Global trends in polycystic ovary syndrome research: A 10-year bibliometric analysis

Shi, Na; Ma, Huili

doi:10.3389/fendo.2022.1027945

Cited by 4 publications

(3 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Polycystic ovary syndrome is one of the most common and complex endocrine and metabolic disorders (8, 9), which is de ned as a multisystem disorder in women of reproductive age (10). The prevalence of PCOS is different based on different diagnostic criteria (11) and is reported in the range of 4-21% (12). It appears that abnormal metabolic and hormonal conditions in women with PCOS, such as high levels of androgens and estrogens and low levels of SHBG in particular, can be involved in the pathogenesis of breast cancer (13).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the relationship between breast cancer and clinical symptoms of polycystic ovarian syndrome: a case-control study

Hemati,

Amini,

Hashemi

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Despite the overlap between the clinical symptoms of polycystic ovary syndrome (PCOS) and many known risk factors for breast cancer, the relationship between PCOS and breast cancer remains unknown. Therefore, this study was conducted with the aim of determining the relationship between breast cancer and the clinical symptoms of PCOS. Method This case-control study was conducted on 285 women with breast cancer and 285 healthy women referred to three centers in Tehran in 2023. Both the case and control groups were matched in terms of age and body mass index. The data collection tool in this study was a researcher-made data registration form, that was completed in person by qualified individuals. A history of PCOS was identified according to the Rotterdam criteria. Data were analyzed using an independent t-test, a chi-square test, and a logistic regression model. Results The mean age of the participants in the case group was 43.05 ± 4.92 years and that of the control group was 42.78 ± 5.06 years. The two groups showed a statistically significant difference in terms of PCOS history (p < 0.001). After adjusting for confounding variables, the logistic regression model showed that women with PCOS had a significantly higher chance of developing breast cancer (OR:3.677, 95%CI:1.529–8.840, P = 0.004) Among PCOS symptoms, women with a history of hirsutism had a higher chance of developing breast cancer (OR:188.2, 95% CI:1.014–4.720, P = 0.046). Conclusion The findings of the present study show that polycystic ovary syndrome is associated with an increased risk of breast cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Investigation of the relationship between breast cancer and clinical symptoms of polycystic ovarian syndrome: a case-control study

Hemati,

Amini,

Hashemi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…One of the most common endocrine heterogenous disorders among women of reproductive age is polycystic ovary syndrome (PCOS), which involves the reproductive, metabolic, and endocrine systems [1]. Symptoms such as infertility, oligomenorrhea, metabolic disorders, and cutaneous manifestations are connected with PCOS.…”

Section: Introductionmentioning

confidence: 99%

Examining the Genetic Role of rs8192675 Variant in Saudi Women Diagnosed with Polycystic Ovary Syndrome

Alsobaie,

Alageel,

Ishfaq

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Polycystic ovary syndrome is a complex disorder defined by the Rotterdam criteria. Insulin resistance is a common factor for the development of type 2 diabetes mellitus among women with PCOS. The SLC2A2 gene has been identified as a T2DM gene by genome-wide association studies in the rs8192675 SNP. This study aimed to investigate the rs8192675 SNP in women diagnosed with PCOS on a molecular level and further for T2DM development in the Saudi women. In this case-control study, 100 PCOS women and 100 healthy controls were selected. Among 100 PCOS women, 28 women showed T2DM development. Genotyping for rs8192675 SNP was performed by PCR-RFLP analysis. Additionally, Sanger sequencing was performed to validate the RFLP analysis. The obtained data were used for a statistical analysis for the genotype and allele frequencies, logistic regression, and ANOVA analysis. The clinical data confirmed the positive association between FBG, FI, FSH, TT, TC, HDLc, LDLc, and family histories (p < 0.05). HWE analysis was associated in both the PCOS cases and the control individuals. Genotype and allele frequencies were associated in PCOS women and strongly associated with women with PCOS who developed T2DM (p < 0.05). No association was found in the logistic regression model or ANOVA analysis studied in women with PCOS (p > 0.05). A strong association was observed between the rs8192675 SNP and women with PCOS who developed T2DM using ANOVA analysis (p < 0.05). This study confirms that the rs8192675 SNP is associated with women with PCOS and strongly associated with women with PCOS with developed T2DM in Saudi Arabia.

show abstract

“…2 Over the years, PCOS has shown a rapidly increasing trend and is frequently associated with abdominal adiposity, infertility, obstetrical problems, and cardiovascular disease, leading to a deprived life quality. 3…”

Section: Introductionmentioning

confidence: 99%

Systematic Review and Meta-Analysis on Role of Adiponectin to Leptin Ratio in Women with Polycystic Ovarian Syndrome

Iskandar,

Widjanarko,

Suryatenggara

et al. 2023

Siriraj Med J

View full text Add to dashboard Cite

Objective: PCOS or Polycystic Ovarian Syndrome, a multifaceted disorder marked by disruptions in endocrine and metabolic processes, influences reproductive age women. The most commonly used criteria for diagnosing this condition are the Rotterdam 2003 and the National Institutes of Health Consensus 1990 guidelines. Recent studies are currently focusing on novel biomarkers, such as adiponectin and leptin to gain deeper insights on the intricate pathophysiology of PCOS. Therefore, this review aimed to consolidate the importance of the A:L (adiponectin to leptin) ratio as a potential and promising biomarker for PCOS. Materials and Methods: The method followed the PRISMA 2020 guidelines. Furthermore, MEDLINE, Proquest, and EBSCOhost databases were used to obtain eligible studies published up to February 2023. This study was registered in PROSPERO on April 2, 2023 with registration number CRD42023411754. ESHRE/ASRM or Rotterdam Guideline was used as the diagnosis criteria for women with PCOS. To examine the studies' heterogeneity, the I2 statistic and Cochran's Q test were utilized. Meanwhile, the evaluation on publication bias visually employed a funnel plot and was confirmed through Egger's test and rank correlation test. Data analysis was conducted with JASP 0.17.1, and statistical significance was characterized as a p-value below 0.05. Results: In the systematic review, a total of nine studies were incorporated, and seven studies were used in the subsequent meta-analysis. Each paper showcased a reduced A:L ratio in women with PCOS, with a standardized mean difference (SMD) among PCOS and control groups of 0.49 (CI: 0.37 - 0.61). The residual heterogeneity test yielded a p-value of 0.069, and no publication bias indication both pre and post intervention (p=0.002). Conclusion: Referring to the findings, the A:L ratio was notably lower in PCOS patients. Consequently, the A:L ratio holds promise as a novel and potential biomarker for PCOS.

show abstract

Global trends in polycystic ovary syndrome research: A 10-year bibliometric analysis

Cited by 4 publications

References 36 publications

Investigation of the relationship between breast cancer and clinical symptoms of polycystic ovarian syndrome: a case-control study

Investigation of the relationship between breast cancer and clinical symptoms of polycystic ovarian syndrome: a case-control study

Examining the Genetic Role of rs8192675 Variant in Saudi Women Diagnosed with Polycystic Ovary Syndrome

Systematic Review and Meta-Analysis on Role of Adiponectin to Leptin Ratio in Women with Polycystic Ovarian Syndrome

Contact Info

Product

Resources

About