Global Spread of Drug-Resistant
 Acinetobacter Baumannii
 : Molecular Epidemiology And Management Of Antimicrobial Resistance

Durante‐Mangoni, Emanuele; Zarrilli, Raffaele

doi:10.2217/fmb.11.23

Cited by 141 publications

(104 citation statements)

References 163 publications

(327 reference statements)

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“…In this study, most of the isolates showed carbapenem associated multidrug resistance, which was similar as other areas of the United States and worldwide [9] [11] [30], and more sadly some of them conferred intermediate levels of polymyxin resistance. Outbreaks of polymyxin associated carbapenem resistant A. baumannii should alert in this area.…”

Section: Discussionsupporting

confidence: 78%

“…Outbreaks of carbapenem associated multidrug resistant A. baumannii may be the most problematic issue to treat the infected patients since the only viable therapeutic option for this infection is polymyxins [9], but polymyxins cause neuro-and nephro-toxicity [27] and polymyxin selection pressure can readily develop polymyxin resistant A. baumannii [28] [29]. In this study, most of the isolates showed carbapenem associated multidrug resistance, which was similar as other areas of the United States and worldwide [9] [11] [30], and more sadly some of them conferred intermediate levels of polymyxin resistance.…”

Section: Discussionmentioning

confidence: 99%

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Dissemination and Genetic Structure of Carbapenemase Encoding Genes (blaOXA-23 and blaOXA-24) in Acinetobacter baumannii from Southern Texas

Azam¹,

Talukder²,

Robinson³

et al. 2015

AiM

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Acinetobacter baumannii is one of the most important human pathogens causing a variety of nosocomial infections. Carbapenem antibiotics have been primarily used to treat the A. baumannii infections. However, carbapenem resistant A. baumannii producing carbapenemases causes serious treatment problems worldwide. Outbreaks of carbapenem resistant isolates have reported in some area of the United States, but their dissemination and genetic structure of the carbapenemase encoding genes are currently little known. To understand outbreaks, dissemination, and genetic structure of the carbapenemase encoding genes in Southern Texas, 32 clinical isolates collected from Austin and Houston, TX were characterized. Twenty-eight of 32 isolates were resistant to all tested β-lactam antibiotics including carbapenem (imipenem and meropenem). Three of them carried blaOXA-23 as a part of Tn2008 integrated into a known plasmid (pACICU2) and all others carried blaOXA-24 flanked by XerC/XerD-like recombinase binding sites that were adjoined by DNA sequences originated from multiple plasmids. Genotype analysis revealed that the 25 isolates carrying blaOXA-24 were all identical genotypes same as a representative isolate carrying blaOXA-24 from Chicago, IL but the 3 isolates carrying blaOXA-23 was a distinct genotype as compared with isolates carrying blaOXA-23 from Chicago, IL and Washington, D.C. Each of the blaOXA-23 and blaOXA-24 was transferred to carbapenem susceptible A. baumannii and E. coli with similar minimal inhibitory concentration (MIC) of carbapenem as that of their parental isolates but significantly lower levels of MIC in E. coli. Overall results suggest that a unique strain carrying blaOXA-23 and a similar strain carrying blaOXA-24 as seen in other geographic areas are currently disseminated in Southern Texas.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (blaOXA-23 and blaOXA-24) in Acinetobacter baumannii from Southern Texas

Azam¹,

Talukder²,

Robinson³

et al. 2015

AiM

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“…NIHR Journals Library www.journalslibrary.nihr.ac.uk the changing epidemiology of HCAIs, 589,[607][608][609][610] exemplified by the rise of MRSA and extended-spectrum beta-lactamase (ESBL)-producing strains of Escherichia coli and Klebsiella pneumonia. 609,[611][612][613][614][615][616][617][618][619] In the NHS, following major outbreaks of hospital-acquired (nosocomial) infection, 620 national targets for the reduction of MRSA bacteremias (blood infections) and C. difficile (gastrointestinal) infection are supported by enhanced mandatory surveillance.…”

Section: Reducing Health-care-associated Infectionmentioning

confidence: 99%

A realist analysis of hospital patient safety in Wales: applied learning for alternative contexts from a multisite case study

Herepath

Kitchener

Waring

2015

Health Serv Deliv Res

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BackgroundHospital patient safety is a major social problem. In the UK, policy responses focus on the introduction of improvement programmes that seek to implement evidence-based clinical practices using the Model for Improvement, Plan-Do-Study-Act cycle. Empirical evidence that the outcomes of such programmes vary across hospitals demonstrates that the context of their implementation matters. However, the relationships between features of context and the implementation of safety programmes are both undertheorised and poorly understood in empirical terms.ObjectivesThis study is designed to address gaps in conceptual, methodological and empirical knowledge about the influence of context on the local implementation of patient safety programmes.DesignWe used concepts from critical realism and institutional analysis to conduct a qualitative comparative-intensive case study involving 21 hospitals across all seven Welsh health boards. We focused on the local implementation of three focal interventions from the 1000 Lives+patient safety programme: Improving Leadership for Quality Improvement, Reducing Surgical Complications and Reducing Health-care Associated Infection. Our main sources of data were 160 semistructured interviews, observation and 1700 health policy and organisational documents. These data were analysed using the realist approaches of abstraction, abduction and retroduction.SettingWelsh Government and NHS Wales.ParticipantsInterviews were conducted with 160 participants including government policy leads, health managers and professionals, partner agencies with strategic oversight of patient safety, advocacy groups and academics with expertise in patient safety.Main outcome measuresIdentification of the contextual factors pertinent to the local implementation of the 1000 Lives+patient safety programme in Welsh NHS hospitals.ResultsAn innovative conceptual framework harnessing realist social theory and institutional theory was produced to address challenges identified within previous applications of realist inquiry in patient safety research. This involved the development and use of an explanatory intervention–context–mechanism–agency–outcome (I-CMAO) configuration to illustrate the processes behind implementation of a change programme. Our findings, illustrated by multiple nested I-CMAO configurations, show how local implementation of patient safety interventions are impacted and modified by particular aspects of context: specifically, isomorphism, by which an intervention becomes adapted to the environment in which it is implemented; institutional logics, the beliefs and values underpinning the intervention and its source, and their perceived legitimacy among different groups of health-care professionals; and the relational structure and power dynamics of the functional group, that is, those tasked with implementing the initiative. This dynamic interplay shapes and guides actions leading to the normalisation or the rejection of the patient safety programme.ConclusionsHeightened awareness of the influence of context on the local implementation of patient safety programmes is required to inform the design of such interventions and to ensure their effective implementation and operationalisation in the day-to-day practice of health-care teams. Future work is required to elaborate our conceptual model and findings in similar settings where different interventions are introduced, and in different settings where similar innovations are implemented.FundingThe National Institute for Health Research Health Services and Delivery Research programme.

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“…In order to determine the outcome of infections more attention should be paid to the interaction between A. baumannii and the host epithelial cells (4,10). The adherence potential of A. baumannii to human bronchial epithelial cells and its resistance to major antimicrobial agents explain its survival in the medical environment and the human host (11). A few molecular factors are required for A. baumannii virulence in humans.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii

Payam

Rasooli

Owlia

et al. 2018

Arch Clin Infect Dis

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Background: Adhesion to host cells is an important and critical feature of Acinetobacter baumannii pathogenesis. OmpA, ABAYE1319-CsuA/b, and ABAYE2132 are highly prevalent and conserved fimbrial proteins; ABAYE1859 and ABAYE0304 fimbrial antigens are the factors described as novel vaccine candidates against multidrug-resistant (MDR) A. baumannii. Methods: The current study aimed at investigating the significance of A. baumannii fimbrial and outer membrane proteins A (OmpA) in adherence to human epithelial cells. Antibiotic resistance was determined by the broth microdilution method. Phenotypic identification of isolates producing ESBL (extended-spectrum beta-lactamase) was conducted using double-disc synergy test (DDST). The virulence factors were detected by the polymerase chain reaction (PCR) in 100 non duplicate clinical isolates of A. baumannii; 18 clinical isolates were selected for adhesion assay based on antibiotic resistance and PCR results. Results: The current study results showed that ABAYE2132, ABAYE0304, and ABAYE1319-CsuA/B had significant correlation with cell

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Global Spread of Drug-Resistant Acinetobacter Baumannii : Molecular Epidemiology And Management Of Antimicrobial Resistance

Cited by 141 publications

References 163 publications

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (bla<sub>OXA-23</sub> and bla<sub>OXA-24</sub>) in <i>Acinetobacter baumannii</i> from Southern Texas

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (bla<sub>OXA-23</sub> and bla<sub>OXA-24</sub>) in <i>Acinetobacter baumannii</i> from Southern Texas

A realist analysis of hospital patient safety in Wales: applied learning for alternative contexts from a multisite case study

Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii

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Global Spread of Drug-Resistant Acinetobacter Baumannii : Molecular Epidemiology And Management Of Antimicrobial Resistance

Cited by 141 publications

References 163 publications

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (bla&lt;sub&gt;OXA-23&lt;/sub&gt; and bla&lt;sub&gt;OXA-24&lt;/sub&gt;) in &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; from Southern Texas

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (bla&lt;sub&gt;OXA-23&lt;/sub&gt; and bla&lt;sub&gt;OXA-24&lt;/sub&gt;) in &lt;i&gt;Acinetobacter baumannii&lt;/i&gt; from Southern Texas

A realist analysis of hospital patient safety in Wales: applied learning for alternative contexts from a multisite case study

Correlation of Virulence Factors and Cell Adhesion of Clinical Isolates of Acinetobacter baumannii

Contact Info

Product

Resources

About

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (bla<sub>OXA-23</sub> and bla<sub>OXA-24</sub>) in <i>Acinetobacter baumannii</i> from Southern Texas

Dissemination and Genetic Structure of Carbapenemase Encoding Genes (bla<sub>OXA-23</sub> and bla<sub>OXA-24</sub>) in <i>Acinetobacter baumannii</i> from Southern Texas