Global Stability Analysis of the Role of Antiretroviral Therapy (ART) Abuse in HIV/AIDS Treatment Dynamics

Abstract

Devastatingly, in spite of the long standing research works on HIV/AIDS infection and treatment dynamics, reviews of existing models clearly shown that the behavioral attitude to treatment consistency by those screened to become aware and those receiving treatment have not been given the desired attention. Moreso, the inconsistency following avoidable treatment truncation and later resumption of treatment by these classes of infectives, which could lead to colossal drug abuse is also not accorded the much expected consideration. Therefore, in this present study, we sought and formulated a nonlinear 6-Dimensional deterministic mathematical HIV/AIDS dynamic model that accounted for the global stability analysis of the role of antiretroviral therapy abuse for the treatment of HIV/AIDS epidemic. The model is structured upon dynamical interactions between 6-subpopulations and HI-virus under bilinear control functions with constant screening of the susceptible. It is assumed that the rate of resumption of ART upon truncation is less than initial ART truncation following the incorporation of HIV aware infectives not ready to receive ART treatment and HIV aware infectives with truncated treatment protocol The system mathematical well-posedness was investigated and model reproduction number determined for both off-treatment (with value 0.343 ) and for onset-treatment (with value 0.271). We considered the model for off-treatment and thereafter by incorporating LaSalle's invariant principle into classical Lyapunov function method, we presented an approach for the global stability analysis of the role of ART abuse in HIV/AIDS treatment. Furthermore, the analysis and results of this paper presented a dynamic methodological application of bilinear control functions and an impeccable understanding of the fundamental mechanism in HIV/AIDS treatment in the presence of ART abuse. Using in-built Runge-Kutta of order of precision 4 in a Mathcad surface, numerical validity of model is conducted to investigate the study theoretical and analytical predictions. Results shows that application of onset-treatment functions with trend of ART abuse yield tremendous reduction in HIV/AIDS infection epidemic following the recovery rate of the susceptible population with value increasing from 0.5 cells/mm 3 to 1.203 cells/mm 3 within the first 3 months and attained stability of 0.62 cells/mm 3 through the time interval of 20-30 months.