Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis

Abstract

Nanotechnology has emerged as a promising tool in the clinic to combat several difficult-to-manage diseases, such as cancer, which is the second leading cause of death worldwide. Chemotherapeutic drugs present several limitations such as undesired side effects, low specificity, resistance, and high relapse rates. Triple negative breast cancer (TNBC) is caused by cells that lack specific receptors in their membrane, such as estrogen (ER+) and progesterone (PR+) receptors, or by cells that do not express the amplification of human epidermal growth factor receptor-2 (HER-2+). This cancer type has poor prognosis, high relapse rates, and no targeted therapies. Thus, this study aimed to investigate the trends of nanotechnology research in TNBC and compare the contribution of research from different regions, institutions, and authors. A search of the studies published between 2012 and 2017, related to nanotechnology and TNBC, with different keyword combinations, was performed in the Scopus database. The keywords found in this search were grouped into four clusters, in which “breast cancer” was the most mentioned (1,133 times) and the word “MCF-7 cell line” is one of the latest hotspots that appeared in the year 2016. A total of 1,932 articles, which were cited 26,450 times, were identified. The USA accounted for 28.36% of the articles and 27.61% of the citations; however, none of its centers appeared in the list of 10 most productive ones in terms of publications. The journals Biomaterials and International Journal of Nanomedicine had the highest number of publications. The USA and China had the highest number of articles produced and cited; however, the highest average citation per article was from Singapore. The studies focused on the research of antineoplastic agents in animal models and cell culture, and these were the most used topics in research with nanotechnology and TNBC.

Global research trends in microbiome-gut-brain axis during 2009–2018: a bibliometric and visualized study

“…Although a large number of databases are used for evaluation research at global level [45][46][47], the current study uses the Scopus database which is widely accepted among researchers for the purposes of high quality bibliometric analyses [44,[48][49][50][51][52][53]. Scopus is the world's largest abstract and citation database of peer-reviewed research literature, and is an established resource for identifying biomedical research including MEDLINE documents, and includes a higher level of detail than PubMed including the country of origin and citations per document [47,54].…”

Nanomedicine: Insights from a Bibliometrics-Based Analysis of Emerging Publishing and Research Trends

“…There are few scholarly investigations concerning the publishing trends related to the medical applications of nanotechnologies and nanosciences. Teles and collaborators [17] have focused on the potential promises of nanomedicine for the management and treatment of triple negative breast cancer (TNBC), mining the literature (Scopus database) from 2012 to 2017. Authors found that most articles concerned antineoplastic agents tested using in-vitro models, cell cultures, or animal models.…”

Mapping Research in the Obesity, Adipose Tissue, and MicroRNA Field: A Bibliometric Analysis

“…The Scopus database was selected to perform a literature search, once it is considered to be a reliable process for acquiring bibliometric indicators, such as abstracts, citations, and other data mostly used in bibliometric studies in the area of medicine [44,45]. Two investigators (JMA and RHGT) independently conducted a search in the Scopus database using the following keywords and Boolean operators: (microRNA OR miRNA OR miRNAs OR miR-1 OR miR-2 OR miR-3 OR miR-4 OR miR-5 OR miR-6 OR miR-7 OR miR-8 OR miR-9) and (obesity AND "adipose tissue" ORadipogenesis.…”