Global Trends in Research of Antimicrobial Peptides for the Treatment of Drug-Resistant Bacteria from 1995 to 2021: A Bibliometric Analysis

Liang, Yuelong; Huang, Zhenzhen; Shen, Xuqiu; Zhang, Yiyin; Chai, Yi; Jiang, Kexin; Chen, Qihao; Zhang, Feng

doi:10.2147/idr.s411222

Cited by 3 publications

(2 citation statements)

References 50 publications

(35 reference statements)

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“…Considering the characteristics and the mechanism of action of the AMPs that commonly target the bacterial cell membrane through multiple mechanisms and pathways, the efficacy of the treatment is increased and the development of resistance becomes unlikely to occur [24,31,[86][87][88][89]. AMPs are sequences that generally have less than 100 amino acids.…”

Section: Introductionmentioning

confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach. Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides

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Section: Introductionmentioning

confidence: 99%

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Franca-Oliveira,

Hernández-Ledesma,

Martinez-Rodriguez

2024

BCHD

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“…These peptides can kill bacteria, fungi, and even cancer cells by permeabilizing the cellular membranes. Due to their activity against bacteria, AMPs have been actively tested as potential candidates in the development of antimicrobial agents for the treatment of emerging drug-resistant infections [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Effect of CM15 on Supported Lipid Bilayer Probed by Atomic Force Microscopy

Walsh,

Choi,

Sigdel

2023

Membranes

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Antimicrobial peptides are key components of the immune system. These peptides affect the membrane in various ways; some form nano-sized pores, while others only produce minor defects. Since these peptides are increasingly important in developing antimicrobial drugs, understanding the mechanism of their interactions with lipid bilayers is critical. Here, using atomic force microscopy (AFM), we investigated the effect of a synthetic hybrid peptide, CM15, on the membrane surface comprising E. coli polar lipid extract. Direct imaging of supported lipid bilayers exposed to various concentrations of the peptide revealed significant membrane remodeling. We found that CM15 interacts with supported lipid bilayers and forms membrane-spanning defects very quickly. It is found that CM15 is capable of remodeling both leaflets of the bilayer. For lower CM15 concentrations, punctate void-like defects were observed, some of which re-sealed themselves as a function of time. However, for CM15 concentrations higher than 5 µM, the defects on the bilayers became so widespread that they disrupted the membrane integrity completely. This work enhances the understanding of CM15 interactions with the bacterial lipid bilayer.

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Bibliometric Analysis of Antibacterial Drug Resistance

Netthong,

Khumsikiew,

Donsamak

et al. 2024

Frontiers in Combating Antibacterial Resistance

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As the burden of antibacterial drug resistance continues to increase, understanding the landscape of existing research is crucial for navigating future directions and strategies. This chapter presents a thorough bibliometric analysis of the literature pertaining to antibacterial drug resistance. The analysis spans the evolution, current status, and emerging trends within this critical field. Employing key bibliometric tools and techniques, this overview maps publication trends, dominant research themes, geographical distributions, and the most influential contributors to the discipline. The insights garnered provide a comprehensive understanding of where research has been concentrated, highlight gaps in current knowledge, and point toward areas of future promise. With the ever-present need for novel approaches to mitigating antibacterial drug resistance, understanding the bibliometric contours of the field offers valuable guidance for researchers, policymakers, and practitioners alike.

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Global Trends in Research of Antimicrobial Peptides for the Treatment of Drug-Resistant Bacteria from 1995 to 2021: A Bibliometric Analysis

Cited by 3 publications

References 50 publications

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Bioactive peptides as alternative treatment for Helicobacter pylori infection

Effect of CM15 on Supported Lipid Bilayer Probed by Atomic Force Microscopy

Bibliometric Analysis of Antibacterial Drug Resistance

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