Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF
Eike C. Struck,
Tatiana Belova,
Ping-Han Hsieh
et al.
Abstract:The vascular endothelium acts as a dynamic interface between blood and tissue. TNF-α, a major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the overall response dynamics of which have not been fully elucidated. In the present study, we conducted an extended time-course analysis of the human EC response to TNF, from 30 min to 72 h. We identified regulated genes and used weighted gene network correlation analysis to decipher coexpression profiles, uncovering two distinct tempo… Show more
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