Global spread of New Delhi metallo-β-lactamase 1

Göttig, Stephan; Pfeifer, Yvonne; Wichelhaus, Thomas A.; Zacharowski, Kai; Bingold, Tobias M.; Averhoff, Beate; Brandt, Christian; Kempf, Volkhard A. J.

doi:10.1016/s1473-3099(10)70275-9

Cited by 54 publications

(39 citation statements)

References 2 publications

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“…Many NDM-1 cases had co-morbidities and/or had undergone an invasive care procedure [1,2,[19][20][21][22][23][24][25][26]. The clinical spectrum and severity of illness appears similar to that expected for Enterobacteriaceae infections in this patient population.…”

Section: Epidemic Risk Assessmentmentioning

confidence: 58%

“…Cases were also reported from Australia [18], Canada [19], Singapore [21] and the US [10]. Infections with NDM-1-producing Acinetobacter baumannii were reported from Germany, India and the UK [2,17,22]. Investigations showed that the NDM-1 enzyme was frequently detected among clinical Enterobacteriaceae isolates in Chennai, Haryana, Mumbai and other Indian cities [2,10].…”

Section: Resultsmentioning

confidence: 99%

“…Carbapenem resistance mediated by NDM-1 enzyme has been detected by clinical laboratories with routine phenotypic testing methods, including disc diffusion testing [1,2,10,11,[18][19][20][21][22][23][24][25][26]. Any Enterobacteriaceae isolate that exhibits a minimum inhibitory concentration (MIC) above the epidemiological cut-off or with clinical resistance to ertapenem, imipenem or meropenem should trigger further testing [12,27] Carbapenemase activity can be screened by using the modified Hodge test [2,[10][11][12] and, as with other metallo-beta-lactamases, synergy can be detected by EDTA-imipenem disc or Etest [1,2,10-12,].…”

Section: Laboratory Detection and Identificationmentioning

confidence: 99%

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New Delhi metallo-beta-lactamase 1–producing Enterobacteriaceae: emergence and response in Europe

et al. 2010

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Acquired carbapenemases confer extensive antibiotic resistance to Enterobacteriaceae and represent a public health threat. A novel acquired carbapenemase, New Delhi metallo-beta-lactamase 1 (NDM-1), has recently been described in the United Kingdom and Sweden, mostly in patients who had received care on the Indian subcontinent. We conducted a survey among 29 European countries (the European Union Member States, Iceland and Norway) to gather information on the spread of NDM-1-producing Enterobacteriaceae in Europe, on public health responses and on available national guidance on detection, surveillance and control. A total of 77 cases were reported from 13 countries from 2008 to 2010. Klebsiella pneumoniae was the most frequently reported species with 54%. Among 55 cases with recorded travel history, 31 had previously travelled or been admitted to a hospital in India or Pakistan and five had been hospitalised in the Balkan region. Possible nosocomial acquisition accounted for 13 of 77 cases. National guidance on NDM-1 detection was available in 14 countries and on NDM-1 control in 11 countries. In conclusion, NDM-1 is spreading across Europe, where it is frequently linked to a history of healthcare abroad, but also to emerging nosocomial transmission. National guidance in response to the threat of carbapenemase-producing Enterobacteriaceae is available in approximately half of the surveyed European countries. Surveillance of carbapenemase- producing Enterobacteriaceae must be enhanced in Europe and effective control measures identified and implemented.

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Section: Epidemic Risk Assessmentmentioning

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Laboratory Detection and Identificationmentioning

confidence: 99%

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New Delhi metallo-beta-lactamase 1–producing Enterobacteriaceae: emergence and response in Europe

et al. 2010

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“…The most recent MBLs identified in A. baumannii are the emerging NDM enzymes. The bla NDM genes have mostly been reported in Enterobacteriaceae, but there have been reports of NDM-1 in A. baumannii from India (28) and Germany (29). These isolates were resistant to high levels of all b-lactams, including carbapenems.…”

Section: Acquired Carbapenem-hydrolyzing B-lactamasesmentioning

confidence: 99%

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

2011

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SummaryAntibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic b-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mechanisms of resistance have been identified in A. baumannii. The very high genetic plasticity of A. baumannii allows an accumulation of resistance determinants that give rise to multidrug resistance at an alarming rate. The role of novel genetic elements, such as resistance islands, in concentrating antibiotic resistance genes in A. baumannii requires detailed investigation in the near future.

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“…The bla NDM-1 gene, identified initially in Klebsiella pneumoniae and Escherichia coli strains mostly from India and Pakistan, was recently identified extensively in other enterobacterial species worldwide (18,21). Besides spread of the NDM gene in Enterobacteriaceae, NDM producers in A. baumannii are increasingly being identified worldwide (9)(10)(11).…”

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confidence: 99%

Phenotypic, Biochemical, and Molecular Techniques for Detection of Metallo-β-Lactamase NDM in Acinetobacter baumannii

2012

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Seven NDM-positive Acinetobacter baumannii isolates of worldwide origin were studied to evaluate the best technique for their identification. Detection of carbapenemase producers based on the measurement of carbapenemase activity by UV spectrophotometry (as for A. baumannii strains producing other types of carbapenemase), or by the modified Hodge test, failed. Inhibition activity using EDTA was a sensitive technique but lacked specificity compared to molecular techniques, which remain the gold standard.

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Global spread of New Delhi metallo-β-lactamase 1

Cited by 54 publications

References 2 publications

New Delhi metallo-beta-lactamase 1–producing Enterobacteriaceae: emergence and response in Europe

New Delhi metallo-beta-lactamase 1–producing Enterobacteriaceae: emergence and response in Europe

Genetic basis of antibiotic resistance in pathogenic Acinetobacter species

Phenotypic, Biochemical, and Molecular Techniques for Detection of Metallo-β-Lactamase NDM in Acinetobacter baumannii

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