Global trends of pulmonary infections with nontuberculous mycobacteria: a systematic review

Mathiasen, Victor Dahl; Mølhave, Martin; Fløe, Andreas; Ingen, Jakko van; Schön, Prof Thomas; Lillebaek, Prof Troels; Andersen, Prof Aase Bengaard; Wejse, Christian

doi:10.1016/j.ijid.2022.10.013

Cited by 100 publications

(41 citation statements)

References 84 publications

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“…Clinically relevant infections with non-tuberculous mycobacteria (NTM) such as the Mycobacterium avium complex (MAC) and Mycobacterium abscessus (MAB) are increasing (1). Current treatment regimens are inefficient as illustrated by the treatment duration of at least 12 months for pulmonary disease with cure rates at 40-50% for MAB and 50-70% for MAC with a microbiological recurrence rate of 30% (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Towards clinical breakpoints for non-tuberculous mycobacteria – Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution

Fröberg¹,

Maurer²,

Chryssanthou³

et al. 2023

Clinical Microbiology and Infection

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Section: Introductionmentioning

confidence: 99%

Towards clinical breakpoints for non-tuberculous mycobacteria – Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution

Fröberg¹,

Maurer²,

Chryssanthou³

et al. 2023

Clinical Microbiology and Infection

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“…Notably, Mab remains one of the most difficult-to-treat pathogens among all NTM species (5,6). The prevalence of Mab in NTM-LD ranges from 5 to 40% across different locations (7). Patients with underlying comorbidities, such as COPD and CF, experience substantial deterioration in lung function, diminished quality of life, and reduced survival rates (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus

Zhang,

Limwongyut,

Moreland

et al. 2024

Sci. Transl. Med.

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Infections caused by nontuberculous mycobacteria have increased more than 50% in the past two decades and more than doubled in the elderly population. Mycobacterium abscessus (Mab), one of the most prevalent of these rapidly growing species, is intrinsically resistant to numerous antibiotics. Current standard-of-care treatments are not satisfactory, with high failure rate and notable adverse effects. We report here a potent anti-Mab compound from the flexible molecular framework afforded by conjugated oligoelectrolytes (COEs). A screen of structurally diverse, noncytotoxic COEs identified a lead compound, COE-PNH 2 , which was bactericidal against replicating, nonreplicating persisters and intracellular Mab.COE-PNH 2 had low propensity for resistance development, with a frequency of resistance below 1.25 × 10 −9 and showed no detectable resistance upon serial passaging. Mechanism of action studies were in line with COE-PNH 2 affecting the physical and functional integrity of the bacterial envelope and disrupting the mycomembrane and associated essential bioenergetic pathways. Moreover, COE-PNH 2 was well-tolerated and efficacious in a mouse model of Mab lung infection. This study highlights desirable in vitro and in vivo potency and safety index of this COE structure, which represents a promising anti-mycobacterial to tackle an unmet medical need.

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“…NTM infection can cause a variety of clinical diseases, including lung infection, skin and soft tissue infection, etc. Its treatment and prevention is a complex and challenging process [3]. Due to the increasing diversity and drug resistance of NTM strains, as well as the differences in the immune status of patients, the choice of treatment regimen should be carefully individualized according to the speci c situation [4].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of non-tuberculous mycobacterium in central China were analyzed based on the macropathogenic mNGS sequencing technology

Yang,

Liu,

Yang

et al. 2024

Preprint

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Objective: Metagenomics next generation sequencing (mNGS) was used to investigate the pathogenic factors, epidemic characteristics and clinical characteristics of non-tuberculous mycobacterium in central China. Methods：The pathological data of 320 patients with mycobacterium infection diagnosed in the Department of Pathology of Hunan People's Hospital from June 2019 to December 2023 were collected, including HE staining, acid-fast and fungal fluorescence staining, and macrogenetic pathoomics next generation sequencing (mNGS) detection to classify mycobacterium pathogens. Results：Among 320 patients with mycobacterium detection, 249 were positive for mycobacterium tuberculosis and 71 were positive for non-mycobacterium tuberculosis. Thirteen non-tuberculous mycobacterium genera were identified in the samples from central China, including M. chelonis, M. avium complex group, M. abscess, M. Gordon, M. intracellular, M. tobacco-Kansas, M. paracondontium, M. Aubris, M. margherita, M. fortuitus, M. smegmatis and M. margherita. Conclusion:Non-tuberculous mycobacterium infections gradually increased, and the clinical infection mode began to change from single strain infection to multi-strain combined complex infection. It was very difficult to distinguish non-tuberculous mycobacterium from mycobacterium tuberculosis by simple pathologic diagnosis. The application of mNGS contributed to solving this problem and improving the clinical diagnosis rate and early treatment.

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Global trends of pulmonary infections with nontuberculous mycobacteria: a systematic review

Cited by 100 publications

References 84 publications

Towards clinical breakpoints for non-tuberculous mycobacteria – Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution

Towards clinical breakpoints for non-tuberculous mycobacteria – Determination of epidemiological cut off values for the Mycobacterium avium complex and Mycobacterium abscessus using broth microdilution

An anti-mycobacterial conjugated oligoelectrolyte effective against Mycobacterium abscessus

Clinical characteristics of non-tuberculous mycobacterium in central China were analyzed based on the macropathogenic mNGS sequencing technology

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