a novel therapeutic target for chemotherapy resistance of GC in clinical practice.

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Section: Introductionmentioning

confidence: 99%

Downregulation of LINC01857 Increases Sensitivity of Gastric Carcinoma Cells to Cisplatin

Chen

2022

Computational and Mathematical Methods in Medicine

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“…The extent of lymphadenectomy is the only factor that can be influenced by the surgeon[ 33 - 38 ]. The total number of lymph nodes resected, or the total number of positive to negative ratio of lymph nodes have all been found to be predictors of survival in gastric cancer patients[ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Postoperative mortality and morbidity after D2 lymphadenectomy for gastric cancer: A retrospective cohort study

Brisinda¹,

Chiarello²,

Crocco³

et al. 2022

WJG

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BACKGROUND Surgery for gastric cancer is a complex procedure and lymphadenectomy is often mandatory. Postoperative mortality and morbidity after curative gastric cancer surgery is not insignificant. AIM To evaluate the factors determining mortality and morbidity in a population of patients undergoing R0 resection and D2 lymphadenectomy for gastric cancer. METHODS A retrospective analysis of clinical data and pathological characteristics (age, sex, primary site of the tumor, Lauren histotype, number of positive lymph nodes resected, number of negative lymph nodes resected, and depth of invasion as defined by the standard nomenclature) was conducted in patients with gastric cancer. For each patient we calculated the Kattan’s score. We arbitrarily divided the study population of patients into two groups based on the nomogram score (< 100 points or ≥ 100 points). Prespecified subgroups in these analyses were defined according to age (≤ 65 years or > 65 years), and number of lymph nodes retrieved (≤ 35 lymph nodes or > 35 lymph nodes). Uni- and multivariate analysis of clinical and pathological findings were performed to identify the factors affecting postoperative mortality and morbidity. RESULTS One-hundred and eighty-six patients underwent a curative R0 resection with D2 lymphadenectomy. Perioperative mortality rate was 3.8% (7 patients); a higher mortality rate was observed in patients aged > 65 years ( P = 0.002) and in N+ patients ( P = 0.04). Following univariate analysis, mortality was related to a Kattan’s score ≥ 100 points ( P = 0.04) and the presence of advanced gastric cancer ( P = 0.03). Morbidity rate was 21.0% (40 patients). Surgical complications were observed in 17 patients (9.1%). A higher incidence of morbidity was observed in patients where more than 35 lymph nodes were harvested ( P = 0.0005). CONCLUSION Mortality and morbidity rate are higher in N+ and advanced gastric cancer patients. The removal of more than 35 lymph nodes does not lead to an increase in mortality.

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“…The ERAS Society provides guidelines for many types of surgery, and all these pathways include items for a complete perioperative management of patients, including fragile ones [8,[18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Impact of the COVID‐19 Pandemic on Enhanced Recovery After Surgery (ERAS) Application and Outcomes: Analysis in the “Lazio Network” Database

Grieco

Galiffa²,

Marcellinaro³

et al. 2022

World j. surg.

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Background The aim of this study was to investigate how the COVID-19 pandemic influenced ERAS program application in colorectal surgery across hospitals in the Lazio region (central district in Italy) participating in the “Lazio Network” project. Methods A multi-institutional database was constructed. All patients included in this study underwent elective colorectal surgery for both malignant and benign disease between January 2019 and December 2020. Emergency procedures were excluded. The population was divided into 2 groups: a pre-COVID-19 group (PG) of patients operated on between February and December 2019 and a COVID-19 group (CG) of patients operated on between February and December 2020, during the first 2 waves of the pandemic in Italy. Results The groups included 622 patients in the PG and 615 in the CG treated in 8 hospitals of the network. The mean number of items applied was higher in the PG (65.6% vs. 56.6%, p < 0.001) in terms of preoperative items (64.2% vs. 50.7%, p < 0.001), intraoperative items (65.0% vs. 53.3%, p < 0.001), and postoperative items (68.8% vs. 63.2%, p < 0.001). Postoperative recovery was faster in the PG, with a shorter time to first flatus, first stool, autonomous mobilization and discharge (6.82 days vs. 7.43 days, p = 0.021). Postoperative complications, mortality and reoperations were similar among the groups. Conclusions The COVID-19 pandemic had a negative impact on the application of ERAS in the centers of the “Lazio Network” study group, with a reduction in adherence to the ERAS protocol in terms of preoperative, intraoperative and postoperative items. In addition, in the CG, the patients had worse postoperative outcomes with respect to recovery and discharge. Supplementary Information The online version contains supplementary material available at 10.1007/s00268-022-06694-8.

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Global updates in the treatment of gastric cancer: a systematic review. Part 2: perioperative management, multimodal therapies, new technologies, standardization of the surgical treatment and educational aspects

Cited by 20 publications

References 152 publications

Downregulation of LINC01857 Increases Sensitivity of Gastric Carcinoma Cells to Cisplatin

Downregulation of LINC01857 Increases Sensitivity of Gastric Carcinoma Cells to Cisplatin

Postoperative mortality and morbidity after D2 lymphadenectomy for gastric cancer: A retrospective cohort study

Impact of the COVID‐19 Pandemic on Enhanced Recovery After Surgery (ERAS) Application and Outcomes: Analysis in the “Lazio Network” Database

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